Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers
Abstract INTRODUCTION: The present study investigated the association of the rs2794521 polymorphism in the CRP gene in individuals with chronic hepatitis B and C, correlating it with markers of hepatic inflammation, fibrosis scores, viral load, and plasma protein levels. METHODS: The study analyzed...
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ftdoajarticles:oai:doaj.org/article:337549f6d0f04f6293af61a7e19bd7f0 2023-05-15T15:08:43+02:00 Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers Tuane Carolina Ferreira Moura Ednelza da Silva Graça Amoras Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Alan Barroso Araújo Grisólia Ricardo Ishak Antonio Carlos Rosário Vallinoto 2019-02-01T00:00:00Z https://doi.org/10.1590/0037-8682-0455-2018 https://doaj.org/article/337549f6d0f04f6293af61a7e19bd7f0 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100308&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0455-2018 https://doaj.org/article/337549f6d0f04f6293af61a7e19bd7f0 Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) C-reactive protein SNP HBV HCV Viremia Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1590/0037-8682-0455-2018 2022-12-31T02:59:03Z Abstract INTRODUCTION: The present study investigated the association of the rs2794521 polymorphism in the CRP gene in individuals with chronic hepatitis B and C, correlating it with markers of hepatic inflammation, fibrosis scores, viral load, and plasma protein levels. METHODS: The study analyzed 185 blood samples obtained from patients with hepatitis B (n=74) and hepatitis C (n=111) and 300 samples from healthy donors. Genotyping was performed by real-time polymerase chain reaction, and protein levels were quantified using the automated immunoturbidimetric method. RESULTS: The TT genotype was the most frequent in all studied groups and was associated with higher plasma levels of the protein but not with the progression of liver disease. Low levels of C-reactive protein were associated with increased viremia and scores indicative of severe fibrosis and cirrhosis. CONCLUSIONS: The present results demonstrated a close relationship between the ability of the virus to replicate and cause liver damage and low serum concentrations of C-reactive protein. Future research may determine if these results can be interpreted as a possible form of escape for the virus by decreasing its action as an opsonin and decreasing phagocytosis, which are functions of C-reactive protein in the immune response. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 52 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
C-reactive protein SNP HBV HCV Viremia Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
C-reactive protein SNP HBV HCV Viremia Arctic medicine. Tropical medicine RC955-962 Tuane Carolina Ferreira Moura Ednelza da Silva Graça Amoras Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Alan Barroso Araújo Grisólia Ricardo Ishak Antonio Carlos Rosário Vallinoto Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers |
topic_facet |
C-reactive protein SNP HBV HCV Viremia Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: The present study investigated the association of the rs2794521 polymorphism in the CRP gene in individuals with chronic hepatitis B and C, correlating it with markers of hepatic inflammation, fibrosis scores, viral load, and plasma protein levels. METHODS: The study analyzed 185 blood samples obtained from patients with hepatitis B (n=74) and hepatitis C (n=111) and 300 samples from healthy donors. Genotyping was performed by real-time polymerase chain reaction, and protein levels were quantified using the automated immunoturbidimetric method. RESULTS: The TT genotype was the most frequent in all studied groups and was associated with higher plasma levels of the protein but not with the progression of liver disease. Low levels of C-reactive protein were associated with increased viremia and scores indicative of severe fibrosis and cirrhosis. CONCLUSIONS: The present results demonstrated a close relationship between the ability of the virus to replicate and cause liver damage and low serum concentrations of C-reactive protein. Future research may determine if these results can be interpreted as a possible form of escape for the virus by decreasing its action as an opsonin and decreasing phagocytosis, which are functions of C-reactive protein in the immune response. |
format |
Article in Journal/Newspaper |
author |
Tuane Carolina Ferreira Moura Ednelza da Silva Graça Amoras Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Alan Barroso Araújo Grisólia Ricardo Ishak Antonio Carlos Rosário Vallinoto |
author_facet |
Tuane Carolina Ferreira Moura Ednelza da Silva Graça Amoras Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Alan Barroso Araújo Grisólia Ricardo Ishak Antonio Carlos Rosário Vallinoto |
author_sort |
Tuane Carolina Ferreira Moura |
title |
Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers |
title_short |
Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers |
title_full |
Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers |
title_fullStr |
Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers |
title_full_unstemmed |
Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers |
title_sort |
association of serum levels of c-reactive protein with crp-717 t/c polymorphism and viremia in hcv and hbv carriers |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2019 |
url |
https://doi.org/10.1590/0037-8682-0455-2018 https://doaj.org/article/337549f6d0f04f6293af61a7e19bd7f0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100308&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0455-2018 https://doaj.org/article/337549f6d0f04f6293af61a7e19bd7f0 |
op_doi |
https://doi.org/10.1590/0037-8682-0455-2018 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
52 |
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