Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant Enterococcus faecalis

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Tiane Martin de Moura, Fabrício Souza Campos, Juliana Caierão, Ana Claudia Franco, Paulo Michel Roehe, Pedro Alves d'Azevedo, Jeverson Frazzon, Ana Paula Guedes Frazzon
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2015
• Subjects: VRE; Biofilm; Expression; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0017-2015; https://doaj.org/article/342d644441fd4df8bd82d91c59a7b527

ABSTRACTINTRODUCTION:Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome.METHODS: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin.RESULTS:A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro .CONCLUSIONS:Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.