Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study.
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the...
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ftdoajarticles:oai:doaj.org/article:34408a0ca43442e3a254a83ecbc59a1f 2023-05-15T17:44:54+02:00 Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0140478 https://doaj.org/article/34408a0ca43442e3a254a83ecbc59a1f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4619526?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0140478 https://doaj.org/article/34408a0ca43442e3a254a83ecbc59a1f PLoS ONE, Vol 10, Iss 10, p e0140478 (2015) Medicine R Science Q article 2015 ftdoajarticles https://doi.org/10.1371/journal.pone.0140478 2022-12-30T23:16:41Z Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH)D concentration in GWAS were also associated with plasma 25(OH)D in our study (p-trend <0.005). After taking into account the false discovery rate, these SNPs were not significantly associated with breast cancer risk, nor were any of the other SNPs or haplotypes in VDR, RXRA, and CYP24A1. We observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer. These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH)D with breast cancer risk, do not support an association between vitamin D and breast cancer risk. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles PLOS ONE 10 10 e0140478 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. |
topic_facet |
Medicine R Science Q |
description |
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH)D concentration in GWAS were also associated with plasma 25(OH)D in our study (p-trend <0.005). After taking into account the false discovery rate, these SNPs were not significantly associated with breast cancer risk, nor were any of the other SNPs or haplotypes in VDR, RXRA, and CYP24A1. We observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer. These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH)D with breast cancer risk, do not support an association between vitamin D and breast cancer risk. |
format |
Article in Journal/Newspaper |
author |
Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte |
author_facet |
Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte |
author_sort |
Tess V Clendenen |
title |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. |
title_short |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. |
title_full |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. |
title_fullStr |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. |
title_full_unstemmed |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. |
title_sort |
genetic polymorphisms in vitamin d metabolism and signaling genes and risk of breast cancer: a nested case-control study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pone.0140478 https://doaj.org/article/34408a0ca43442e3a254a83ecbc59a1f |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
PLoS ONE, Vol 10, Iss 10, p e0140478 (2015) |
op_relation |
http://europepmc.org/articles/PMC4619526?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0140478 https://doaj.org/article/34408a0ca43442e3a254a83ecbc59a1f |
op_doi |
https://doi.org/10.1371/journal.pone.0140478 |
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PLOS ONE |
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10 |
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10 |
container_start_page |
e0140478 |
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1766147192983126016 |