Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients
Antibodies to a number of parasite antigens are found in schistosomiasis patients, and antibodies to early developmental stages were demonstrated to be efficient immunologic markers for the diagnosis of schistosomiasis. In the present study, decay patterns of IgM and IgG antibodies against cercariae...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1997
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Online Access: | https://doi.org/10.1590/S0036-46651997000500005 https://doaj.org/article/3574f2feed3449fba2c3d325ae3bd57e |
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ftdoajarticles:oai:doaj.org/article:3574f2feed3449fba2c3d325ae3bd57e 2024-09-09T19:28:06+00:00 Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients Herminia Yohko KANAMURA Sumie HOSHINO-SHIMIZU Regina Tomie KIMURA Tokiko Kyomen MATSUMOTO Luiz Caetano da SILVA Dirce Mary Correa LIMA Clarice Pires ABRANTES-LEMOS 1997-09-01T00:00:00Z https://doi.org/10.1590/S0036-46651997000500005 https://doaj.org/article/3574f2feed3449fba2c3d325ae3bd57e EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000500005 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651997000500005 0036-4665 1678-9946 https://doaj.org/article/3574f2feed3449fba2c3d325ae3bd57e Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 5, p 271 (1997) Schistosomiasis mansoni Antibody decay Chemotherapy Anti-cercaria Anti-schistosomulum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1997 ftdoajarticles https://doi.org/10.1590/S0036-46651997000500005 2024-08-05T17:49:31Z Antibodies to a number of parasite antigens are found in schistosomiasis patients, and antibodies to early developmental stages were demonstrated to be efficient immunologic markers for the diagnosis of schistosomiasis. In the present study, decay patterns of IgM and IgG antibodies against cercariae and schistosomula were investigated, in comparison to antibodies against worms and eggs in schistosomiasis patients after chemotherapy, for an investigation of seroepidemiologic aspects. Data obtained in the study of 359 serum samples from patients with Schistosoma mansoni infection, noninfected individuals, and patients followed-up for a period of 12 to 15 months after treatment provided the basis to postulate a general pattern for the kinetics of antibody decay. Before treatment, the antibody pattern was represented by a unimodal curve, which shifted to a bimodal curve after treatment, and ended with a unimodal curve similar to that for the noninfected group. Different types of antibodies were classified into four categories according to their decay features, and anti-schistosomulum IgM was classified into the moderate-decay caterogy, whereas other antibodies to early parasite stages were classified into the slow-decay category. The present methodology permits the identification of the most suitable antibodies to be detected in field control programs for schistosomiasis or other parasitoses Em pacientes com esquistossomose, são encontrados anticorpos contra grande número de antígenos parasitários, e aqueles contra formas evolutivas jovens do parasita demonstraram que eram eficientes marcadores imunológicos para o diagnóstico da esquistossomose. Padrões de queda de anticorpos IgM e IgG contra cercária e esquistossômulo foram aqui estudados, comparativamente aos dos anticorpos contra verme e ovo, em pacientes esquistossomóticos após quimioterapia, abordando aspectos soroepidemiológicos. Dados obtidos no estudo de 359 amostras de soros, pertencentes a pacientes infectados por Schistosoma mansoni, indivíduos não ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 39 5 271 278 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Schistosomiasis mansoni Antibody decay Chemotherapy Anti-cercaria Anti-schistosomulum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosomiasis mansoni Antibody decay Chemotherapy Anti-cercaria Anti-schistosomulum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Herminia Yohko KANAMURA Sumie HOSHINO-SHIMIZU Regina Tomie KIMURA Tokiko Kyomen MATSUMOTO Luiz Caetano da SILVA Dirce Mary Correa LIMA Clarice Pires ABRANTES-LEMOS Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
topic_facet |
Schistosomiasis mansoni Antibody decay Chemotherapy Anti-cercaria Anti-schistosomulum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Antibodies to a number of parasite antigens are found in schistosomiasis patients, and antibodies to early developmental stages were demonstrated to be efficient immunologic markers for the diagnosis of schistosomiasis. In the present study, decay patterns of IgM and IgG antibodies against cercariae and schistosomula were investigated, in comparison to antibodies against worms and eggs in schistosomiasis patients after chemotherapy, for an investigation of seroepidemiologic aspects. Data obtained in the study of 359 serum samples from patients with Schistosoma mansoni infection, noninfected individuals, and patients followed-up for a period of 12 to 15 months after treatment provided the basis to postulate a general pattern for the kinetics of antibody decay. Before treatment, the antibody pattern was represented by a unimodal curve, which shifted to a bimodal curve after treatment, and ended with a unimodal curve similar to that for the noninfected group. Different types of antibodies were classified into four categories according to their decay features, and anti-schistosomulum IgM was classified into the moderate-decay caterogy, whereas other antibodies to early parasite stages were classified into the slow-decay category. The present methodology permits the identification of the most suitable antibodies to be detected in field control programs for schistosomiasis or other parasitoses Em pacientes com esquistossomose, são encontrados anticorpos contra grande número de antígenos parasitários, e aqueles contra formas evolutivas jovens do parasita demonstraram que eram eficientes marcadores imunológicos para o diagnóstico da esquistossomose. Padrões de queda de anticorpos IgM e IgG contra cercária e esquistossômulo foram aqui estudados, comparativamente aos dos anticorpos contra verme e ovo, em pacientes esquistossomóticos após quimioterapia, abordando aspectos soroepidemiológicos. Dados obtidos no estudo de 359 amostras de soros, pertencentes a pacientes infectados por Schistosoma mansoni, indivíduos não ... |
format |
Article in Journal/Newspaper |
author |
Herminia Yohko KANAMURA Sumie HOSHINO-SHIMIZU Regina Tomie KIMURA Tokiko Kyomen MATSUMOTO Luiz Caetano da SILVA Dirce Mary Correa LIMA Clarice Pires ABRANTES-LEMOS |
author_facet |
Herminia Yohko KANAMURA Sumie HOSHINO-SHIMIZU Regina Tomie KIMURA Tokiko Kyomen MATSUMOTO Luiz Caetano da SILVA Dirce Mary Correa LIMA Clarice Pires ABRANTES-LEMOS |
author_sort |
Herminia Yohko KANAMURA |
title |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_short |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_full |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_fullStr |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_full_unstemmed |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_sort |
decay of antibody isotypes against early developmental stages of schistosoma mansoni after treatment of schistosomiasis patients |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1997 |
url |
https://doi.org/10.1590/S0036-46651997000500005 https://doaj.org/article/3574f2feed3449fba2c3d325ae3bd57e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 5, p 271 (1997) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000500005 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651997000500005 0036-4665 1678-9946 https://doaj.org/article/3574f2feed3449fba2c3d325ae3bd57e |
op_doi |
https://doi.org/10.1590/S0036-46651997000500005 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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39 |
container_issue |
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271 |
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