Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR
Abstract Background The erythrocyte binding antigen 175 (EBA-175) is a 175 kDa antigen of Plasmodium falciparum and plays a major role in erythrocyte recognition by the parasite. The antigen is also supposed to be partly responsible for the invasion of erythrocytes by merozoites. EBA-175 has been se...
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ftdoajarticles:oai:doaj.org/article:337608cb65ff413fb5a960a36ce8ec7f 2023-05-15T15:10:12+02:00 Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR Rattanaxay Phetsouvanh Vanisaveth Vienxay Jordan Sabine Schwöbel Babett Dittrich Sabine Christophel Eva M Phompida Samlane Jelinek Tomas 2003-07-01T00:00:00Z https://doi.org/10.1186/1475-2875-2-23 https://doaj.org/article/337608cb65ff413fb5a960a36ce8ec7f EN eng BMC http://www.malariajournal.com/content/2/1/23 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-2-23 1475-2875 https://doaj.org/article/337608cb65ff413fb5a960a36ce8ec7f Malaria Journal, Vol 2, Iss 1, p 23 (2003) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2003 ftdoajarticles https://doi.org/10.1186/1475-2875-2-23 2022-12-31T08:33:05Z Abstract Background The erythrocyte binding antigen 175 (EBA-175) is a 175 kDa antigen of Plasmodium falciparum and plays a major role in erythrocyte recognition by the parasite. The antigen is also supposed to be partly responsible for the invasion of erythrocytes by merozoites. EBA-175 has been sequenced from the FCR-3 and CAMP strains of P. falciparum. The sequences were identical in most parts of the gene. Differences were apparent in a 423 bp segment in the FCR-3 strain, the F-Fragment, that is not found in the CAMP-strain and a 342 bp segment, the C-Fragment, which is present in the CAMP-strain but not in the FCR-3-strain. The aim of this study was to assess the distribution of the two EBA-175-alleles in the Lao PDR. Materials & Methods Altogether, 240 blood-samples were collected in two areas of the country: Attapeu in the south and Lung Namtha in the north. Subsequently, the material was scanned for the F-and C-fragments. Results In the whole study population, 52% carried the F-fragment, and 41% the C-fragment while seven percent of the patients were infected with at least two parasite strains and showed both alleles. Conclusion Distribution of the alleles showed significant differences between the north and the south province. Reasons for this include possible importation of different parasite strains from neighbouring countries. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 2 1 23 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Rattanaxay Phetsouvanh Vanisaveth Vienxay Jordan Sabine Schwöbel Babett Dittrich Sabine Christophel Eva M Phompida Samlane Jelinek Tomas Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The erythrocyte binding antigen 175 (EBA-175) is a 175 kDa antigen of Plasmodium falciparum and plays a major role in erythrocyte recognition by the parasite. The antigen is also supposed to be partly responsible for the invasion of erythrocytes by merozoites. EBA-175 has been sequenced from the FCR-3 and CAMP strains of P. falciparum. The sequences were identical in most parts of the gene. Differences were apparent in a 423 bp segment in the FCR-3 strain, the F-Fragment, that is not found in the CAMP-strain and a 342 bp segment, the C-Fragment, which is present in the CAMP-strain but not in the FCR-3-strain. The aim of this study was to assess the distribution of the two EBA-175-alleles in the Lao PDR. Materials & Methods Altogether, 240 blood-samples were collected in two areas of the country: Attapeu in the south and Lung Namtha in the north. Subsequently, the material was scanned for the F-and C-fragments. Results In the whole study population, 52% carried the F-fragment, and 41% the C-fragment while seven percent of the patients were infected with at least two parasite strains and showed both alleles. Conclusion Distribution of the alleles showed significant differences between the north and the south province. Reasons for this include possible importation of different parasite strains from neighbouring countries. |
format |
Article in Journal/Newspaper |
author |
Rattanaxay Phetsouvanh Vanisaveth Vienxay Jordan Sabine Schwöbel Babett Dittrich Sabine Christophel Eva M Phompida Samlane Jelinek Tomas |
author_facet |
Rattanaxay Phetsouvanh Vanisaveth Vienxay Jordan Sabine Schwöbel Babett Dittrich Sabine Christophel Eva M Phompida Samlane Jelinek Tomas |
author_sort |
Rattanaxay Phetsouvanh |
title |
Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR |
title_short |
Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR |
title_full |
Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR |
title_fullStr |
Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR |
title_full_unstemmed |
Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR |
title_sort |
distribution of the two forms of plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in lao pdr |
publisher |
BMC |
publishDate |
2003 |
url |
https://doi.org/10.1186/1475-2875-2-23 https://doaj.org/article/337608cb65ff413fb5a960a36ce8ec7f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 2, Iss 1, p 23 (2003) |
op_relation |
http://www.malariajournal.com/content/2/1/23 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-2-23 1475-2875 https://doaj.org/article/337608cb65ff413fb5a960a36ce8ec7f |
op_doi |
https://doi.org/10.1186/1475-2875-2-23 |
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Malaria Journal |
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2 |
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