FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS
The favorable outcome of the treatment of a disease is influenced by the adherence to therapy. Our objective was to assess factors associated with adherence to treatment of patients included in a clinical trial of equivalence between the standard and alternative treatment schemes with meglumine anti...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
2014
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Online Access: | https://doi.org/10.1590/S0036-46652014000400004 https://doaj.org/article/33bff2e66e194fbb962bed65a0a7cd01 |
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ftdoajarticles:oai:doaj.org/article:33bff2e66e194fbb962bed65a0a7cd01 2024-09-09T19:26:30+00:00 FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS Madelon Novato Ribeiro Maria Inês Fernandes Pimentel Armando de Oliveira Schubach Raquel de Vasconcellos Carvalhães de Oliveira José Liporage Teixeira Madson Pedro da Silva Leite Monique Fonseca Ginelza Peres Lima dos Santos Mariza Matos Salgueiro Erica de Camargo Ferreira e Vasconcellos Marcelo Rosandiski Lyra Mauricio Naoto Saheki Claudia Maria Valete-Rosalino 2014-07-01T00:00:00Z https://doi.org/10.1590/S0036-46652014000400004 https://doaj.org/article/33bff2e66e194fbb962bed65a0a7cd01 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000400291&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000400004 https://doaj.org/article/33bff2e66e194fbb962bed65a0a7cd01 Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 4, Pp 291-296 (2014) Cutaneous leishmaniasis Pentavalent antimonials Adherence Therapy Treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2014 ftdoajarticles https://doi.org/10.1590/S0036-46652014000400004 2024-08-05T17:49:30Z The favorable outcome of the treatment of a disease is influenced by the adherence to therapy. Our objective was to assess factors associated with adherence to treatment of patients included in a clinical trial of equivalence between the standard and alternative treatment schemes with meglumine antimoniate (MA) in the treatment of cutaneous leishmaniasis (CL), in the state of Rio de Janeiro. Between 2008 and 2011, 57 patients with CL were interviewed using a questionnaire to collect socioeconomic data. The following methods were used for adherence monitoring: counting of vial surplus, monitoring card, Morisky test and modified Morisky test (without the question regarding the schedule); we observed 82.1% (vial return), 86.0% (monitoring card), 66.7% (Morisky test) and 86.0% (modified Morisky test) adherence. There was a strong correlation between the method of vial counting and the monitoring card and modified Morisky test. A significant association was observed between greater adherence to treatment and low dose of MA, as well as with a lower number of people sleeping in the same room. We recommend the use of the modified Morisky test to assess adherence to treatment of CL with MA, because it is a simple method and with a good performance, when compared to other methods. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 56 4 291 296 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cutaneous leishmaniasis Pentavalent antimonials Adherence Therapy Treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Cutaneous leishmaniasis Pentavalent antimonials Adherence Therapy Treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Madelon Novato Ribeiro Maria Inês Fernandes Pimentel Armando de Oliveira Schubach Raquel de Vasconcellos Carvalhães de Oliveira José Liporage Teixeira Madson Pedro da Silva Leite Monique Fonseca Ginelza Peres Lima dos Santos Mariza Matos Salgueiro Erica de Camargo Ferreira e Vasconcellos Marcelo Rosandiski Lyra Mauricio Naoto Saheki Claudia Maria Valete-Rosalino FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS |
topic_facet |
Cutaneous leishmaniasis Pentavalent antimonials Adherence Therapy Treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
The favorable outcome of the treatment of a disease is influenced by the adherence to therapy. Our objective was to assess factors associated with adherence to treatment of patients included in a clinical trial of equivalence between the standard and alternative treatment schemes with meglumine antimoniate (MA) in the treatment of cutaneous leishmaniasis (CL), in the state of Rio de Janeiro. Between 2008 and 2011, 57 patients with CL were interviewed using a questionnaire to collect socioeconomic data. The following methods were used for adherence monitoring: counting of vial surplus, monitoring card, Morisky test and modified Morisky test (without the question regarding the schedule); we observed 82.1% (vial return), 86.0% (monitoring card), 66.7% (Morisky test) and 86.0% (modified Morisky test) adherence. There was a strong correlation between the method of vial counting and the monitoring card and modified Morisky test. A significant association was observed between greater adherence to treatment and low dose of MA, as well as with a lower number of people sleeping in the same room. We recommend the use of the modified Morisky test to assess adherence to treatment of CL with MA, because it is a simple method and with a good performance, when compared to other methods. |
format |
Article in Journal/Newspaper |
author |
Madelon Novato Ribeiro Maria Inês Fernandes Pimentel Armando de Oliveira Schubach Raquel de Vasconcellos Carvalhães de Oliveira José Liporage Teixeira Madson Pedro da Silva Leite Monique Fonseca Ginelza Peres Lima dos Santos Mariza Matos Salgueiro Erica de Camargo Ferreira e Vasconcellos Marcelo Rosandiski Lyra Mauricio Naoto Saheki Claudia Maria Valete-Rosalino |
author_facet |
Madelon Novato Ribeiro Maria Inês Fernandes Pimentel Armando de Oliveira Schubach Raquel de Vasconcellos Carvalhães de Oliveira José Liporage Teixeira Madson Pedro da Silva Leite Monique Fonseca Ginelza Peres Lima dos Santos Mariza Matos Salgueiro Erica de Camargo Ferreira e Vasconcellos Marcelo Rosandiski Lyra Mauricio Naoto Saheki Claudia Maria Valete-Rosalino |
author_sort |
Madelon Novato Ribeiro |
title |
FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS |
title_short |
FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS |
title_full |
FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS |
title_fullStr |
FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS |
title_full_unstemmed |
FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS |
title_sort |
factors associated to adherence to different treatment schemes with meglumine antimoniate in a clinical trial for cutaneous leishmaniasis |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2014 |
url |
https://doi.org/10.1590/S0036-46652014000400004 https://doaj.org/article/33bff2e66e194fbb962bed65a0a7cd01 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 4, Pp 291-296 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000400291&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000400004 https://doaj.org/article/33bff2e66e194fbb962bed65a0a7cd01 |
op_doi |
https://doi.org/10.1590/S0036-46652014000400004 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
56 |
container_issue |
4 |
container_start_page |
291 |
op_container_end_page |
296 |
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1809896097830666240 |