Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni
In this study, four compounds were utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1995
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Online Access: | https://doi.org/10.1590/S0037-86821995000300003 https://doaj.org/article/33dc8bf211e4434abef7c7c8bc4af2cb |
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ftdoajarticles:oai:doaj.org/article:33dc8bf211e4434abef7c7c8bc4af2cb 2023-05-15T15:04:30+02:00 Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni Paulo Marcos Zech Coelho Leógenes Horácio Pereira Rômulo Teixeira de Mello 1995-09-01T00:00:00Z https://doi.org/10.1590/S0037-86821995000300003 https://doaj.org/article/33dc8bf211e4434abef7c7c8bc4af2cb EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000300003&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821995000300003 https://doaj.org/article/33dc8bf211e4434abef7c7c8bc4af2cb Revista da Sociedade Brasileira de Medicina Tropical, Vol 28, Iss 3, Pp 179-183 (1995) Schistosoma mansoni Macacos Cebus Acridanona-hidrazonas Arctic medicine. Tropical medicine RC955-962 article 1995 ftdoajarticles https://doi.org/10.1590/S0037-86821995000300003 2022-12-30T23:10:48Z In this study, four compounds were utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanone- hydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these dmgs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamniquine and praziquantel. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 28 3 179 183 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Schistosoma mansoni Macacos Cebus Acridanona-hidrazonas Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Schistosoma mansoni Macacos Cebus Acridanona-hidrazonas Arctic medicine. Tropical medicine RC955-962 Paulo Marcos Zech Coelho Leógenes Horácio Pereira Rômulo Teixeira de Mello Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
topic_facet |
Schistosoma mansoni Macacos Cebus Acridanona-hidrazonas Arctic medicine. Tropical medicine RC955-962 |
description |
In this study, four compounds were utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanone- hydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these dmgs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamniquine and praziquantel. |
format |
Article in Journal/Newspaper |
author |
Paulo Marcos Zech Coelho Leógenes Horácio Pereira Rômulo Teixeira de Mello |
author_facet |
Paulo Marcos Zech Coelho Leógenes Horácio Pereira Rômulo Teixeira de Mello |
author_sort |
Paulo Marcos Zech Coelho |
title |
Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
title_short |
Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
title_full |
Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
title_fullStr |
Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
title_full_unstemmed |
Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
title_sort |
antischistosomal activity of acridanone- hydrazones in cebus monkeys experimentally infected with the sj strain of schistosoma mansoni |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1995 |
url |
https://doi.org/10.1590/S0037-86821995000300003 https://doaj.org/article/33dc8bf211e4434abef7c7c8bc4af2cb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 28, Iss 3, Pp 179-183 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000300003&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821995000300003 https://doaj.org/article/33dc8bf211e4434abef7c7c8bc4af2cb |
op_doi |
https://doi.org/10.1590/S0037-86821995000300003 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
28 |
container_issue |
3 |
container_start_page |
179 |
op_container_end_page |
183 |
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