Hookworm-related anaemia among pregnant women: a systematic review.
Hookworm infection is among the major causes of anaemia in poor communities, but its importance in causing maternal anaemia is poorly understood, and this has hampered effective lobbying for the inclusion of anthelmintic treatment in maternal health packages. We sought to review existing evidence on...
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ftdoajarticles:oai:doaj.org/article:344b949120744fef878a96eb437a3aaa 2023-05-15T15:16:17+02:00 Hookworm-related anaemia among pregnant women: a systematic review. Simon Brooker Peter J Hotez Donald A P Bundy 2008-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000291 https://doaj.org/article/344b949120744fef878a96eb437a3aaa EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2553481?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000291 https://doaj.org/article/344b949120744fef878a96eb437a3aaa PLoS Neglected Tropical Diseases, Vol 2, Iss 9, p e291 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000291 2022-12-31T09:26:49Z Hookworm infection is among the major causes of anaemia in poor communities, but its importance in causing maternal anaemia is poorly understood, and this has hampered effective lobbying for the inclusion of anthelmintic treatment in maternal health packages. We sought to review existing evidence on the role of hookworm as a risk factor for anaemia among pregnant women. We also estimate the number of hookworm infections in pregnant women in sub-Saharan Africa (SSA).Structured searches using MEDLINE and EMBASE as well as manual searches of reference lists were conducted, and unpublished data were obtained by contacting authors. Papers were independently reviewed by two authors, and relevant data were extracted. We compared haemoglobin concentration (Hb) according to intensity of hookworm infection and calculated standardised mean differences and 95% confidence intervals. To estimate the number of pregnant women, we used population surfaces and a spatial model of hookworm prevalence.One hundred and five reports were screened and 19 were eligible for inclusion: 13 cross-sectional studies, 2 randomised controlled trials, 2 non-randomised treatment trials and 2 observational studies. Comparing uninfected women and women lightly (1-1,999 eggs/gram [epg]) infected with hookworm, the standardised mean difference (SMD) was -0.24 (95% CI: -0.36 to -0.13). The SMD between women heavily (4000+ epg) infected and those lightly infected was -0.57 (95% CI: -0.87 to -0.26). All identified intervention studies showed a benefit of deworming for maternal or child health, but since a variety of outcomes measures were employed, quantitative evaluation was not possible. We estimate that 37.7 million women of reproductive age in SSA are infected with hookworm in 2005 and that approximately 6.9 million pregnant women are infected.Evidence indicates that increasing hookworm infection intensity is associated with lower haemoglobin levels in pregnant women in poor countries. There are insufficient data to quantify the benefits of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 9 e291 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Simon Brooker Peter J Hotez Donald A P Bundy Hookworm-related anaemia among pregnant women: a systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Hookworm infection is among the major causes of anaemia in poor communities, but its importance in causing maternal anaemia is poorly understood, and this has hampered effective lobbying for the inclusion of anthelmintic treatment in maternal health packages. We sought to review existing evidence on the role of hookworm as a risk factor for anaemia among pregnant women. We also estimate the number of hookworm infections in pregnant women in sub-Saharan Africa (SSA).Structured searches using MEDLINE and EMBASE as well as manual searches of reference lists were conducted, and unpublished data were obtained by contacting authors. Papers were independently reviewed by two authors, and relevant data were extracted. We compared haemoglobin concentration (Hb) according to intensity of hookworm infection and calculated standardised mean differences and 95% confidence intervals. To estimate the number of pregnant women, we used population surfaces and a spatial model of hookworm prevalence.One hundred and five reports were screened and 19 were eligible for inclusion: 13 cross-sectional studies, 2 randomised controlled trials, 2 non-randomised treatment trials and 2 observational studies. Comparing uninfected women and women lightly (1-1,999 eggs/gram [epg]) infected with hookworm, the standardised mean difference (SMD) was -0.24 (95% CI: -0.36 to -0.13). The SMD between women heavily (4000+ epg) infected and those lightly infected was -0.57 (95% CI: -0.87 to -0.26). All identified intervention studies showed a benefit of deworming for maternal or child health, but since a variety of outcomes measures were employed, quantitative evaluation was not possible. We estimate that 37.7 million women of reproductive age in SSA are infected with hookworm in 2005 and that approximately 6.9 million pregnant women are infected.Evidence indicates that increasing hookworm infection intensity is associated with lower haemoglobin levels in pregnant women in poor countries. There are insufficient data to quantify the benefits of ... |
format |
Article in Journal/Newspaper |
author |
Simon Brooker Peter J Hotez Donald A P Bundy |
author_facet |
Simon Brooker Peter J Hotez Donald A P Bundy |
author_sort |
Simon Brooker |
title |
Hookworm-related anaemia among pregnant women: a systematic review. |
title_short |
Hookworm-related anaemia among pregnant women: a systematic review. |
title_full |
Hookworm-related anaemia among pregnant women: a systematic review. |
title_fullStr |
Hookworm-related anaemia among pregnant women: a systematic review. |
title_full_unstemmed |
Hookworm-related anaemia among pregnant women: a systematic review. |
title_sort |
hookworm-related anaemia among pregnant women: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000291 https://doaj.org/article/344b949120744fef878a96eb437a3aaa |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 9, p e291 (2008) |
op_relation |
http://europepmc.org/articles/PMC2553481?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000291 https://doaj.org/article/344b949120744fef878a96eb437a3aaa |
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https://doi.org/10.1371/journal.pntd.0000291 |
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PLoS Neglected Tropical Diseases |
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