VKORC1 gene -1639 G/A and 1173 C/Т polymorphisms in Nenets autonomous district indigenous population

According to the data obtained the VKORC1 gene polymorphism prevalence in the native population of the Nenets autonomous region differed significantly from that in the Arkhangelsk population. The homozygous form of 1173T allele prevailed in the nenets. This may be protective against thrombosis but i...

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Bibliographic Details
Published in:The Scientific Notes of the I. P. Pavlov St. Petersburg State Medical University
Main Authors: P. A. Lavrinov, N. I. Belova, N. A. Vorobyeva
Format: Article in Journal/Newspaper
Language:Russian
Published: Academician I.P. Pavlov First St. Petersburg State Medical University 2014
Subjects:
ненцы
vkorc1
витамин к
гемостаз
варфаринотерапия
nenets
vitamin k
hemostasis
warfarinotherapy
Medicine (General)
R5-920
Arkhangelsk
Ненцы
Online Access:https://doi.org/10.24884/1607-4181-2014-21-2-33-36
https://doaj.org/article/372470ffb4044655bdae6b4320159fbe
Description
Summary:According to the data obtained the VKORC1 gene polymorphism prevalence in the native population of the Nenets autonomous region differed significantly from that in the Arkhangelsk population. The homozygous form of 1173T allele prevailed in the nenets. This may be protective against thrombosis but it increases the risk of artery calcification and of indirect overdosing of anticoagulants.

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