Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study
Background: Docosahexaenoic acid (DHA) is a major constituent of neuronal and retinal membranes and plays a crucial role in brain and visual development within the first months of life. Dietary intakes are fundamental to provide neonates with adequate DHA supply; hence, maternal supplementation migh...
Published in: | Frontiers in Pediatrics |
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ftdoajarticles:oai:doaj.org/article:373891c737234e3a87d1305181bdbc63 2023-05-15T14:00:48+02:00 Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study Anna Giulia Cimatti Silvia Martini Alessandra Munarini Maximilano Zioutas Francesca Vitali Arianna Aceti Vilma Mantovani Giacomo Faldella Luigi Corvaglia 2018-12-01T00:00:00Z https://doi.org/10.3389/fped.2018.00407 https://doaj.org/article/373891c737234e3a87d1305181bdbc63 EN eng Frontiers Media S.A. https://www.frontiersin.org/article/10.3389/fped.2018.00407/full https://doaj.org/toc/2296-2360 2296-2360 doi:10.3389/fped.2018.00407 https://doaj.org/article/373891c737234e3a87d1305181bdbc63 Frontiers in Pediatrics, Vol 6 (2018) LCPUFA DHA AA EPA breast milk supplementation Pediatrics RJ1-570 article 2018 ftdoajarticles https://doi.org/10.3389/fped.2018.00407 2022-12-31T04:15:17Z Background: Docosahexaenoic acid (DHA) is a major constituent of neuronal and retinal membranes and plays a crucial role in brain and visual development within the first months of life. Dietary intakes are fundamental to provide neonates with adequate DHA supply; hence, maternal supplementation might represent a useful strategy to implement DHA contents in breast milk (BM), with possible benefits on neonatal neurodevelopment. Antarctic krill is a small crustacean rich in highly available phospholipid-bound DHA. This pilot study aimed to evaluate whether maternal supplementation with krill oil during breastfeeding increases long-chain polyunsaturated fatty acids (LCPUFAs) BM contents.Methods: Mothers of infants admitted to the Neonatal Intensive Care Unit were enrolled in this open, randomized-controlled study between 4 and 6 weeks after delivery and randomly allocated in 2 groups. Group 1 received an oral krill oil-based supplement providing 250 mg/day of DHA and 70 mg/day of eicosapentaenoic acid (EPA) for 30 days; group 2 served as control. BM samples from both groups were collected at baseline (T0) and day 30 (T1) and underwent a qualitative analysis of LCPUFAs composition by gas chromatography/mass spectrometry.Results: Sixteen breastfeeding women were included. Of these, 8 received krill-oil supplementation and 8 were randomized to the control group. Baseline percentage values of DHA (%DHA), arachidonic acid (), and EPA (%EPA) did not differ between groups. A significant increase in %DHA (T0: median 0.23% [IQR 0.19;0.38], T1:0.42% [0.32;0.49], p 0.012) and %EPA (T0: median 0.10% [IQR 0.04;0.11], T1:0.11% [0.04;0.15], p 0.036) and a significant reduction in (T0: median 0.48% [IQR 0.42;0.75], T1:0.43% [0.38;0.61], p 0.017) between T0 and T1 occurred in Group 1, whereas no difference was seen in Group 2. Consistently, a significant between-group difference was observed in percentage changes from baseline of DHA (Δ%DHA, group 1: median 64.2% [IQR 27.5;134.6], group 2: −7.8% [−12.1;−3.13], p 0.025) and EPA ... Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Directory of Open Access Journals: DOAJ Articles Antarctic Frontiers in Pediatrics 6 |
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collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
LCPUFA DHA AA EPA breast milk supplementation Pediatrics RJ1-570 |
spellingShingle |
LCPUFA DHA AA EPA breast milk supplementation Pediatrics RJ1-570 Anna Giulia Cimatti Silvia Martini Alessandra Munarini Maximilano Zioutas Francesca Vitali Arianna Aceti Vilma Mantovani Giacomo Faldella Luigi Corvaglia Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study |
