High genetic diversity of Echinococcus canadensis G10 in northeastern Asia: is it the region of origin?

Echinococcus canadensis consists of 4 genotypes: G6, G7, G8 and G10. While the first 2 predominantly infect domestic animals, the latter are sylvatic in nature involving mainly wolves and cervids as hosts and can be found in the northern temperate to Arctic latitudes. This circumstance makes the acq...

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Bibliographic Details
Published in:Parasitology
Main Authors: Marion Wassermann, Francis Addy, Ludmila Kokolova, Innokentiy Okhlopkov, Sarah Leibrock, Jenny Oberle, Antti Oksanen, Thomas Romig
Format: Article in Journal/Newspaper
Language:English
Published: Cambridge University Press 2024
Subjects:
eastern Russia
Echinococcus canadensis G10
Echinococcus multilocularis
high genetic diversity of G10
Biochemistry
QD415-436
Infectious and parasitic diseases
RC109-216
Microbiology
QR1-502
Republic of Sakha
Alaska
Online Access:https://doi.org/10.1017/S0031182023001191
https://doaj.org/article/356a3969a7054ad1a9b62360bab59a13
Description
Summary:Echinococcus canadensis consists of 4 genotypes: G6, G7, G8 and G10. While the first 2 predominantly infect domestic animals, the latter are sylvatic in nature involving mainly wolves and cervids as hosts and can be found in the northern temperate to Arctic latitudes. This circumstance makes the acquisition of sample material difficult, and little information is known about their genetic structure. The majority of specimens analysed to date have been from the European region, comparatively few from northeast Asia and Alaska. In the current study, Echinococcus spp. from wolves and intermediate hosts from the Republic of Sakha in eastern Russia were examined. Echinococcus canadensis G10 was identified in 15 wolves and 4 cervid intermediate hosts. Complete mitochondrial cytochrome c oxidase subunit 1 (cox1) sequences were obtained from 42 worm and cyst specimens from Sakha and, for comparison, from an additional 13 G10 cysts from Finland. For comparative analyses of the genetic diversity of G10 of European and Asian origin, all available cox1 sequences from GenBank were included, increasing the number of sequences to 99. The diversity found in northeast Asia was by far higher than in Europe, suggesting that the geographic origin of E. canadensis (at least of G10) might be northeast Asia.

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