Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Jennifer Timm, Cristina Bosch-Navarrete, Eliseo Recio, Joanne E Nettleship, Heather Rada, Dolores González-Pacanowska, Keith S Wilson
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2015
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Holo
• Online Access: https://doi.org/10.1371/journal.pntd.0003781; https://doaj.org/article/3756b357c9194de8b705af699ce4ab89

Leishmania spp. is a protozoan parasite and the causative agent of leishmaniasis. Thymidine kinase (TK) catalyses the transfer of the γ-phosphate of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP). L. major Type II TK (LmTK) has been previously shown to be important for i...