Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia
Objective: To isolate and characterize the bioactive secondary metabolites from aerial parts of widespread Chenopodiaceae taxa growing in Saudi Arabia: Salsola villosa Delile. ex Schul. Methods: Antibacterial activities of chloroformic extract, fractions and isolate compounds was evaluated against f...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2015
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Online Access: | https://doi.org/10.1016/j.apjtb.2015.05.012 https://doaj.org/article/34a7bf5122d44cb5b9cd857e44c3e38d |
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ftdoajarticles:oai:doaj.org/article:34a7bf5122d44cb5b9cd857e44c3e38d 2023-05-15T15:13:43+02:00 Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia Mohamed Habib Oueslati Faraj A. Al-Ghamdi Adel Noubigh 2015-08-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.05.012 https://doaj.org/article/34a7bf5122d44cb5b9cd857e44c3e38d EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115001100 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.05.012 https://doaj.org/article/34a7bf5122d44cb5b9cd857e44c3e38d Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 8, Pp 624-628 (2015) Salsola villosa Salsolanol Biphenylsalsinol Spectroscopic analysis Antimicrobial activities Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.05.012 2022-12-31T03:10:55Z Objective: To isolate and characterize the bioactive secondary metabolites from aerial parts of widespread Chenopodiaceae taxa growing in Saudi Arabia: Salsola villosa Delile. ex Schul. Methods: Antibacterial activities of chloroformic extract, fractions and isolate compounds was evaluated against five bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus aureus and Staphylococcus epidermidis), using a paper disc diffusion method. The purification of compound(s) of chloroform extract was done by chromatographic column of silica gel. The structure elucidation was determined by extensive spectroscopic analysis (1H and 13C nuclear magnetic resonance, correlation spectroscopy, heteronuclear multiple bond correlation, heteronuclear multiple quantum coherence and nuclear overhauser enhancement spectroscopy) and high resolution electrospray ionization mass spectroscopy analysis. Results: Bioactivity guided fractionation of the chloroformic extract led to the isolation of two bioactive compounds: 4-(4′-hydroxy-2′-methylcyclopent-2′-enyloxy)-4-methylcyclopent-2-enol (1) named salsolanol and 4′-[3-(hydroxymethyl)oxiran-2-yl]-3-[(E)-3-hydroxyprop-1-en-1-yl]-6, 2′-dimethoxy [1, 1′-biphenyl]-2-ol (2) named biphenylsalsinol. The antibacterial effects of the chloroform extracts, fractions and isolated compounds 1 and 2 were also evaluated in this work. Results showed that the compounds 1 and 2 exhibited antibacterial activities against four strains: Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa with diameter of zone of inhibition ranging between (9.33 ± 0.94) to (26.33 ± 0.94) mm. Conclusions: Based on data presented here, two new natural compounds secondary cyclic alcohol 1 and biphenylpropanoid 2 isolated from bioactive chloroformic extract from aerial parts of Salsola villosa can be responsible for its antibacterial activities. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 8 624 628 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Salsola villosa Salsolanol Biphenylsalsinol Spectroscopic analysis Antimicrobial activities Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Salsola villosa Salsolanol Biphenylsalsinol Spectroscopic analysis Antimicrobial activities Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Mohamed Habib Oueslati Faraj A. Al-Ghamdi Adel Noubigh Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia |
topic_facet |
Salsola villosa Salsolanol Biphenylsalsinol Spectroscopic analysis Antimicrobial activities Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To isolate and characterize the bioactive secondary metabolites from aerial parts of widespread Chenopodiaceae taxa growing in Saudi Arabia: Salsola villosa Delile. ex Schul. Methods: Antibacterial activities of chloroformic extract, fractions and isolate compounds was evaluated against five bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus aureus and Staphylococcus epidermidis), using a paper disc diffusion method. The purification of compound(s) of chloroform extract was done by chromatographic column of silica gel. The structure elucidation was determined by extensive spectroscopic analysis (1H and 13C nuclear magnetic resonance, correlation spectroscopy, heteronuclear multiple bond correlation, heteronuclear multiple quantum coherence and nuclear overhauser enhancement spectroscopy) and high resolution electrospray ionization mass spectroscopy analysis. Results: Bioactivity guided fractionation of the chloroformic extract led to the isolation of two bioactive compounds: 4-(4′-hydroxy-2′-methylcyclopent-2′-enyloxy)-4-methylcyclopent-2-enol (1) named salsolanol and 4′-[3-(hydroxymethyl)oxiran-2-yl]-3-[(E)-3-hydroxyprop-1-en-1-yl]-6, 2′-dimethoxy [1, 1′-biphenyl]-2-ol (2) named biphenylsalsinol. The antibacterial effects of the chloroform extracts, fractions and isolated compounds 1 and 2 were also evaluated in this work. Results showed that the compounds 1 and 2 exhibited antibacterial activities against four strains: Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa with diameter of zone of inhibition ranging between (9.33 ± 0.94) to (26.33 ± 0.94) mm. Conclusions: Based on data presented here, two new natural compounds secondary cyclic alcohol 1 and biphenylpropanoid 2 isolated from bioactive chloroformic extract from aerial parts of Salsola villosa can be responsible for its antibacterial activities. |
format |
Article in Journal/Newspaper |
author |
Mohamed Habib Oueslati Faraj A. Al-Ghamdi Adel Noubigh |
author_facet |
Mohamed Habib Oueslati Faraj A. Al-Ghamdi Adel Noubigh |
author_sort |
Mohamed Habib Oueslati |
title |
Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia |
title_short |
Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia |
title_full |
Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia |
title_fullStr |
Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia |
title_full_unstemmed |
Two new bioactive salsolanol and biphenylsalsinol from the aerial parts of Salsola villosa Delile. ex Schul. (Chenopodiaceae) growing in Saudi Arabia |
title_sort |
two new bioactive salsolanol and biphenylsalsinol from the aerial parts of salsola villosa delile. ex schul. (chenopodiaceae) growing in saudi arabia |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.apjtb.2015.05.012 https://doaj.org/article/34a7bf5122d44cb5b9cd857e44c3e38d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 8, Pp 624-628 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115001100 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.05.012 https://doaj.org/article/34a7bf5122d44cb5b9cd857e44c3e38d |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.05.012 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
8 |
container_start_page |
624 |
op_container_end_page |
628 |
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1766344250186792960 |