Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects
Eurycoma longifolia Jack (E. longifolia) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, an...
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ftdoajarticles:oai:doaj.org/article:383bf1611fb4497aaa42912652fce36d 2023-05-15T15:08:29+02:00 Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects Hnin Ei Thu Zahid Hussain Isa Naina Mohamed Ahmad Nazrun Shuid 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.225015 https://doaj.org/article/383bf1611fb4497aaa42912652fce36d EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=2;spage=89;epage=97;aulast=Thu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.225015 https://doaj.org/article/383bf1611fb4497aaa42912652fce36d Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 2, Pp 89-97 (2018) eurycoma longifolia jack pharmacokinetic profile pharmacodynamic algorithm eurycomanone quassinoids Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.225015 2022-12-31T04:31:01Z Eurycoma longifolia Jack (E. longifolia) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer properties. This review aims to overview the pharmacokinetic and a pharmacodynamic algorithm of E. longifolia and its bioactive components. Analysis of pharmacokinetic profile revealed that E. longifolia exhibit higher bioavailability, high volume of distribution, slow elimination rate, and does not show inhibitory effects on cytochrome P450 isoenzymes. E. longifolia has been used, alone or in combination with other pharmacological agents, in the form of crude extracts, standard extracts, or decoctions of different plant parts (i.e., herbs, shrubs, stem, leaves, and roots) for the treatment of various ailments in animals and humans. Among various bioactive constituents, eurycomanone has been found to be the most remarkable, super-stable, versatile, and most potent phytochemical (isolated or extracted from root extracts) against various types of animals and human diseases. Based on its well-established pharmacokinetic and pharmacodynamic profiles, we suggested that E. longifolia can be a well-accepted complementary and alternative medicine for the treatment of different types of human ailments. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 2 89 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
eurycoma longifolia jack pharmacokinetic profile pharmacodynamic algorithm eurycomanone quassinoids Arctic medicine. Tropical medicine RC955-962 |
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eurycoma longifolia jack pharmacokinetic profile pharmacodynamic algorithm eurycomanone quassinoids Arctic medicine. Tropical medicine RC955-962 Hnin Ei Thu Zahid Hussain Isa Naina Mohamed Ahmad Nazrun Shuid Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects |
topic_facet |
eurycoma longifolia jack pharmacokinetic profile pharmacodynamic algorithm eurycomanone quassinoids Arctic medicine. Tropical medicine RC955-962 |
description |
Eurycoma longifolia Jack (E. longifolia) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer properties. This review aims to overview the pharmacokinetic and a pharmacodynamic algorithm of E. longifolia and its bioactive components. Analysis of pharmacokinetic profile revealed that E. longifolia exhibit higher bioavailability, high volume of distribution, slow elimination rate, and does not show inhibitory effects on cytochrome P450 isoenzymes. E. longifolia has been used, alone or in combination with other pharmacological agents, in the form of crude extracts, standard extracts, or decoctions of different plant parts (i.e., herbs, shrubs, stem, leaves, and roots) for the treatment of various ailments in animals and humans. Among various bioactive constituents, eurycomanone has been found to be the most remarkable, super-stable, versatile, and most potent phytochemical (isolated or extracted from root extracts) against various types of animals and human diseases. Based on its well-established pharmacokinetic and pharmacodynamic profiles, we suggested that E. longifolia can be a well-accepted complementary and alternative medicine for the treatment of different types of human ailments. |
format |
Article in Journal/Newspaper |
author |
Hnin Ei Thu Zahid Hussain Isa Naina Mohamed Ahmad Nazrun Shuid |
author_facet |
Hnin Ei Thu Zahid Hussain Isa Naina Mohamed Ahmad Nazrun Shuid |
author_sort |
Hnin Ei Thu |
title |
Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects |
title_short |
Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects |
title_full |
Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects |
title_fullStr |
Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects |
title_full_unstemmed |
Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects |
title_sort |
exploring dynamic biomedical algorithm of eurycoma longifolia jack and its bioactive phytochemicals: a review of pharmacokinetic and pharmacodynamic implications and future prospects |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.225015 https://doaj.org/article/383bf1611fb4497aaa42912652fce36d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 2, Pp 89-97 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=2;spage=89;epage=97;aulast=Thu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.225015 https://doaj.org/article/383bf1611fb4497aaa42912652fce36d |
op_doi |
https://doi.org/10.4103/1995-7645.225015 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
2 |
container_start_page |
89 |
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1766339844463656960 |