Antioxidant and anti-inflammatory activities of Orostachys japonicus
Objective: To determine the bioactive compounds of Orostachys japonicus (O. japonicus) (Maxim.) A. Berger extraction by different solvents (70% ethanol or water) and to evaluate the in vitro antioxidant and anti-inflammatory activities. Methods: Total polyphenol, flavonoid, and anthocyanin contents...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2020
|
Subjects: | |
Online Access: | https://doi.org/10.4103/2221-1691.294092 https://doaj.org/article/374ad40b5d454122a879377a3b05d86e |
id |
ftdoajarticles:oai:doaj.org/article:374ad40b5d454122a879377a3b05d86e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:374ad40b5d454122a879377a3b05d86e 2023-05-15T15:07:16+02:00 Antioxidant and anti-inflammatory activities of Orostachys japonicus Eun-Sun Hwang Nhuan Do Thi 2020-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.294092 https://doaj.org/article/374ad40b5d454122a879377a3b05d86e EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=11;spage=516;epage=522;aulast=Hwang https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.294092 https://doaj.org/article/374ad40b5d454122a879377a3b05d86e Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 11, Pp 516-522 (2020) orostachys japonicus antioxidant raw 264.7 anti-inflammation nitrix oxide Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2020 ftdoajarticles https://doi.org/10.4103/2221-1691.294092 2022-12-31T08:40:04Z Objective: To determine the bioactive compounds of Orostachys japonicus (O. japonicus) (Maxim.) A. Berger extraction by different solvents (70% ethanol or water) and to evaluate the in vitro antioxidant and anti-inflammatory activities. Methods: Total polyphenol, flavonoid, and anthocyanin contents in O. japonicus extract were measured. Antioxidant activities were determined by DPPH, ABTS, and superoxide radical-scavenging ability assays. Anti-inflammatory activities were evaluated by nitric oxide production, tumor necrosis factor-α, and interleukin-6 expression techniques. Results: Extraction with 70% ethanol yielded the highest total polyphenol (60.03 mg/g dry weight) and flavonoid (55.50 mg/g dry weight) contents. The total anthocyanin contents in 70% ethanol and water extracts were 57.25 and 91.71 mg/g dry weight, respectively. The 70% ethanol extract also showed stronger antioxidant activity than the water extract. Antioxidant activity and reducing power increased with the increasing concentration of O. japonicus extract. O. japonicus extract at 0-400 μg/mL did not affect the growth of RAW 264.7 cells, whereas dose-dependent inhibition of nitric oxide, tumor necrosis factor-a, and interleukin-6 production was observed. Conclusions: O. japonicus inhibits oxidative and inflammatory reactions with potentially positive health-related effects. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 10 11 516 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
orostachys japonicus antioxidant raw 264.7 anti-inflammation nitrix oxide Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
orostachys japonicus antioxidant raw 264.7 anti-inflammation nitrix oxide Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Eun-Sun Hwang Nhuan Do Thi Antioxidant and anti-inflammatory activities of Orostachys japonicus |
topic_facet |
orostachys japonicus antioxidant raw 264.7 anti-inflammation nitrix oxide Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To determine the bioactive compounds of Orostachys japonicus (O. japonicus) (Maxim.) A. Berger extraction by different solvents (70% ethanol or water) and to evaluate the in vitro antioxidant and anti-inflammatory activities. Methods: Total polyphenol, flavonoid, and anthocyanin contents in O. japonicus extract were measured. Antioxidant activities were determined by DPPH, ABTS, and superoxide radical-scavenging ability assays. Anti-inflammatory activities were evaluated by nitric oxide production, tumor necrosis factor-α, and interleukin-6 expression techniques. Results: Extraction with 70% ethanol yielded the highest total polyphenol (60.03 mg/g dry weight) and flavonoid (55.50 mg/g dry weight) contents. The total anthocyanin contents in 70% ethanol and water extracts were 57.25 and 91.71 mg/g dry weight, respectively. The 70% ethanol extract also showed stronger antioxidant activity than the water extract. Antioxidant activity and reducing power increased with the increasing concentration of O. japonicus extract. O. japonicus extract at 0-400 μg/mL did not affect the growth of RAW 264.7 cells, whereas dose-dependent inhibition of nitric oxide, tumor necrosis factor-a, and interleukin-6 production was observed. Conclusions: O. japonicus inhibits oxidative and inflammatory reactions with potentially positive health-related effects. |
format |
Article in Journal/Newspaper |
author |
Eun-Sun Hwang Nhuan Do Thi |
author_facet |
Eun-Sun Hwang Nhuan Do Thi |
author_sort |
Eun-Sun Hwang |
title |
Antioxidant and anti-inflammatory activities of Orostachys japonicus |
title_short |
Antioxidant and anti-inflammatory activities of Orostachys japonicus |
title_full |
Antioxidant and anti-inflammatory activities of Orostachys japonicus |
title_fullStr |
Antioxidant and anti-inflammatory activities of Orostachys japonicus |
title_full_unstemmed |
Antioxidant and anti-inflammatory activities of Orostachys japonicus |
title_sort |
antioxidant and anti-inflammatory activities of orostachys japonicus |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/2221-1691.294092 https://doaj.org/article/374ad40b5d454122a879377a3b05d86e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 11, Pp 516-522 (2020) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=11;spage=516;epage=522;aulast=Hwang https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.294092 https://doaj.org/article/374ad40b5d454122a879377a3b05d86e |
op_doi |
https://doi.org/10.4103/2221-1691.294092 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
10 |
container_issue |
11 |
container_start_page |
516 |
_version_ |
1766338815827378176 |