Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study
Pathogenic variants (PVs) in BRCA1 and BRCA2 increase the lifetime risks of breast and ovarian cancer. Guidelines recommend breast screening (magnetic resonance imaging (MRI) and mammogram) or risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO). We sought to (1) characterize the populati...
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2023
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ftdoajarticles:oai:doaj.org/article:39b94b811966404cb28bad4c94a392e5 2023-11-12T04:21:21+01:00 Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study Aimee Roebothan Kerri N. Smith Melanie Seal Holly Etchegary Lesa Dawson 2023-10-01T00:00:00Z https://doi.org/10.3390/curroncol30100678 https://doaj.org/article/39b94b811966404cb28bad4c94a392e5 EN eng MDPI AG https://www.mdpi.com/1718-7729/30/10/678 https://doaj.org/toc/1198-0052 https://doaj.org/toc/1718-7729 doi:10.3390/curroncol30100678 1718-7729 1198-0052 https://doaj.org/article/39b94b811966404cb28bad4c94a392e5 Current Oncology, Vol 30, Iss 678, Pp 9367-9381 (2023) BRCA breast cancer ovarian cancer screening prevention health policy genetics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2023 ftdoajarticles https://doi.org/10.3390/curroncol30100678 2023-10-29T00:36:45Z Pathogenic variants (PVs) in BRCA1 and BRCA2 increase the lifetime risks of breast and ovarian cancer. Guidelines recommend breast screening (magnetic resonance imaging (MRI) and mammogram) or risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO). We sought to (1) characterize the population of BRCA1/2 PV carriers in Newfoundland and Labrador (NL), (2) evaluate risk-reducing interventions, and (3) identify factors influencing screening and prevention adherence. We conducted a retrospective study from a population-based provincial cohort of BRCA1/2 PV carriers. The eligibility criteria for risk-reducing interventions were defined for each case and patients were categorized based on their level of adherence with recommendations. Chi-squared and regression analyses were used to determine which factors influenced uptake and level of adherence. A total of 276 BRCA1/2 PV carriers were identified; 156 living NL biological females composed the study population. Unaffected females were younger at testing than those with a cancer diagnosis (44.4 years versus 51.7 years; p = 0.002). Categorized by eligibility, 61.0%, 61.6%, 39.0%, and 75.7% of patients underwent MRI, mammogram, RRM, and RRSO, respectively. Individuals with breast cancer were more likely to have RRM (64.7% versus 35.3%; p < 0.001), and those who attended a specialty hereditary cancer clinic were more likely to be adherent to recommendations (73.2% versus 13.4%; p < 0.001) and to undergo RRSO (84.1% versus 15.9%; p < 0.001). Nearly 40% of the female BRCA1/2 PV carriers were not receiving breast surveillance according to evidence-based recommendations. Cancer risk reduction and uptake of breast imaging and prophylactic surgeries are significantly higher in patients who receive dedicated specialty care. Organized hereditary cancer prevention programs will be a valuable component of Canadian healthcare systems and have the potential to reduce the burden of disease countrywide. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Current Oncology 30 10 9367 9381 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
BRCA breast cancer ovarian cancer screening prevention health policy genetics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
BRCA breast cancer ovarian cancer screening prevention health policy genetics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Aimee Roebothan Kerri N. Smith Melanie Seal Holly Etchegary Lesa Dawson Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study |
topic_facet |
BRCA breast cancer ovarian cancer screening prevention health policy genetics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Pathogenic variants (PVs) in BRCA1 and BRCA2 increase the lifetime risks of breast and ovarian cancer. Guidelines recommend breast screening (magnetic resonance imaging (MRI) and mammogram) or risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO). We sought to (1) characterize the population of BRCA1/2 PV carriers in Newfoundland and Labrador (NL), (2) evaluate risk-reducing interventions, and (3) identify factors influencing screening and prevention adherence. We conducted a retrospective study from a population-based provincial cohort of BRCA1/2 PV carriers. The eligibility criteria for risk-reducing interventions were defined for each case and patients were categorized based on their level of adherence with recommendations. Chi-squared and regression analyses were used to determine which factors influenced uptake and level of adherence. A total of 276 BRCA1/2 PV carriers were identified; 156 living NL biological females composed the study population. Unaffected females were younger at testing than those with a cancer diagnosis (44.4 years versus 51.7 years; p = 0.002). Categorized by eligibility, 61.0%, 61.6%, 39.0%, and 75.7% of patients underwent MRI, mammogram, RRM, and RRSO, respectively. Individuals with breast cancer were more likely to have RRM (64.7% versus 35.3%; p < 0.001), and those who attended a specialty hereditary cancer clinic were more likely to be adherent to recommendations (73.2% versus 13.4%; p < 0.001) and to undergo RRSO (84.1% versus 15.9%; p < 0.001). Nearly 40% of the female BRCA1/2 PV carriers were not receiving breast surveillance according to evidence-based recommendations. Cancer risk reduction and uptake of breast imaging and prophylactic surgeries are significantly higher in patients who receive dedicated specialty care. Organized hereditary cancer prevention programs will be a valuable component of Canadian healthcare systems and have the potential to reduce the burden of disease countrywide. |
format |
Article in Journal/Newspaper |
author |
Aimee Roebothan Kerri N. Smith Melanie Seal Holly Etchegary Lesa Dawson |
author_facet |
Aimee Roebothan Kerri N. Smith Melanie Seal Holly Etchegary Lesa Dawson |
author_sort |
Aimee Roebothan |
title |
Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study |
title_short |
Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study |
title_full |
Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study |
title_fullStr |
Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study |
title_full_unstemmed |
Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study |
title_sort |
specialty care and counselling about hereditary cancer risk improves adherence to cancer screening and prevention in newfoundland and labrador patients with brca1/2 pathogenic variants: a population-based retrospective cohort study |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/curroncol30100678 https://doaj.org/article/39b94b811966404cb28bad4c94a392e5 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Current Oncology, Vol 30, Iss 678, Pp 9367-9381 (2023) |
op_relation |
https://www.mdpi.com/1718-7729/30/10/678 https://doaj.org/toc/1198-0052 https://doaj.org/toc/1718-7729 doi:10.3390/curroncol30100678 1718-7729 1198-0052 https://doaj.org/article/39b94b811966404cb28bad4c94a392e5 |
op_doi |
https://doi.org/10.3390/curroncol30100678 |
container_title |
Current Oncology |
container_volume |
30 |
container_issue |
10 |
container_start_page |
9367 |
op_container_end_page |
9381 |
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1782336806072614912 |