Modulation of the Expression of Immune-related Gene in Atlantic and Coho Salmon during Infestation with the Sea lice Caligus rogercresseyi

Caligus rogercresseyi , a marine ectoparasite, causes notable economic losses for the Chilean salmonid industry. Nevertheless, the immunological responses of infected fish remain poorly understood, including proinflammatory cytokine generation and the respective modulatory effects of various cytokin...

Full description

Bibliographic Details
Published in:Fishes
Main Authors: Juan Pablo Pontigo, Julia Saravia, Ricardo Oyarzún, Margarita P. González, Christopher Hawes, Francisco J. Morera, Jorge Pino, Simon Wadsworth, Jose Luis P. Muñoz, Luis Vargas-Chacoff
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2019
Subjects:
NLRC5
cytokines
sea lice
immune response
Salmo salar
Oncorhynchus kisutch
Biology (General)
QH301-705.5
Genetics
QH426-470
Atlantic salmon
Online Access:https://doi.org/10.3390/fishes4030042
https://doaj.org/article/33b1d8713de94994bda917c054d516ce
Description
Summary:Caligus rogercresseyi , a marine ectoparasite, causes notable economic losses for the Chilean salmonid industry. Nevertheless, the immunological responses of infected fish remain poorly understood, including proinflammatory cytokine generation and the respective modulatory effects of various cytokine receptors. This study evaluated mRNA expression of the NLRC5, major histocompatibility complex (MHC) class II, I-kappa-B-alpha, a regulatory that inhibits NF-kappa-B, and proinflammatory cytokines (IL-1β and IL-18) in the liver and muscle of Atlantic salmon ( Salmo salar ) and Coho salmon ( Oncorhynchus kisutch ) during a time-course C. rogercresseyi infestation trial. All assessed mRNA were strongly regulated during infestation, but S. salar showed up-regulated expression, possibly accounting for the high infestation vulnerability of this salmonid. In conclusion, this work helps to understand the modulation of the expression of different transcripts involved over short periods of C. rogercresseyi infestation in two salmonid species ( S. salar and O. kisutch ).

Similar Items