Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral
In October 2000, the Ministries of Health of the Dominican Republic and Haiti notified two cases of acute flaccid paralysis (AFP) in rural areas, one of them in a 9-month-old female, and the other in a 2-year-old female, respectively. Stool samples that were obtained from these cases, which occurred...
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Pan American Health Organization
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ftdoajarticles:oai:doaj.org/article:3399451a302a47848ff3bd6961c900c9 2023-05-15T15:12:55+02:00 Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral Landaverde Mauricio Venczel Linda Quadros Ciro A. de 2001-01-01T00:00:00Z https://doaj.org/article/3399451a302a47848ff3bd6961c900c9 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892001000400017 https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/3399451a302a47848ff3bd6961c900c9 Revista Panamericana de Salud Pública, Vol 9, Iss 4, Pp 272-274 (2001) Poliovirus salvaje parálisis flácida aguda poliomielitis vacuna antipoliomielítica oral Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2001 ftdoajarticles 2022-12-31T03:17:31Z In October 2000, the Ministries of Health of the Dominican Republic and Haiti notified two cases of acute flaccid paralysis (AFP) in rural areas, one of them in a 9-month-old female, and the other in a 2-year-old female, respectively. Stool samples that were obtained from these cases, which occurred in July and August 2000, after a 9-year interruption of wild poliovirus circulation in the Western Hemisphere, revealed the presence of type 1 poliovirus. Genetic sequencing, which was later performed at the Centers for Disease Control and Prevention, in Atlanta, Georgia, United States of America, revealed an atypical descendant of the virus used in the manufacture of the oral polio vaccine (OPV), but with 3% genetic divergence with respect to the parent strain. Normally, viral isolates that derive from vaccine components show 99.5% genetic agreement with the parent strain; in wild polioviruses, on the other hand, this agreement is usually less than 82.0%. Thus, the 3% genetic divergence detected in this study suggests that, in areas with low vaccine coverage, the virus used in the vaccine remained in circulation for at least two years, during which it recovered the neurovirulence and communicability of wild poliovirus type 1. This report describes the characteristics and results of the active search for cases of AFP that was sparked by the detection of the two index cases. It also looks at the public health implications of this outbreak for the entire Region of the Americas. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Poliovirus salvaje parálisis flácida aguda poliomielitis vacuna antipoliomielítica oral Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Poliovirus salvaje parálisis flácida aguda poliomielitis vacuna antipoliomielítica oral Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Landaverde Mauricio Venczel Linda Quadros Ciro A. de Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral |
topic_facet |
Poliovirus salvaje parálisis flácida aguda poliomielitis vacuna antipoliomielítica oral Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In October 2000, the Ministries of Health of the Dominican Republic and Haiti notified two cases of acute flaccid paralysis (AFP) in rural areas, one of them in a 9-month-old female, and the other in a 2-year-old female, respectively. Stool samples that were obtained from these cases, which occurred in July and August 2000, after a 9-year interruption of wild poliovirus circulation in the Western Hemisphere, revealed the presence of type 1 poliovirus. Genetic sequencing, which was later performed at the Centers for Disease Control and Prevention, in Atlanta, Georgia, United States of America, revealed an atypical descendant of the virus used in the manufacture of the oral polio vaccine (OPV), but with 3% genetic divergence with respect to the parent strain. Normally, viral isolates that derive from vaccine components show 99.5% genetic agreement with the parent strain; in wild polioviruses, on the other hand, this agreement is usually less than 82.0%. Thus, the 3% genetic divergence detected in this study suggests that, in areas with low vaccine coverage, the virus used in the vaccine remained in circulation for at least two years, during which it recovered the neurovirulence and communicability of wild poliovirus type 1. This report describes the characteristics and results of the active search for cases of AFP that was sparked by the detection of the two index cases. It also looks at the public health implications of this outbreak for the entire Region of the Americas. |
format |
Article in Journal/Newspaper |
author |
Landaverde Mauricio Venczel Linda Quadros Ciro A. de |
author_facet |
Landaverde Mauricio Venczel Linda Quadros Ciro A. de |
author_sort |
Landaverde Mauricio |
title |
Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral |
title_short |
Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral |
title_full |
Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral |
title_fullStr |
Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral |
title_full_unstemmed |
Brote de poliomielitis en Haití y la República Dominicana debido a un virus derivado de la vacuna antipoliomielítica oral |
title_sort |
brote de poliomielitis en haití y la república dominicana debido a un virus derivado de la vacuna antipoliomielítica oral |
publisher |
Pan American Health Organization |
publishDate |
2001 |
url |
https://doaj.org/article/3399451a302a47848ff3bd6961c900c9 |
long_lat |
ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Arctic Aguda |
geographic_facet |
Arctic Aguda |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 9, Iss 4, Pp 272-274 (2001) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892001000400017 https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/3399451a302a47848ff3bd6961c900c9 |
_version_ |
1766343540020871168 |