Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial.
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative abundance of Ae. aegyp...
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ftdoajarticles:oai:doaj.org/article:38790fdee59a4519b6f58dcc2f5a4e3e 2023-05-15T15:11:52+02:00 Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial. Warsito Tantowijoyo Stephanie K Tanamas Indah Nurhayati Sigit Setyawan Nida Budiwati Iva Fitriana Inggrid Ernesia Dwi Satria Wardana Endah Supriyati Eggi Arguni Yeti Meitika Equatori Prabowo Bekti Andari Benjamin R Green Lauren Hodgson Edwige Rancès Peter A Ryan Scott L O'Neill Katherine L Anders M Ridwan Ansari Citra Indriani Riris Andono Ahmad Adi Utarini Cameron P Simmons 2022-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010284 https://doaj.org/article/38790fdee59a4519b6f58dcc2f5a4e3e EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010284 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010284 https://doaj.org/article/38790fdee59a4519b6f58dcc2f5a4e3e PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010284 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010284 2022-12-30T23:06:15Z The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative abundance of Ae. aegypti and Ae. albopictus before, during and after wMel-introgression. Between March 2015 and March 2020, 60,084 BG trap collections yielded 478,254 Ae. aegypti and 17,623 Ae. albopictus. Between treatment arms there was no measurable difference in Ae. aegypti relative abundance before or after wMel-deployments, with a count ratio of 0.96 (95% CI 0.76, 1.21) and 1.00 (95% CI 0.85, 1.17) respectively. More Ae. aegypti were caught per trap per week in the wMel-intervention arm compared to the control arm during wMel deployments (count ratio 1.23 (95% CI 1.03, 1.46)). Between treatment arms there was no measurable difference in the Ae. albopictus population size before, during or after wMel-deployment (overall count ratio 1.10 (95% CI 0.89, 1.35)). We also compared insecticide resistance phenotypes of Ae. aegypti in the first and second years after wMel-deployments. Ae. aegypti field populations from wMel-treated and untreated arms were similarly resistant to malathion (0.8%), permethrin (1.25%) and cyfluthrin (0.15%) in year 1 and year 2 of the trial. In summary, we found no between-arm differences in the relative abundance of Ae. aegypti or Ae. albopictus prior to or after wMel introgression, and no between-arm difference in Ae. aegypti insecticide resistance phenotypes. These data suggest neither Aedes abundance, nor insecticide resistance, confounded the epidemiological outcomes of the AWED trial. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 4 e0010284 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Warsito Tantowijoyo Stephanie K Tanamas Indah Nurhayati Sigit Setyawan Nida Budiwati Iva Fitriana Inggrid Ernesia Dwi Satria Wardana Endah Supriyati Eggi Arguni Yeti Meitika Equatori Prabowo Bekti Andari Benjamin R Green Lauren Hodgson Edwige Rancès Peter A Ryan Scott L O'Neill Katherine L Anders M Ridwan Ansari Citra Indriani Riris Andono Ahmad Adi Utarini Cameron P Simmons Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative abundance of Ae. aegypti and Ae. albopictus before, during and after wMel-introgression. Between March 2015 and March 2020, 60,084 BG trap collections yielded 478,254 Ae. aegypti and 17,623 Ae. albopictus. Between treatment arms there was no measurable difference in Ae. aegypti relative abundance before or after wMel-deployments, with a count ratio of 0.96 (95% CI 0.76, 1.21) and 1.00 (95% CI 0.85, 1.17) respectively. More Ae. aegypti were caught per trap per week in the wMel-intervention arm compared to the control arm during wMel deployments (count ratio 1.23 (95% CI 1.03, 1.46)). Between treatment arms there was no measurable difference in the Ae. albopictus population size before, during or after wMel-deployment (overall count ratio 1.10 (95% CI 0.89, 1.35)). We also compared insecticide resistance phenotypes of Ae. aegypti in the first and second years after wMel-deployments. Ae. aegypti field populations from wMel-treated and untreated arms were similarly resistant to malathion (0.8%), permethrin (1.25%) and cyfluthrin (0.15%) in year 1 and year 2 of the trial. In summary, we found no between-arm differences in the relative abundance of Ae. aegypti or Ae. albopictus prior to or after wMel introgression, and no between-arm difference in Ae. aegypti insecticide resistance phenotypes. These data suggest neither Aedes abundance, nor insecticide resistance, confounded the epidemiological outcomes of the AWED trial. |
format |
Article in Journal/Newspaper |
author |
Warsito Tantowijoyo Stephanie K Tanamas Indah Nurhayati Sigit Setyawan Nida Budiwati Iva Fitriana Inggrid Ernesia Dwi Satria Wardana Endah Supriyati Eggi Arguni Yeti Meitika Equatori Prabowo Bekti Andari Benjamin R Green Lauren Hodgson Edwige Rancès Peter A Ryan Scott L O'Neill Katherine L Anders M Ridwan Ansari Citra Indriani Riris Andono Ahmad Adi Utarini Cameron P Simmons |
author_facet |
Warsito Tantowijoyo Stephanie K Tanamas Indah Nurhayati Sigit Setyawan Nida Budiwati Iva Fitriana Inggrid Ernesia Dwi Satria Wardana Endah Supriyati Eggi Arguni Yeti Meitika Equatori Prabowo Bekti Andari Benjamin R Green Lauren Hodgson Edwige Rancès Peter A Ryan Scott L O'Neill Katherine L Anders M Ridwan Ansari Citra Indriani Riris Andono Ahmad Adi Utarini Cameron P Simmons |
author_sort |
Warsito Tantowijoyo |
title |
Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial. |
title_short |
Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial. |
title_full |
Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial. |
title_fullStr |
Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial. |
title_full_unstemmed |
Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial. |
title_sort |
aedes aegypti abundance and insecticide resistance profiles in the applying wolbachia to eliminate dengue trial. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010284 https://doaj.org/article/38790fdee59a4519b6f58dcc2f5a4e3e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010284 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010284 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010284 https://doaj.org/article/38790fdee59a4519b6f58dcc2f5a4e3e |
op_doi |
https://doi.org/10.1371/journal.pntd.0010284 |
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PLOS Neglected Tropical Diseases |
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16 |
container_issue |
4 |
container_start_page |
e0010284 |
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