Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção
The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reducti...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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2004
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Online Access: | https://doi.org/10.1590/S0036-46652004000400010 https://doaj.org/article/363e1f053d984e2f9547fd777baccf9c |
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ftdoajarticles:oai:doaj.org/article:363e1f053d984e2f9547fd777baccf9c 2024-09-09T19:26:12+00:00 Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção Fabio Ribeiro Rômulo Teixeira de Mello Carlos Alberto Pereira Tavares John Robert Kusel Paulo Marcos Zech Coelho 2004-08-01T00:00:00Z https://doi.org/10.1590/S0036-46652004000400010 https://doaj.org/article/363e1f053d984e2f9547fd777baccf9c EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000400010 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652004000400010 0036-4665 1678-9946 https://doaj.org/article/363e1f053d984e2f9547fd777baccf9c Revista do Instituto de Medicina Tropical de São Paulo, Vol 46, Iss 4, Pp 231-233 (2004) Schistosoma mansoni Praziquantel Immune Response Concomitant Immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2004 ftdoajarticles https://doi.org/10.1590/S0036-46652004000400010 2024-08-05T17:49:31Z The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase. A interação entre a resposta imune específica ao Schistosoma mansoni e praziquantel (PZQ) foi avaliada em modelo murino. Em camundongos portadores de imunidade concomitante, parasitos com 6 dias de idade e tratados com PZQ, foram eliminados mais eficazmente do que parasitos de apenas 24 h, apesar de ambos mostrarem uma redução significativa da carga parasitária quando comparados com os respectivos controles tratados. Estes resultados mostram que o PZQ pode ser eficaz nos estágios de pele e pulmão durante o desenvolvimento do parasita, agindo principalmente com uma resposta imune específica estabelecida e, particularmente, na fase pulmonar. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 46 4 231 233 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Schistosoma mansoni Praziquantel Immune Response Concomitant Immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosoma mansoni Praziquantel Immune Response Concomitant Immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Fabio Ribeiro Rômulo Teixeira de Mello Carlos Alberto Pereira Tavares John Robert Kusel Paulo Marcos Zech Coelho Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção |
topic_facet |
Schistosoma mansoni Praziquantel Immune Response Concomitant Immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase. A interação entre a resposta imune específica ao Schistosoma mansoni e praziquantel (PZQ) foi avaliada em modelo murino. Em camundongos portadores de imunidade concomitante, parasitos com 6 dias de idade e tratados com PZQ, foram eliminados mais eficazmente do que parasitos de apenas 24 h, apesar de ambos mostrarem uma redução significativa da carga parasitária quando comparados com os respectivos controles tratados. Estes resultados mostram que o PZQ pode ser eficaz nos estágios de pele e pulmão durante o desenvolvimento do parasita, agindo principalmente com uma resposta imune específica estabelecida e, particularmente, na fase pulmonar. |
format |
Article in Journal/Newspaper |
author |
Fabio Ribeiro Rômulo Teixeira de Mello Carlos Alberto Pereira Tavares John Robert Kusel Paulo Marcos Zech Coelho |
author_facet |
Fabio Ribeiro Rômulo Teixeira de Mello Carlos Alberto Pereira Tavares John Robert Kusel Paulo Marcos Zech Coelho |
author_sort |
Fabio Ribeiro |
title |
Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção |
title_short |
Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção |
title_full |
Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção |
title_fullStr |
Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção |
title_full_unstemmed |
Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection Ação sinergística do praziquantel e resposta imune específica do hospedeiro ao Schistosoma mansoni em diferentes fases da infecção |
title_sort |
synergistic action of praziquantel and host specific immune response against schistosoma mansoni at different phases of infection ação sinergística do praziquantel e resposta imune específica do hospedeiro ao schistosoma mansoni em diferentes fases da infecção |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2004 |
url |
https://doi.org/10.1590/S0036-46652004000400010 https://doaj.org/article/363e1f053d984e2f9547fd777baccf9c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 46, Iss 4, Pp 231-233 (2004) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000400010 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652004000400010 0036-4665 1678-9946 https://doaj.org/article/363e1f053d984e2f9547fd777baccf9c |
op_doi |
https://doi.org/10.1590/S0036-46652004000400010 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
46 |
container_issue |
4 |
container_start_page |
231 |
op_container_end_page |
233 |
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