topic_facet |
LCPUFA DHA AA EPA breast milk supplementation Pediatrics RJ1-570 |
description |
Background: Docosahexaenoic acid (DHA) is a major constituent of neuronal and retinal membranes and plays a crucial role in brain and visual development within the first months of life. Dietary intakes are fundamental to provide neonates with adequate DHA supply; hence, maternal supplementation might represent a useful strategy to implement DHA contents in breast milk (BM), with possible benefits on neonatal neurodevelopment. Antarctic krill is a small crustacean rich in highly available phospholipid-bound DHA. This pilot study aimed to evaluate whether maternal supplementation with krill oil during breastfeeding increases long-chain polyunsaturated fatty acids (LCPUFAs) BM contents.Methods: Mothers of infants admitted to the Neonatal Intensive Care Unit were enrolled in this open, randomized-controlled study between 4 and 6 weeks after delivery and randomly allocated in 2 groups. Group 1 received an oral krill oil-based supplement providing 250 mg/day of DHA and 70 mg/day of eicosapentaenoic acid (EPA) for 30 days; group 2 served as control. BM samples from both groups were collected at baseline (T0) and day 30 (T1) and underwent a qualitative analysis of LCPUFAs composition by gas chromatography/mass spectrometry.Results: Sixteen breastfeeding women were included. Of these, 8 received krill-oil supplementation and 8 were randomized to the control group. Baseline percentage values of DHA (%DHA), arachidonic acid (), and EPA (%EPA) did not differ between groups. A significant increase in %DHA (T0: median 0.23% [IQR 0.19;0.38], T1:0.42% [0.32;0.49], p 0.012) and %EPA (T0: median 0.10% [IQR 0.04;0.11], T1:0.11% [0.04;0.15], p 0.036) and a significant reduction in (T0: median 0.48% [IQR 0.42;0.75], T1:0.43% [0.38;0.61], p 0.017) between T0 and T1 occurred in Group 1, whereas no difference was seen in Group 2. Consistently, a significant between-group difference was observed in percentage changes from baseline of DHA (Δ%DHA, group 1: median 64.2% [IQR 27.5;134.6], group 2: −7.8% [−12.1;−3.13], p 0.025) and EPA ... |
format |
Article in Journal/Newspaper |
author |
Anna Giulia Cimatti Silvia Martini Alessandra Munarini Maximilano Zioutas Francesca Vitali Arianna Aceti Vilma Mantovani Giacomo Faldella Luigi Corvaglia |
author_facet |
Anna Giulia Cimatti Silvia Martini Alessandra Munarini Maximilano Zioutas Francesca Vitali Arianna Aceti Vilma Mantovani Giacomo Faldella Luigi Corvaglia |
author_sort |
Anna Giulia Cimatti |
title |
Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study |
title_short |
Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study |
title_full |
Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study |
title_fullStr |
Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study |
title_full_unstemmed |
Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study |
title_sort |
maternal supplementation with krill oil during breastfeeding and long-chain polyunsaturated fatty acids (lcpufas) composition of human milk: a feasibility study |
publisher |
Frontiers Media S.A. |
publishDate |
2018 |
url |
https://doi.org/10.3389/fped.2018.00407 https://doaj.org/article/373891c737234e3a87d1305181bdbc63 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
Frontiers in Pediatrics, Vol 6 (2018) |
op_relation |
https://www.frontiersin.org/article/10.3389/fped.2018.00407/full https://doaj.org/toc/2296-2360 2296-2360 doi:10.3389/fped.2018.00407 https://doaj.org/article/373891c737234e3a87d1305181bdbc63 |
op_doi |
https://doi.org/10.3389/fped.2018.00407 |
container_title |
Frontiers in Pediatrics |
container_volume |
6 |
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1766270143827017728 |