Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways
Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation (DNAm) play a role in racial disparities in cLBP. Purpose: T...
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ftdoajarticles:oai:doaj.org/article:342e2d9c687a493281d205284a26e567 2023-05-15T16:02:07+02:00 Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways Edwin N. Aroke Pamela Jackson Lingsong Meng Zhiguang Huo Demario S. Overstreet Terence M. Penn Tammie L. Quinn Yenisel Cruz-Almeida Burel R. Goodin 2022-01-01T00:00:00Z https://doi.org/10.1016/j.ynpai.2022.100086 https://doaj.org/article/342e2d9c687a493281d205284a26e567 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2452073X22000034 https://doaj.org/toc/2452-073X 2452-073X doi:10.1016/j.ynpai.2022.100086 https://doaj.org/article/342e2d9c687a493281d205284a26e567 Neurobiology of Pain, Vol 11, Iss , Pp 100086- (2022) Racial pain disparities RRBS Pain mechanisms Chronic low back pain Non-specific chronic low back pain DNA methylation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 article 2022 ftdoajarticles https://doi.org/10.1016/j.ynpai.2022.100086 2022-12-30T23:53:52Z Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation (DNAm) play a role in racial disparities in cLBP. Purpose: To determine the relationship between DNAm levels and racial group differences in adults with cLBP. Our study’s secondary purpose was to perform a race-stratified comparison of adults with cLBP and pain-free controls and identify functional genomic pathways enriched by annotated differentially methylated genes. Patients and Methods: We recruited 49 NHBs and 49 NHWs (49 cLBP and 49 pain-free controls, PFCs), analyzed DNAm from whole blood using reduced representation bisulfite sequencing, and identified enriched genomic pathways. Results: Among participants with cLBP, we identified 2873 differentially methylated loci (DML; methylation differences of at least 10% and p < 0.0001), many of which were annotated to genes of importance to pain pathology. These DMLs significantly enriched pathways to involved in nociception/pain processing (Dopamine-DARPP32 Feedback in cAMP signaling, GABA Receptor Signaling, Opioid Signaling) and neuronal differentiation (e.g., Calcium Signaling, Axon Guidance Signaling, and Endocannabinoid Neuronal Synapse). Our race stratified analyses of individuals with cLBP versus PFCs revealed 2356 DMLs in NHBs and 772 DMLs in NHWs with p < 0.0001 and > 10% methylation difference. Ingenuity Pathway Analysis revealed that many pathways of significance to pain such as Corticotropin Releasing Hormone Signaling, White Adipose Tissue Browning, and GABA Receptor Signaling pathways, were more significant in NHBs than NHWs. Conclusion: Even though an individual’s self-identified race is a social construct, not a biological variable, racism associated with that classification affects virtually every aspect of life, including disease risk. DNAm induced alterations in stress signaling pathways may explain ... Article in Journal/Newspaper DML Directory of Open Access Journals: DOAJ Articles Browning ENVELOPE(164.050,164.050,-74.617,-74.617) Neurobiology of Pain 11 100086 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Racial pain disparities RRBS Pain mechanisms Chronic low back pain Non-specific chronic low back pain DNA methylation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
spellingShingle |
Racial pain disparities RRBS Pain mechanisms Chronic low back pain Non-specific chronic low back pain DNA methylation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Edwin N. Aroke Pamela Jackson Lingsong Meng Zhiguang Huo Demario S. Overstreet Terence M. Penn Tammie L. Quinn Yenisel Cruz-Almeida Burel R. Goodin Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways |
topic_facet |
Racial pain disparities RRBS Pain mechanisms Chronic low back pain Non-specific chronic low back pain DNA methylation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
description |
Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation (DNAm) play a role in racial disparities in cLBP. Purpose: To determine the relationship between DNAm levels and racial group differences in adults with cLBP. Our study’s secondary purpose was to perform a race-stratified comparison of adults with cLBP and pain-free controls and identify functional genomic pathways enriched by annotated differentially methylated genes. Patients and Methods: We recruited 49 NHBs and 49 NHWs (49 cLBP and 49 pain-free controls, PFCs), analyzed DNAm from whole blood using reduced representation bisulfite sequencing, and identified enriched genomic pathways. Results: Among participants with cLBP, we identified 2873 differentially methylated loci (DML; methylation differences of at least 10% and p < 0.0001), many of which were annotated to genes of importance to pain pathology. These DMLs significantly enriched pathways to involved in nociception/pain processing (Dopamine-DARPP32 Feedback in cAMP signaling, GABA Receptor Signaling, Opioid Signaling) and neuronal differentiation (e.g., Calcium Signaling, Axon Guidance Signaling, and Endocannabinoid Neuronal Synapse). Our race stratified analyses of individuals with cLBP versus PFCs revealed 2356 DMLs in NHBs and 772 DMLs in NHWs with p < 0.0001 and > 10% methylation difference. Ingenuity Pathway Analysis revealed that many pathways of significance to pain such as Corticotropin Releasing Hormone Signaling, White Adipose Tissue Browning, and GABA Receptor Signaling pathways, were more significant in NHBs than NHWs. Conclusion: Even though an individual’s self-identified race is a social construct, not a biological variable, racism associated with that classification affects virtually every aspect of life, including disease risk. DNAm induced alterations in stress signaling pathways may explain ... |
format |
Article in Journal/Newspaper |
author |
Edwin N. Aroke Pamela Jackson Lingsong Meng Zhiguang Huo Demario S. Overstreet Terence M. Penn Tammie L. Quinn Yenisel Cruz-Almeida Burel R. Goodin |
author_facet |
Edwin N. Aroke Pamela Jackson Lingsong Meng Zhiguang Huo Demario S. Overstreet Terence M. Penn Tammie L. Quinn Yenisel Cruz-Almeida Burel R. Goodin |
author_sort |
Edwin N. Aroke |
title |
Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways |
title_short |
Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways |
title_full |
Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways |
title_fullStr |
Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways |
title_full_unstemmed |
Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways |
title_sort |
differential dna methylation in black and white individuals with chronic low back pain enrich different genomic pathways |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://doi.org/10.1016/j.ynpai.2022.100086 https://doaj.org/article/342e2d9c687a493281d205284a26e567 |
long_lat |
ENVELOPE(164.050,164.050,-74.617,-74.617) |
geographic |
Browning |
geographic_facet |
Browning |
genre |
DML |
genre_facet |
DML |
op_source |
Neurobiology of Pain, Vol 11, Iss , Pp 100086- (2022) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2452073X22000034 https://doaj.org/toc/2452-073X 2452-073X doi:10.1016/j.ynpai.2022.100086 https://doaj.org/article/342e2d9c687a493281d205284a26e567 |
op_doi |
https://doi.org/10.1016/j.ynpai.2022.100086 |
container_title |
Neurobiology of Pain |
container_volume |
11 |
container_start_page |
100086 |
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1766397724688646144 |