Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise.
BACKGROUND:The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. METHODOLOGY/PRINCIPAL FINDINGS:We report a case of a 20-year-old pregnant woman who was referred to ou...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0004517 https://doaj.org/article/34a3cc564dbb44f4bdd27367e8ed87dc |
id |
ftdoajarticles:oai:doaj.org/article:34a3cc564dbb44f4bdd27367e8ed87dc |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:34a3cc564dbb44f4bdd27367e8ed87dc 2023-05-15T15:08:18+02:00 Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. Manoel Sarno Gielson A Sacramento Ricardo Khouri Mateus S do Rosário Federico Costa Gracinda Archanjo Luciane A Santos Nivison Nery Nikos Vasilakis Albert I Ko Antonio R P de Almeida 2016-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004517 https://doaj.org/article/34a3cc564dbb44f4bdd27367e8ed87dc EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4767410?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004517 https://doaj.org/article/34a3cc564dbb44f4bdd27367e8ed87dc PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004517 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004517 2022-12-31T15:58:41Z BACKGROUND:The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. METHODOLOGY/PRINCIPAL FINDINGS:We report a case of a 20-year-old pregnant woman who was referred to our service after a large Zika virus outbreak in the city of Salvador, Brazil with an ultrasound examination that showed intrauterine growth retardation of the fetus at the 18th gestational week. Ultrasound examinations in the 2nd and 3rd trimesters demonstrated severe microcephaly, hydranencephaly, intracranial calcifications and destructive lesions of posterior fossa, in addition to hydrothorax, ascites and subcutaneous edema. An induced labor was performed at the 32nd gestational week due to fetal demise and delivered a female fetus. ZIKV-specific real-time polymerase chain reaction amplification products were obtained from extracts of cerebral cortex, medulla oblongata and cerebrospinal and amniotic fluid, while extracts of heart, lung, liver, vitreous body of the eye and placenta did not yield detectable products. CONCLUSIONS/SIGNIFICANCE:This case report provides evidence that in addition to microcephaly, there may be a link between Zika virus infection and hydrops fetalis and fetal demise. Given the recent spread of the virus, systematic investigation of spontaneous abortions and stillbirths may be warranted to evaluate the risk that ZIKV infection imparts on these outcomes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Fossa ENVELOPE(9.795,9.795,62.990,62.990) PLOS Neglected Tropical Diseases 10 2 e0004517 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Manoel Sarno Gielson A Sacramento Ricardo Khouri Mateus S do Rosário Federico Costa Gracinda Archanjo Luciane A Santos Nivison Nery Nikos Vasilakis Albert I Ko Antonio R P de Almeida Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. METHODOLOGY/PRINCIPAL FINDINGS:We report a case of a 20-year-old pregnant woman who was referred to our service after a large Zika virus outbreak in the city of Salvador, Brazil with an ultrasound examination that showed intrauterine growth retardation of the fetus at the 18th gestational week. Ultrasound examinations in the 2nd and 3rd trimesters demonstrated severe microcephaly, hydranencephaly, intracranial calcifications and destructive lesions of posterior fossa, in addition to hydrothorax, ascites and subcutaneous edema. An induced labor was performed at the 32nd gestational week due to fetal demise and delivered a female fetus. ZIKV-specific real-time polymerase chain reaction amplification products were obtained from extracts of cerebral cortex, medulla oblongata and cerebrospinal and amniotic fluid, while extracts of heart, lung, liver, vitreous body of the eye and placenta did not yield detectable products. CONCLUSIONS/SIGNIFICANCE:This case report provides evidence that in addition to microcephaly, there may be a link between Zika virus infection and hydrops fetalis and fetal demise. Given the recent spread of the virus, systematic investigation of spontaneous abortions and stillbirths may be warranted to evaluate the risk that ZIKV infection imparts on these outcomes. |
format |
Article in Journal/Newspaper |
author |
Manoel Sarno Gielson A Sacramento Ricardo Khouri Mateus S do Rosário Federico Costa Gracinda Archanjo Luciane A Santos Nivison Nery Nikos Vasilakis Albert I Ko Antonio R P de Almeida |
author_facet |
Manoel Sarno Gielson A Sacramento Ricardo Khouri Mateus S do Rosário Federico Costa Gracinda Archanjo Luciane A Santos Nivison Nery Nikos Vasilakis Albert I Ko Antonio R P de Almeida |
author_sort |
Manoel Sarno |
title |
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. |
title_short |
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. |
title_full |
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. |
title_fullStr |
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. |
title_full_unstemmed |
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. |
title_sort |
zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004517 https://doaj.org/article/34a3cc564dbb44f4bdd27367e8ed87dc |
long_lat |
ENVELOPE(9.795,9.795,62.990,62.990) |
geographic |
Arctic Fossa |
geographic_facet |
Arctic Fossa |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004517 (2016) |
op_relation |
http://europepmc.org/articles/PMC4767410?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004517 https://doaj.org/article/34a3cc564dbb44f4bdd27367e8ed87dc |
op_doi |
https://doi.org/10.1371/journal.pntd.0004517 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
2 |
container_start_page |
e0004517 |
_version_ |
1766339684783357952 |