Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis?
Background: The incidence of tuberculosis (TB) disease in Greenland doubled in the 1990s. To combat the increase, national TB interventions were initiated in 2000 and strengthened in 2007. Objective: To determine whether the effect of interventions could be detected, we estimated the TB disease risk...
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ftdoajarticles:oai:doaj.org/article:34a15564ec7147f19de470a4a5c2c1e2 2023-05-15T15:10:13+02:00 Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis? Emilie Birch Mikael Andersson Anders Koch Flemming Stenz Bolette Søborg 2014-07-01T00:00:00Z https://doi.org/10.3402/ijch.v73.24843 https://doaj.org/article/34a15564ec7147f19de470a4a5c2c1e2 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/24843/pdf_1 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v73.24843 https://doaj.org/article/34a15564ec7147f19de470a4a5c2c1e2 International Journal of Circumpolar Health, Vol 73, Iss 0, Pp 1-5 (2014) epidemiological study tuberculosis disease tuberculosis control children Greenland Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.3402/ijch.v73.24843 2022-12-31T12:29:58Z Background: The incidence of tuberculosis (TB) disease in Greenland doubled in the 1990s. To combat the increase, national TB interventions were initiated in 2000 and strengthened in 2007. Objective: To determine whether the effect of interventions could be detected, we estimated the TB disease risk among children≤15 years before and after interventions were implemented. Design: For a study cohort, we recruited all children ≤15 years of age included in the Greenlandic Civil Registration System (CRS) from 1990 to 2010. The CRS identifier was used to link cohort participants with TB cases identified based on the Greenlandic National TB registry. Bacille Calmette Guerin (BCG) vaccination status was identified through year of birth, as BCG was offered to newborns born either before 1991 or after 1996. Years with interventions were defined as 2000–2006 (primary interventions) and 2007–2010 (intensified interventions). Risk of TB was estimated using Poisson regression. Results: The study included 35,858 children, of whom 209 had TB disease. The TB disease incidence decreased after interventions were implemented (2007–2010: IRR [incidence rate ratios] 0.62, 95% CI: 0.39–0.95, p=0.03, compared with the 1995–1999 period). The TB disease risk was inversely associated with BCG vaccination (IRR: 0.54, 95% CI: 0.41–0.72, p<0.001). Conclusions: Years with national TB interventions in Greenland, including neonate BCG vaccination, are associated with a lower TB disease incidence among children ≤15 years of age. Article in Journal/Newspaper Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health Directory of Open Access Journals: DOAJ Articles Arctic Greenland Calmette ENVELOPE(-67.150,-67.150,-68.050,-68.050) International Journal of Circumpolar Health 73 1 24843 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
epidemiological study tuberculosis disease tuberculosis control children Greenland Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
epidemiological study tuberculosis disease tuberculosis control children Greenland Arctic medicine. Tropical medicine RC955-962 Emilie Birch Mikael Andersson Anders Koch Flemming Stenz Bolette Søborg Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis? |
topic_facet |
epidemiological study tuberculosis disease tuberculosis control children Greenland Arctic medicine. Tropical medicine RC955-962 |
description |
Background: The incidence of tuberculosis (TB) disease in Greenland doubled in the 1990s. To combat the increase, national TB interventions were initiated in 2000 and strengthened in 2007. Objective: To determine whether the effect of interventions could be detected, we estimated the TB disease risk among children≤15 years before and after interventions were implemented. Design: For a study cohort, we recruited all children ≤15 years of age included in the Greenlandic Civil Registration System (CRS) from 1990 to 2010. The CRS identifier was used to link cohort participants with TB cases identified based on the Greenlandic National TB registry. Bacille Calmette Guerin (BCG) vaccination status was identified through year of birth, as BCG was offered to newborns born either before 1991 or after 1996. Years with interventions were defined as 2000–2006 (primary interventions) and 2007–2010 (intensified interventions). Risk of TB was estimated using Poisson regression. Results: The study included 35,858 children, of whom 209 had TB disease. The TB disease incidence decreased after interventions were implemented (2007–2010: IRR [incidence rate ratios] 0.62, 95% CI: 0.39–0.95, p=0.03, compared with the 1995–1999 period). The TB disease risk was inversely associated with BCG vaccination (IRR: 0.54, 95% CI: 0.41–0.72, p<0.001). Conclusions: Years with national TB interventions in Greenland, including neonate BCG vaccination, are associated with a lower TB disease incidence among children ≤15 years of age. |
format |
Article in Journal/Newspaper |
author |
Emilie Birch Mikael Andersson Anders Koch Flemming Stenz Bolette Søborg |
author_facet |
Emilie Birch Mikael Andersson Anders Koch Flemming Stenz Bolette Søborg |
author_sort |
Emilie Birch |
title |
Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis? |
title_short |
Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis? |
title_full |
Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis? |
title_fullStr |
Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis? |
title_full_unstemmed |
Ten years of tuberculosis intervention in Greenland – has it prevented cases of childhood tuberculosis? |
title_sort |
ten years of tuberculosis intervention in greenland – has it prevented cases of childhood tuberculosis? |
publisher |
Taylor & Francis Group |
publishDate |
2014 |
url |
https://doi.org/10.3402/ijch.v73.24843 https://doaj.org/article/34a15564ec7147f19de470a4a5c2c1e2 |
long_lat |
ENVELOPE(-67.150,-67.150,-68.050,-68.050) |
geographic |
Arctic Greenland Calmette |
geographic_facet |
Arctic Greenland Calmette |
genre |
Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health |
genre_facet |
Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health |
op_source |
International Journal of Circumpolar Health, Vol 73, Iss 0, Pp 1-5 (2014) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/24843/pdf_1 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v73.24843 https://doaj.org/article/34a15564ec7147f19de470a4a5c2c1e2 |
op_doi |
https://doi.org/10.3402/ijch.v73.24843 |
container_title |
International Journal of Circumpolar Health |
container_volume |
73 |
container_issue |
1 |
container_start_page |
24843 |
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1766341255118192640 |