Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways

• Published in: Neurobiology of Pain
• Main Authors: Edwin N. Aroke, Pamela Jackson, Lingsong Meng, Zhiguang Huo, Demario S. Overstreet, Terence M. Penn, Tammie L. Quinn, Yenisel Cruz-Almeida, Burel R. Goodin
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2022
• Subjects: Racial pain disparities; RRBS; Pain mechanisms; Chronic low back pain; Non-specific chronic low back pain; DNA methylation; Neurosciences. Biological psychiatry. Neuropsychiatry; RC321-571; Browning; DML
• Online Access: https://doi.org/10.1016/j.ynpai.2022.100086; https://doaj.org/article/342e2d9c687a493281d205284a26e567

Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation (DNAm) play a role in racial disparities in cLBP. Purpose: T...