Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii
Abstract Background Malaria parasites are known to be vulnerable to oxidative stress. In this study, the effects of the administration of α-tocopheryloxy acetic acid (α-TEA), which is a vitamin E analogue mitocan, on Plasmodium yoelii infection in mice were examined. Methods Alpha-TEA was mixed with...
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ftdoajarticles:oai:doaj.org/article:3680af0046f4496f824c5cad9fcc45b6 2023-05-15T15:18:14+02:00 Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii Kasumi Kawamura Aiko Kume Rika Umemiya-Shirafuji Shunji Kasai Hiroshi Suzuki 2021-06-01T00:00:00Z https://doi.org/10.1186/s12936-021-03817-9 https://doaj.org/article/3680af0046f4496f824c5cad9fcc45b6 EN eng BMC https://doi.org/10.1186/s12936-021-03817-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03817-9 1475-2875 https://doaj.org/article/3680af0046f4496f824c5cad9fcc45b6 Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021) α-tocopheryloxy acetic acid Mice Plasmodium yoelii Reactive oxygen species Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03817-9 2022-12-31T11:25:25Z Abstract Background Malaria parasites are known to be vulnerable to oxidative stress. In this study, the effects of the administration of α-tocopheryloxy acetic acid (α-TEA), which is a vitamin E analogue mitocan, on Plasmodium yoelii infection in mice were examined. Methods Alpha-TEA was mixed with diet and fed to C57BL/6J mice before and/or after infection. For parasite infection, 4 × 104 red blood cells infected with P. yoelii (strain 17XL) were inoculated by intraperitoneal injection. In another series of experiment, the effect of the oral administration of α-TEA on P. yoelii 17XL infection in mice was examined. Finally, the combined effect of α-TEA and dihydroartemisinin or chloroquine on P. yoelii 17XL infection was examined. Results When 0.25% α-TEA was mixed with the diet for 7 days before infection and 14 days after infection (in total for 21 days), for 14 days after infection, and for 11 days from the third day after infection, all P. yoelii 17XL-infected mice survived during the observation period. However, all control mice died within 12 days after infection. These results indicated that α-TEA functions effectively even when administered post-infection. The oral administration of α-TEA for P. yoelii 17XL infection was also significant. Although the infected mice in the solvent control died within 10 days after infection, 90% of the mice infected with P. yoelii 17XL survived during the observation period when treated with 10 mg/head/day of α-TEA for 3 days from day 3 after infection. Although the combined effect of α-TEA and dihydroartemisinin (DHA) or chloroquine on P. yoelii 17XL infection was significant, no synergistic or additive effects were observed from the survival curve. Conclusions This study showed the beneficial effects of α-TEA on the experimental infection of mice with P. yoelii 17XL. The stimulatory action of α-TEA on mitochondria and the accompanying reactions, such as reactive oxygen species production, and induction of apoptosis might have some effect on malarial infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
α-tocopheryloxy acetic acid Mice Plasmodium yoelii Reactive oxygen species Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
α-tocopheryloxy acetic acid Mice Plasmodium yoelii Reactive oxygen species Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kasumi Kawamura Aiko Kume Rika Umemiya-Shirafuji Shunji Kasai Hiroshi Suzuki Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii |
topic_facet |
α-tocopheryloxy acetic acid Mice Plasmodium yoelii Reactive oxygen species Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria parasites are known to be vulnerable to oxidative stress. In this study, the effects of the administration of α-tocopheryloxy acetic acid (α-TEA), which is a vitamin E analogue mitocan, on Plasmodium yoelii infection in mice were examined. Methods Alpha-TEA was mixed with diet and fed to C57BL/6J mice before and/or after infection. For parasite infection, 4 × 104 red blood cells infected with P. yoelii (strain 17XL) were inoculated by intraperitoneal injection. In another series of experiment, the effect of the oral administration of α-TEA on P. yoelii 17XL infection in mice was examined. Finally, the combined effect of α-TEA and dihydroartemisinin or chloroquine on P. yoelii 17XL infection was examined. Results When 0.25% α-TEA was mixed with the diet for 7 days before infection and 14 days after infection (in total for 21 days), for 14 days after infection, and for 11 days from the third day after infection, all P. yoelii 17XL-infected mice survived during the observation period. However, all control mice died within 12 days after infection. These results indicated that α-TEA functions effectively even when administered post-infection. The oral administration of α-TEA for P. yoelii 17XL infection was also significant. Although the infected mice in the solvent control died within 10 days after infection, 90% of the mice infected with P. yoelii 17XL survived during the observation period when treated with 10 mg/head/day of α-TEA for 3 days from day 3 after infection. Although the combined effect of α-TEA and dihydroartemisinin (DHA) or chloroquine on P. yoelii 17XL infection was significant, no synergistic or additive effects were observed from the survival curve. Conclusions This study showed the beneficial effects of α-TEA on the experimental infection of mice with P. yoelii 17XL. The stimulatory action of α-TEA on mitochondria and the accompanying reactions, such as reactive oxygen species production, and induction of apoptosis might have some effect on malarial infection. |
format |
Article in Journal/Newspaper |
author |
Kasumi Kawamura Aiko Kume Rika Umemiya-Shirafuji Shunji Kasai Hiroshi Suzuki |
author_facet |
Kasumi Kawamura Aiko Kume Rika Umemiya-Shirafuji Shunji Kasai Hiroshi Suzuki |
author_sort |
Kasumi Kawamura |
title |
Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii |
title_short |
Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii |
title_full |
Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii |
title_fullStr |
Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii |
title_full_unstemmed |
Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii |
title_sort |
effect of α-tocopheryloxy acetic acid, a vitamin e derivative mitocan, on the experimental infection of mice with plasmodium yoelii |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03817-9 https://doaj.org/article/3680af0046f4496f824c5cad9fcc45b6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03817-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03817-9 1475-2875 https://doaj.org/article/3680af0046f4496f824c5cad9fcc45b6 |
op_doi |
https://doi.org/10.1186/s12936-021-03817-9 |
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Malaria Journal |
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20 |
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1 |
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1766348447637569536 |