Monitoring of chronic wasting disease (CWD) (IV)
Abstract The European Commission requested an analysis of the Chronic Wasting Disease (CWD) monitoring programme in Norway, Sweden, Finland, Iceland, Estonia, Latvia, Lithuania and Poland (9 January 2017–28 February 2022). Thirteen cases were detected in reindeer, 15 in moose and 3 in red deer. They...
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ftdoajarticles:oai:doaj.org/article:33e87a316df8450cb47628bc968ed96a 2023-08-20T04:07:33+02:00 Monitoring of chronic wasting disease (CWD) (IV) EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordoñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Luisa Peixe Panagiotis Skandamis Elisabetta Suffredini Michael W Miller Atle Mysterud Maria Nöremark Marion Simmons Michael A Tranulis Gabriele Vaccari Hildegunn Viljugrein Angel Ortiz‐Pelaez Giuseppe Ru 2023-04-01T00:00:00Z https://doi.org/10.2903/j.efsa.2023.7936 https://doaj.org/article/33e87a316df8450cb47628bc968ed96a EN eng Wiley https://doi.org/10.2903/j.efsa.2023.7936 https://doaj.org/toc/1831-4732 1831-4732 doi:10.2903/j.efsa.2023.7936 https://doaj.org/article/33e87a316df8450cb47628bc968ed96a EFSA Journal, Vol 21, Iss 4, Pp n/a-n/a (2023) chronic wasting CWD surveillance Europe genotype Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 article 2023 ftdoajarticles https://doi.org/10.2903/j.efsa.2023.7936 2023-07-30T00:39:30Z Abstract The European Commission requested an analysis of the Chronic Wasting Disease (CWD) monitoring programme in Norway, Sweden, Finland, Iceland, Estonia, Latvia, Lithuania and Poland (9 January 2017–28 February 2022). Thirteen cases were detected in reindeer, 15 in moose and 3 in red deer. They showed two phenotypes, distinguished by the presence or absence of detectable disease‐associated normal cellular prion protein (PrP) in lymphoreticular tissues. CWD was detected for the first time in Finland, Sweden and in other areas of Norway. In countries where the disease was not detected, the evidence was insufficient to rule out its presence altogether. Where cases were detected, the prevalence was below 1%. The data also suggest that the high‐risk target groups for surveillance should be revised, and ‘road kill’ removed. Data show that, in addition to differences in age and sex, there are differences in the prion protein gene (PRNP) genotypes between positive and negative wild reindeer. A stepwise framework has been proposed with expanded minimum background surveillance to be implemented in European countries with relevant cervid species. Additional surveillance may include ad hoc surveys for four different objectives, specific to countries with/without cases, focusing on parallel testing of obex and lymph nodes from adult cervids in high‐risk target groups, sustained over time, using sampling units and a data‐driven design prevalence. Criteria for assessing the probability of CWD presence have been outlined, based on the definition of the geographical area, an annual assessment of risk of introduction, sustained minimum background surveillance, training and engagement of stakeholders and a surveillance programme based on data‐driven parameters. All positive cases should be genotyped. Sample sizes for negative samples have been proposed to detect and estimate the frequency of PRNP polymorphisms. Double‐strand sequencing of the entire PRNP open reading frame should be undertaken for all selected samples, with ... Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles Norway EFSA Journal 21 4 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
chronic wasting CWD surveillance Europe genotype Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 |
spellingShingle |
chronic wasting CWD surveillance Europe genotype Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordoñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Luisa Peixe Panagiotis Skandamis Elisabetta Suffredini Michael W Miller Atle Mysterud Maria Nöremark Marion Simmons Michael A Tranulis Gabriele Vaccari Hildegunn Viljugrein Angel Ortiz‐Pelaez Giuseppe Ru Monitoring of chronic wasting disease (CWD) (IV) |
topic_facet |
chronic wasting CWD surveillance Europe genotype Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 |
description |
Abstract The European Commission requested an analysis of the Chronic Wasting Disease (CWD) monitoring programme in Norway, Sweden, Finland, Iceland, Estonia, Latvia, Lithuania and Poland (9 January 2017–28 February 2022). Thirteen cases were detected in reindeer, 15 in moose and 3 in red deer. They showed two phenotypes, distinguished by the presence or absence of detectable disease‐associated normal cellular prion protein (PrP) in lymphoreticular tissues. CWD was detected for the first time in Finland, Sweden and in other areas of Norway. In countries where the disease was not detected, the evidence was insufficient to rule out its presence altogether. Where cases were detected, the prevalence was below 1%. The data also suggest that the high‐risk target groups for surveillance should be revised, and ‘road kill’ removed. Data show that, in addition to differences in age and sex, there are differences in the prion protein gene (PRNP) genotypes between positive and negative wild reindeer. A stepwise framework has been proposed with expanded minimum background surveillance to be implemented in European countries with relevant cervid species. Additional surveillance may include ad hoc surveys for four different objectives, specific to countries with/without cases, focusing on parallel testing of obex and lymph nodes from adult cervids in high‐risk target groups, sustained over time, using sampling units and a data‐driven design prevalence. Criteria for assessing the probability of CWD presence have been outlined, based on the definition of the geographical area, an annual assessment of risk of introduction, sustained minimum background surveillance, training and engagement of stakeholders and a surveillance programme based on data‐driven parameters. All positive cases should be genotyped. Sample sizes for negative samples have been proposed to detect and estimate the frequency of PRNP polymorphisms. Double‐strand sequencing of the entire PRNP open reading frame should be undertaken for all selected samples, with ... |
format |
Article in Journal/Newspaper |
author |
EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordoñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Luisa Peixe Panagiotis Skandamis Elisabetta Suffredini Michael W Miller Atle Mysterud Maria Nöremark Marion Simmons Michael A Tranulis Gabriele Vaccari Hildegunn Viljugrein Angel Ortiz‐Pelaez Giuseppe Ru |
author_facet |
EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordoñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Luisa Peixe Panagiotis Skandamis Elisabetta Suffredini Michael W Miller Atle Mysterud Maria Nöremark Marion Simmons Michael A Tranulis Gabriele Vaccari Hildegunn Viljugrein Angel Ortiz‐Pelaez Giuseppe Ru |
author_sort |
EFSA Panel on Biological Hazards (BIOHAZ) |
title |
Monitoring of chronic wasting disease (CWD) (IV) |
title_short |
Monitoring of chronic wasting disease (CWD) (IV) |
title_full |
Monitoring of chronic wasting disease (CWD) (IV) |
title_fullStr |
Monitoring of chronic wasting disease (CWD) (IV) |
title_full_unstemmed |
Monitoring of chronic wasting disease (CWD) (IV) |
title_sort |
monitoring of chronic wasting disease (cwd) (iv) |
publisher |
Wiley |
publishDate |
2023 |
url |
https://doi.org/10.2903/j.efsa.2023.7936 https://doaj.org/article/33e87a316df8450cb47628bc968ed96a |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
EFSA Journal, Vol 21, Iss 4, Pp n/a-n/a (2023) |
op_relation |
https://doi.org/10.2903/j.efsa.2023.7936 https://doaj.org/toc/1831-4732 1831-4732 doi:10.2903/j.efsa.2023.7936 https://doaj.org/article/33e87a316df8450cb47628bc968ed96a |
op_doi |
https://doi.org/10.2903/j.efsa.2023.7936 |
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EFSA Journal |
container_volume |
21 |
container_issue |
4 |
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1774719253978546176 |