Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China.
Climate exerts complex influences on leptospirosis transmission, affecting human behavior, zoonotic host population dynamics, and survival of the pathogen in the environment. Here, we describe the spatiotemporal distribution of leptospirosis incidence reported to China's National Infectious Dis...
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ftdoajarticles:oai:doaj.org/article:37f726d1d9b04f12965eab0265856219 2023-05-15T15:10:47+02:00 Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. Karina Cucchi Runyou Liu Philip A Collender Qu Cheng Charles Li Christopher M Hoover Howard H Chang Song Liang Changhong Yang Justin V Remais 2019-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007968 https://doaj.org/article/37f726d1d9b04f12965eab0265856219 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007968 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007968 https://doaj.org/article/37f726d1d9b04f12965eab0265856219 PLoS Neglected Tropical Diseases, Vol 13, Iss 12, p e0007968 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007968 2022-12-31T07:50:09Z Climate exerts complex influences on leptospirosis transmission, affecting human behavior, zoonotic host population dynamics, and survival of the pathogen in the environment. Here, we describe the spatiotemporal distribution of leptospirosis incidence reported to China's National Infectious Disease Surveillance System from 2004-2014 in an endemic region in western China, and employ distributed lag models at annual and sub-annual scales to analyze its association with hydroclimatic risk factors and explore evidence for the potential role of a soil reservoir in the transmission of Leptospira spp. More than 97% of the 2,934 reported leptospirosis cases occurred during the harvest season between August and October, and most commonly affected farmers (83%). Using a distributed lag Poisson regression framework, we characterized incidence rate ratios (IRRs) associated with interquartile range increases in precipitation of 3.45 (95% confidence interval 2.57-4.64) over 0-1-year lags, and 1.90 (1.18-3.06) over 0-15-week lags. Adjusting for soil moisture decreased IRRs for precipitation at both timescales (yearly adjusted IRR: 1.05, 0.74-1.49; weekly adjusted IRR: 1.36, 0.72-2.57), suggesting precipitation effects may be mediated through soil moisture. Increased soil moisture was positively associated with leptospirosis at both timescales, suggesting that the survival of pathogenic Leptospira spp. in moist soils may be a critical control on harvest-associated leptospirosis transmission in the study region. These results support the hypothesis that soils may serve as an environmental reservoir and may play a significant yet underrecognized role in leptospirosis transmission. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 12 e0007968 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Karina Cucchi Runyou Liu Philip A Collender Qu Cheng Charles Li Christopher M Hoover Howard H Chang Song Liang Changhong Yang Justin V Remais Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Climate exerts complex influences on leptospirosis transmission, affecting human behavior, zoonotic host population dynamics, and survival of the pathogen in the environment. Here, we describe the spatiotemporal distribution of leptospirosis incidence reported to China's National Infectious Disease Surveillance System from 2004-2014 in an endemic region in western China, and employ distributed lag models at annual and sub-annual scales to analyze its association with hydroclimatic risk factors and explore evidence for the potential role of a soil reservoir in the transmission of Leptospira spp. More than 97% of the 2,934 reported leptospirosis cases occurred during the harvest season between August and October, and most commonly affected farmers (83%). Using a distributed lag Poisson regression framework, we characterized incidence rate ratios (IRRs) associated with interquartile range increases in precipitation of 3.45 (95% confidence interval 2.57-4.64) over 0-1-year lags, and 1.90 (1.18-3.06) over 0-15-week lags. Adjusting for soil moisture decreased IRRs for precipitation at both timescales (yearly adjusted IRR: 1.05, 0.74-1.49; weekly adjusted IRR: 1.36, 0.72-2.57), suggesting precipitation effects may be mediated through soil moisture. Increased soil moisture was positively associated with leptospirosis at both timescales, suggesting that the survival of pathogenic Leptospira spp. in moist soils may be a critical control on harvest-associated leptospirosis transmission in the study region. These results support the hypothesis that soils may serve as an environmental reservoir and may play a significant yet underrecognized role in leptospirosis transmission. |
format |
Article in Journal/Newspaper |
author |
Karina Cucchi Runyou Liu Philip A Collender Qu Cheng Charles Li Christopher M Hoover Howard H Chang Song Liang Changhong Yang Justin V Remais |
author_facet |
Karina Cucchi Runyou Liu Philip A Collender Qu Cheng Charles Li Christopher M Hoover Howard H Chang Song Liang Changhong Yang Justin V Remais |
author_sort |
Karina Cucchi |
title |
Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. |
title_short |
Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. |
title_full |
Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. |
title_fullStr |
Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. |
title_full_unstemmed |
Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. |
title_sort |
hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic leptospira spp. in rural western china. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007968 https://doaj.org/article/37f726d1d9b04f12965eab0265856219 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 12, p e0007968 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007968 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007968 https://doaj.org/article/37f726d1d9b04f12965eab0265856219 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007968 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
12 |
container_start_page |
e0007968 |
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1766341738047209472 |