Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy
Background: The covid-19 pandemic sparked a debate about the safety of vaccines during pregnancy. However, pregnant women were excluded from the Pfizer-BioNTech vaccine phase 3 trials. As two years have passed since the first Covid-19 vaccine and more studies have been conducted, we want to evaluate...
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ftdoajarticles:oai:doaj.org/article:3a28fcf60ffc4decaf69542c8f7bdd08 2024-01-14T10:05:06+01:00 Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy Diana Ramasauskaite Dominyka Grinciute 2023-11-01T00:00:00Z https://doi.org/10.1016/j.tmaid.2023.102667 https://doaj.org/article/3a28fcf60ffc4decaf69542c8f7bdd08 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1477893923001278 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2023.102667 https://doaj.org/article/3a28fcf60ffc4decaf69542c8f7bdd08 Travel Medicine and Infectious Disease, Vol 56, Iss , Pp 102667- (2023) Adverse effects Maternal immune activation mRNA vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1016/j.tmaid.2023.102667 2023-12-17T01:50:15Z Background: The covid-19 pandemic sparked a debate about the safety of vaccines during pregnancy. However, pregnant women were excluded from the Pfizer-BioNTech vaccine phase 3 trials. As two years have passed since the first Covid-19 vaccine and more studies have been conducted, we want to evaluate the scientific literature to determine any actual risks in taking the vaccine during pregnancy. Methods: We conducted literature research using PubMed and Google Scholar databases from January to April 2023. As the review considers short- and long-term adverse effects it was divided into two parts. The first part was conducted as a systematic review. The second concerning long-term negative effects due to lack of research is a literature review. The inclusion criteria for the systematic review part were singleton pregnancies, women vaccinated during pregnancy, and studies from 2020 and later. The most common short-term pregnancy adverse effects were included in the search: preterm delivery, small gestation age, intrauterine death, congenital defects, stillborn, fetal growth retardation, spontaneous abortion. Maternal immune activation was the primary concern for the long-term adverse effects and whether vaccination could cause it. The search terms included maternal immune activation, fetal neurodevelopment, neuropsychiatric disorders and the studies used were from 2019. Results: Most studies showed no significant difference in short-term adverse effects between vaccinated and non-vaccinated women and their fetuses. However, the literature is insufficient to evaluate possible long-term adverse effects. Conclusion: Available evidence supports the safety of administering SARS-CoV-2 vaccines to pregnant women, but further systematic reviews and meta-analyses are essential. Maternal immune activation caused by vaccination may impact a child's neurodevelopment and should be a concern for future studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Travel Medicine and Infectious Disease 56 102667 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Adverse effects Maternal immune activation mRNA vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Adverse effects Maternal immune activation mRNA vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Diana Ramasauskaite Dominyka Grinciute Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy |
topic_facet |
Adverse effects Maternal immune activation mRNA vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Background: The covid-19 pandemic sparked a debate about the safety of vaccines during pregnancy. However, pregnant women were excluded from the Pfizer-BioNTech vaccine phase 3 trials. As two years have passed since the first Covid-19 vaccine and more studies have been conducted, we want to evaluate the scientific literature to determine any actual risks in taking the vaccine during pregnancy. Methods: We conducted literature research using PubMed and Google Scholar databases from January to April 2023. As the review considers short- and long-term adverse effects it was divided into two parts. The first part was conducted as a systematic review. The second concerning long-term negative effects due to lack of research is a literature review. The inclusion criteria for the systematic review part were singleton pregnancies, women vaccinated during pregnancy, and studies from 2020 and later. The most common short-term pregnancy adverse effects were included in the search: preterm delivery, small gestation age, intrauterine death, congenital defects, stillborn, fetal growth retardation, spontaneous abortion. Maternal immune activation was the primary concern for the long-term adverse effects and whether vaccination could cause it. The search terms included maternal immune activation, fetal neurodevelopment, neuropsychiatric disorders and the studies used were from 2019. Results: Most studies showed no significant difference in short-term adverse effects between vaccinated and non-vaccinated women and their fetuses. However, the literature is insufficient to evaluate possible long-term adverse effects. Conclusion: Available evidence supports the safety of administering SARS-CoV-2 vaccines to pregnant women, but further systematic reviews and meta-analyses are essential. Maternal immune activation caused by vaccination may impact a child's neurodevelopment and should be a concern for future studies. |
format |
Article in Journal/Newspaper |
author |
Diana Ramasauskaite Dominyka Grinciute |
author_facet |
Diana Ramasauskaite Dominyka Grinciute |
author_sort |
Diana Ramasauskaite |
title |
Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy |
title_short |
Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy |
title_full |
Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy |
title_fullStr |
Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy |
title_full_unstemmed |
Review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy |
title_sort |
review of short-term and long-term adverse effects of covid-19 vaccination during pregnancy |
publisher |
Elsevier |
publishDate |
2023 |
url |
https://doi.org/10.1016/j.tmaid.2023.102667 https://doaj.org/article/3a28fcf60ffc4decaf69542c8f7bdd08 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Travel Medicine and Infectious Disease, Vol 56, Iss , Pp 102667- (2023) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1477893923001278 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2023.102667 https://doaj.org/article/3a28fcf60ffc4decaf69542c8f7bdd08 |
op_doi |
https://doi.org/10.1016/j.tmaid.2023.102667 |
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Travel Medicine and Infectious Disease |
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56 |
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102667 |
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