TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Roberto Rodrigues Ferreira, Rayane da Silva Abreu, Glaucia Vilar-Pereira, Wim Degrave, Marcelo Meuser-Batista, Nilma Valéria Caldeira Ferreira, Otacílio da Cruz Moreira, Natália Lins da Silva Gomes, Elen Mello de Souza, Isalira P Ramos, Sabine Bailly, Jean-Jacques Feige, Joseli Lannes-Vieira, Tania C de Araújo-Jorge, Mariana Caldas Waghabi
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2019
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Gata
• Online Access: https://doi.org/10.1371/journal.pntd.0007602; https://doaj.org/article/3736842f86a242e598ff553363a576b7

TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-β signaling pathway is activated in the cardiac tissue of chronic phase patients and is associated with an increase in extracellular matrix protein expression. The aim of this study was to investigate the effec...