Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain
Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuad...
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ftdoajarticles:oai:doaj.org/article:358d7e0928544bb598f59b7efe73994d 2023-05-15T15:05:12+02:00 Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain Luisa Z Moreno Fabiana Miraglia Ana P Loureiro Frederico S Kremer Marcus R Eslabao Odir A Dellagostin Walter Lilenbaum Silvio A Vasconcellos Marcos B Heinemann Andrea M Moreno 2018-03-01T00:00:00Z https://doi.org/10.1590/0074-02760170444 https://doaj.org/article/358d7e0928544bb598f59b7efe73994d EN eng Instituto Oswaldo Cruz, Ministério da Saúde http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000500600&lng=en&tlng=en https://doaj.org/toc/1678-8060 1678-8060 doi:10.1590/0074-02760170444 https://doaj.org/article/358d7e0928544bb598f59b7efe73994d Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 5 (2018) Leptospira inadai serogroup Lyme comparative genomic analysis Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 article 2018 ftdoajarticles https://doi.org/10.1590/0074-02760170444 2023-01-08T01:34:15Z Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation. The M34/99 strain presented high similarity with L. inadai serogroup Lyme human reference indicating that animal strain could also infect humans, although it does not represent high risk of severe disease. An extrachromosomal sequence was also identified in M34/99 strain and presented high identity with previously described L. inadai phage LinZ_10, suggesting that phage-like extrachromosomal sequence may be another feature of this understudied species. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Memórias do Instituto Oswaldo Cruz 113 5 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Leptospira inadai serogroup Lyme comparative genomic analysis Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
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Leptospira inadai serogroup Lyme comparative genomic analysis Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 Luisa Z Moreno Fabiana Miraglia Ana P Loureiro Frederico S Kremer Marcus R Eslabao Odir A Dellagostin Walter Lilenbaum Silvio A Vasconcellos Marcos B Heinemann Andrea M Moreno Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain |
topic_facet |
Leptospira inadai serogroup Lyme comparative genomic analysis Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
description |
Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation. The M34/99 strain presented high similarity with L. inadai serogroup Lyme human reference indicating that animal strain could also infect humans, although it does not represent high risk of severe disease. An extrachromosomal sequence was also identified in M34/99 strain and presented high identity with previously described L. inadai phage LinZ_10, suggesting that phage-like extrachromosomal sequence may be another feature of this understudied species. |
format |
Article in Journal/Newspaper |
author |
Luisa Z Moreno Fabiana Miraglia Ana P Loureiro Frederico S Kremer Marcus R Eslabao Odir A Dellagostin Walter Lilenbaum Silvio A Vasconcellos Marcos B Heinemann Andrea M Moreno |
author_facet |
Luisa Z Moreno Fabiana Miraglia Ana P Loureiro Frederico S Kremer Marcus R Eslabao Odir A Dellagostin Walter Lilenbaum Silvio A Vasconcellos Marcos B Heinemann Andrea M Moreno |
author_sort |
Luisa Z Moreno |
title |
Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain |
title_short |
Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain |
title_full |
Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain |
title_fullStr |
Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain |
title_full_unstemmed |
Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain |
title_sort |
genomic characterisation of leptospira inadai serogroup lyme isolated from captured rat in brazil and comparative analysis with human reference strain |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2018 |
url |
https://doi.org/10.1590/0074-02760170444 https://doaj.org/article/358d7e0928544bb598f59b7efe73994d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 5 (2018) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000500600&lng=en&tlng=en https://doaj.org/toc/1678-8060 1678-8060 doi:10.1590/0074-02760170444 https://doaj.org/article/358d7e0928544bb598f59b7efe73994d |
op_doi |
https://doi.org/10.1590/0074-02760170444 |
container_title |
Memórias do Instituto Oswaldo Cruz |
container_volume |
113 |
container_issue |
5 |
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1766336938889969664 |