The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa.
The extensive use of insecticides for vector control has led to the development of insecticide resistance in Aedes aegypti populations on a global scale, which has significantly compromised control actions. Insecticide resistance, and its underlying mechanisms, has been investigated in several count...
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ftdoajarticles:oai:doaj.org/article:33c89db6de4141fabdb772a0eea9c718 2023-05-15T15:08:08+02:00 The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa. Constância F J Ayres Gonçalo Seixas Sílvia Borrego Cátia Marques Inilça Monteiro Camila S Marques Bruna Gouveia Silvania Leal Arlete D Troco Filomeno Fortes Ricardo Parreira João Pinto Carla A Sousa 2020-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008216 https://doaj.org/article/33c89db6de4141fabdb772a0eea9c718 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008216 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008216 https://doaj.org/article/33c89db6de4141fabdb772a0eea9c718 PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008216 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008216 2022-12-31T05:48:41Z The extensive use of insecticides for vector control has led to the development of insecticide resistance in Aedes aegypti populations on a global scale, which has significantly compromised control actions. Insecticide resistance, and its underlying mechanisms, has been investigated in several countries, mostly in South American and Asian countries. In Africa, however, studies reporting insecticide resistance are rare and data on resistance mechanisms, notably knockdown resistance (kdr) mutations, is scarce. In this study, the recently described V410L kdr mutation is reported for the first time in old world Ae. aegypti populations, namely from Angola and Madeira island. Two additional kdr mutations, V1016I and F1534C, are also reported for the first time in populations from Angola and Cape Verde. Significant associations with the resistance phenotype were found for both V410L and V1016I individually as well as for tri-locus genotypes in the Angolan population. However, no association was found in Madeira island, probably due to the presence of a complex pattern of multiple insecticide resistance mechanisms in the local Ae. aegypti population. These results suggest that populations carrying the same kdr mutations may respond differently to the same insecticide, stressing the need for complementary studies when assessing the impact of kdr resistance mechanisms in the outcome of insecticide-based control strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 5 e0008216 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Constância F J Ayres Gonçalo Seixas Sílvia Borrego Cátia Marques Inilça Monteiro Camila S Marques Bruna Gouveia Silvania Leal Arlete D Troco Filomeno Fortes Ricardo Parreira João Pinto Carla A Sousa The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The extensive use of insecticides for vector control has led to the development of insecticide resistance in Aedes aegypti populations on a global scale, which has significantly compromised control actions. Insecticide resistance, and its underlying mechanisms, has been investigated in several countries, mostly in South American and Asian countries. In Africa, however, studies reporting insecticide resistance are rare and data on resistance mechanisms, notably knockdown resistance (kdr) mutations, is scarce. In this study, the recently described V410L kdr mutation is reported for the first time in old world Ae. aegypti populations, namely from Angola and Madeira island. Two additional kdr mutations, V1016I and F1534C, are also reported for the first time in populations from Angola and Cape Verde. Significant associations with the resistance phenotype were found for both V410L and V1016I individually as well as for tri-locus genotypes in the Angolan population. However, no association was found in Madeira island, probably due to the presence of a complex pattern of multiple insecticide resistance mechanisms in the local Ae. aegypti population. These results suggest that populations carrying the same kdr mutations may respond differently to the same insecticide, stressing the need for complementary studies when assessing the impact of kdr resistance mechanisms in the outcome of insecticide-based control strategies. |
format |
Article in Journal/Newspaper |
author |
Constância F J Ayres Gonçalo Seixas Sílvia Borrego Cátia Marques Inilça Monteiro Camila S Marques Bruna Gouveia Silvania Leal Arlete D Troco Filomeno Fortes Ricardo Parreira João Pinto Carla A Sousa |
author_facet |
Constância F J Ayres Gonçalo Seixas Sílvia Borrego Cátia Marques Inilça Monteiro Camila S Marques Bruna Gouveia Silvania Leal Arlete D Troco Filomeno Fortes Ricardo Parreira João Pinto Carla A Sousa |
author_sort |
Constância F J Ayres |
title |
The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa. |
title_short |
The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa. |
title_full |
The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa. |
title_fullStr |
The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa. |
title_full_unstemmed |
The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa. |
title_sort |
v410l knockdown resistance mutation occurs in island and continental populations of aedes aegypti in west and central africa. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008216 https://doaj.org/article/33c89db6de4141fabdb772a0eea9c718 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008216 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008216 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008216 https://doaj.org/article/33c89db6de4141fabdb772a0eea9c718 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008216 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
5 |
container_start_page |
e0008216 |
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1766339543293755392 |