Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations
Abstract Malaria remains a major cause of morbidity and mortality in Africa, particularly in children under five years of age. Availability of effective anti-malarial drug treatment is a cornerstone for malaria control and eventual malaria elimination. Artemisinin-based combination therapy (ACT) is...
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ftdoajarticles:oai:doaj.org/article:373dc6e418ec419dbdb510e2c5cde0a6 2023-05-15T15:07:36+02:00 Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations Paulina Tindana Freek de Haan Chanaki Amaratunga Mehul Dhorda Rob W. van der Pluijm Arjen M. Dondorp Phaik Yeong Cheah 2021-02-01T00:00:00Z https://doi.org/10.1186/s12936-021-03649-7 https://doaj.org/article/373dc6e418ec419dbdb510e2c5cde0a6 EN eng BMC https://doi.org/10.1186/s12936-021-03649-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03649-7 1475-2875 https://doaj.org/article/373dc6e418ec419dbdb510e2c5cde0a6 Malaria Journal, Vol 20, Iss 1, Pp 1-7 (2021) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03649-7 2022-12-31T06:44:24Z Abstract Malaria remains a major cause of morbidity and mortality in Africa, particularly in children under five years of age. Availability of effective anti-malarial drug treatment is a cornerstone for malaria control and eventual malaria elimination. Artemisinin-based combination therapy (ACT) is worldwide the first-line treatment for uncomplicated falciparum malaria, but the ACT drugs are starting to fail in Southeast Asia because of drug resistance. Resistance to artemisinins and their partner drugs could spread from Southeast Asia to Africa or emerge locally, jeopardizing the progress made in malaria control with the increasing deployment of ACT in Africa. The development of triple artemisinin-based combination therapy (TACT) could contribute to mitigating the risks of artemisinin and partner drug resistance on the African continent. However, there are pertinent ethical and practical issues that ought to be taken into consideration. In this paper, the most important ethical tensions, some implementation practicalities and preliminary thoughts on addressing them are discussed. The discussion draws upon data from randomized clinical studies using TACT combined with ethical principles, published literature and lessons learned from the introduction of artemisinin-based combinations in African markets. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Paulina Tindana Freek de Haan Chanaki Amaratunga Mehul Dhorda Rob W. van der Pluijm Arjen M. Dondorp Phaik Yeong Cheah Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Malaria remains a major cause of morbidity and mortality in Africa, particularly in children under five years of age. Availability of effective anti-malarial drug treatment is a cornerstone for malaria control and eventual malaria elimination. Artemisinin-based combination therapy (ACT) is worldwide the first-line treatment for uncomplicated falciparum malaria, but the ACT drugs are starting to fail in Southeast Asia because of drug resistance. Resistance to artemisinins and their partner drugs could spread from Southeast Asia to Africa or emerge locally, jeopardizing the progress made in malaria control with the increasing deployment of ACT in Africa. The development of triple artemisinin-based combination therapy (TACT) could contribute to mitigating the risks of artemisinin and partner drug resistance on the African continent. However, there are pertinent ethical and practical issues that ought to be taken into consideration. In this paper, the most important ethical tensions, some implementation practicalities and preliminary thoughts on addressing them are discussed. The discussion draws upon data from randomized clinical studies using TACT combined with ethical principles, published literature and lessons learned from the introduction of artemisinin-based combinations in African markets. |
format |
Article in Journal/Newspaper |
author |
Paulina Tindana Freek de Haan Chanaki Amaratunga Mehul Dhorda Rob W. van der Pluijm Arjen M. Dondorp Phaik Yeong Cheah |
author_facet |
Paulina Tindana Freek de Haan Chanaki Amaratunga Mehul Dhorda Rob W. van der Pluijm Arjen M. Dondorp Phaik Yeong Cheah |
author_sort |
Paulina Tindana |
title |
Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations |
title_short |
Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations |
title_full |
Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations |
title_fullStr |
Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations |
title_full_unstemmed |
Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations |
title_sort |
deploying triple artemisinin-based combination therapy (tact) for malaria treatment in africa: ethical and practical considerations |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03649-7 https://doaj.org/article/373dc6e418ec419dbdb510e2c5cde0a6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-7 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03649-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03649-7 1475-2875 https://doaj.org/article/373dc6e418ec419dbdb510e2c5cde0a6 |
op_doi |
https://doi.org/10.1186/s12936-021-03649-7 |
container_title |
Malaria Journal |
container_volume |
20 |
container_issue |
1 |
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1766339071250006016 |