Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09.
OBJECTIVE: Enterovirus 71 (EV71) is causing life-threatening outbreaks in tropical Asia. In Taiwan and other tropical Asian countries, although nationwide EV71 epidemics occur cyclically, age-specific incidence rates of EV71 infections that are critical to estimate disease burden and design vaccine...
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ftdoajarticles:oai:doaj.org/article:33b287e44820486d83f59d48f1b7e203 2023-05-15T15:09:57+02:00 Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09. Min-Shi Lee Pai-Shan Chiang Shu-Ting Luo Mei-Liang Huang Guan-Yuan Liou Kuo-Chien Tsao Tzou-Yien Lin 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001476 https://doaj.org/article/33b287e44820486d83f59d48f1b7e203 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3279337?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001476 https://doaj.org/article/33b287e44820486d83f59d48f1b7e203 PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1476 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001476 2022-12-31T07:25:13Z OBJECTIVE: Enterovirus 71 (EV71) is causing life-threatening outbreaks in tropical Asia. In Taiwan and other tropical Asian countries, although nationwide EV71 epidemics occur cyclically, age-specific incidence rates of EV71 infections that are critical to estimate disease burden and design vaccine trials are not clear. A nationwide EV71 epidemic occurred in 2008-09 in Taiwan, which provided a unique opportunity to estimate age-specific incidence rates of EV71 infections. STUDY DESIGN: We prospectively recruited 749 healthy neonates and conducted follow-ups from June 2006 to December 2009. Sera were obtained from participants at 0, 6, 12, 24, and 36 months of age for measuring EV71 neutralizing antibody titers. If the participants developed suspected enterovirus illnesses, throat swabs were collected for virus isolation. RESULTS: We detected 28 EV71 infections including 20 symptomatic and 8 asymptomatic infections. Age-specific incidence rates of EV71 infection increased from 1.71 per 100 person-years at 0-6 months of age to 4.09, 5.74, and 4.97 per 100 person-years at 7-12, 13-24, and 25-36 months of age, respectively. Cumulative incidence rate was 15.15 per 100 persons by 36 months of age, respectively. CONCLUSIONS: Risk of EV71 infections in Taiwan increased after 6 months of age during EV71 epidemics. The cumulative incidence rate was 15% by 36 months of age, and 29% of EV71 infections were asymptomatic in young children. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 2 e1476 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Min-Shi Lee Pai-Shan Chiang Shu-Ting Luo Mei-Liang Huang Guan-Yuan Liou Kuo-Chien Tsao Tzou-Yien Lin Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: Enterovirus 71 (EV71) is causing life-threatening outbreaks in tropical Asia. In Taiwan and other tropical Asian countries, although nationwide EV71 epidemics occur cyclically, age-specific incidence rates of EV71 infections that are critical to estimate disease burden and design vaccine trials are not clear. A nationwide EV71 epidemic occurred in 2008-09 in Taiwan, which provided a unique opportunity to estimate age-specific incidence rates of EV71 infections. STUDY DESIGN: We prospectively recruited 749 healthy neonates and conducted follow-ups from June 2006 to December 2009. Sera were obtained from participants at 0, 6, 12, 24, and 36 months of age for measuring EV71 neutralizing antibody titers. If the participants developed suspected enterovirus illnesses, throat swabs were collected for virus isolation. RESULTS: We detected 28 EV71 infections including 20 symptomatic and 8 asymptomatic infections. Age-specific incidence rates of EV71 infection increased from 1.71 per 100 person-years at 0-6 months of age to 4.09, 5.74, and 4.97 per 100 person-years at 7-12, 13-24, and 25-36 months of age, respectively. Cumulative incidence rate was 15.15 per 100 persons by 36 months of age, respectively. CONCLUSIONS: Risk of EV71 infections in Taiwan increased after 6 months of age during EV71 epidemics. The cumulative incidence rate was 15% by 36 months of age, and 29% of EV71 infections were asymptomatic in young children. |
format |
Article in Journal/Newspaper |
author |
Min-Shi Lee Pai-Shan Chiang Shu-Ting Luo Mei-Liang Huang Guan-Yuan Liou Kuo-Chien Tsao Tzou-Yien Lin |
author_facet |
Min-Shi Lee Pai-Shan Chiang Shu-Ting Luo Mei-Liang Huang Guan-Yuan Liou Kuo-Chien Tsao Tzou-Yien Lin |
author_sort |
Min-Shi Lee |
title |
Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09. |
title_short |
Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09. |
title_full |
Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09. |
title_fullStr |
Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09. |
title_full_unstemmed |
Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008-09. |
title_sort |
incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in taiwan, 2008-09. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001476 https://doaj.org/article/33b287e44820486d83f59d48f1b7e203 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1476 (2012) |
op_relation |
http://europepmc.org/articles/PMC3279337?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001476 https://doaj.org/article/33b287e44820486d83f59d48f1b7e203 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001476 |
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PLoS Neglected Tropical Diseases |
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6 |
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2 |
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e1476 |
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