ABO System: molecular mimicry of Ascaris lumbricoides
A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients. 28 adult parasites were obtained from children to be used as assay material. The patients ABO blood groups were determined....
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:353bcb811c64458ebba66d4f179e0627 2024-09-09T19:26:48+00:00 ABO System: molecular mimicry of Ascaris lumbricoides Ponce de León Patricia Valverde Juana 2003-01-01T00:00:00Z https://doaj.org/article/353bcb811c64458ebba66d4f179e0627 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652003000200011 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/353bcb811c64458ebba66d4f179e0627 Revista do Instituto de Medicina Tropical de São Paulo, Vol 45, Iss 2, Pp 107-108 (2003) Ascaris lumbricoides ABO System Mimicry Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2003 ftdoajarticles 2024-08-05T17:49:30Z A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients. 28 adult parasites were obtained from children to be used as assay material. The patients ABO blood groups were determined. Extracts of A. lumbricoides [AE] were prepared by surgical remotion of the cuticle and refrigerated mechanical rupture. Agglutination Inhibition (AI) and Hemoagglutination Kinetics (HK) tests were used with the [AE]. Of the 28 [AE], eight belonged to O group patients, 15 to A group, three to B group and the remaining two to AB children. The AI Test showed A epitopes in two [AE] of group A patients and B epitopes in two [AE] of group B patients. The HK Test showed B antigenic determiners in two [AE] of group B patients and in two [AE] of group AB patients as well as A antigenic determiners in one [AE] of A group patient. Of the 28 [AE] studied in both tests B epitopes were detected in all [AE] from B and AB patients and A epitopes in three of the 15 [AE] of group A patients. The experiments carried out suggest that A. lumbricoides might absorb A and B antigens from the host, and/or modify the cuticular carbohydrates expression as a kind of antigenic mimicry. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
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collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Ascaris lumbricoides ABO System Mimicry Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Ascaris lumbricoides ABO System Mimicry Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ponce de León Patricia Valverde Juana ABO System: molecular mimicry of Ascaris lumbricoides |
topic_facet |
Ascaris lumbricoides ABO System Mimicry Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients. 28 adult parasites were obtained from children to be used as assay material. The patients ABO blood groups were determined. Extracts of A. lumbricoides [AE] were prepared by surgical remotion of the cuticle and refrigerated mechanical rupture. Agglutination Inhibition (AI) and Hemoagglutination Kinetics (HK) tests were used with the [AE]. Of the 28 [AE], eight belonged to O group patients, 15 to A group, three to B group and the remaining two to AB children. The AI Test showed A epitopes in two [AE] of group A patients and B epitopes in two [AE] of group B patients. The HK Test showed B antigenic determiners in two [AE] of group B patients and in two [AE] of group AB patients as well as A antigenic determiners in one [AE] of A group patient. Of the 28 [AE] studied in both tests B epitopes were detected in all [AE] from B and AB patients and A epitopes in three of the 15 [AE] of group A patients. The experiments carried out suggest that A. lumbricoides might absorb A and B antigens from the host, and/or modify the cuticular carbohydrates expression as a kind of antigenic mimicry. |
format |
Article in Journal/Newspaper |
author |
Ponce de León Patricia Valverde Juana |
author_facet |
Ponce de León Patricia Valverde Juana |
author_sort |
Ponce de León Patricia |
title |
ABO System: molecular mimicry of Ascaris lumbricoides |
title_short |
ABO System: molecular mimicry of Ascaris lumbricoides |
title_full |
ABO System: molecular mimicry of Ascaris lumbricoides |
title_fullStr |
ABO System: molecular mimicry of Ascaris lumbricoides |
title_full_unstemmed |
ABO System: molecular mimicry of Ascaris lumbricoides |
title_sort |
abo system: molecular mimicry of ascaris lumbricoides |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2003 |
url |
https://doaj.org/article/353bcb811c64458ebba66d4f179e0627 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 45, Iss 2, Pp 107-108 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652003000200011 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/353bcb811c64458ebba66d4f179e0627 |
_version_ |
1809896359858274304 |