Oxygen-linked S-nitrosation in fish myoglobins: a cysteine-specific tertiary allosteric effect.

• Published in: PLoS ONE
• Main Authors: Signe Helbo, Andrew J Gow, Amna Jamil, Barry D Howes, Giulietta Smulevich, Angela Fago
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2014
• Subjects: Medicine; R; Science; Q; Kon; Atlantic salmon
• Online Access: https://doi.org/10.1371/journal.pone.0097012; https://doaj.org/article/398f284baa7441f7abe28ab53dfd91fc

The discovery that cysteine (Cys) S-nitrosation of trout myoglobin (Mb) increases heme O2 affinity has revealed a novel allosteric effect that may promote hypoxia-induced nitric oxide (NO) delivery in the trout heart and improve myocardial efficiency. To better understand this allosteric effect, we...