Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016
Abstract Background The World Health Organization recommends the use of artemisinin-based combination therapy (ACT) to treat uncomplicated malaria for the control of malaria across the world. There are several types of ACT used across malaria-endemic countries, yet there is little information about...
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ftdoajarticles:oai:doaj.org/article:33617141a3254c28a8b0046b267a2b0a 2023-05-15T15:15:13+02:00 Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016 Alioune Camara Leah F. Moriarty Timothée Guilavogui Papa Sambou Diakité Joseph Souba Zoumanigui Sidikiba Sidibé Ibrahima Bah Ibrahima Kaba Djebory Kourouma Koho Zoumanigui Mateusz Plucinski 2019-01-01T00:00:00Z https://doi.org/10.1186/s12936-019-2664-7 https://doaj.org/article/33617141a3254c28a8b0046b267a2b0a EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2664-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2664-7 1475-2875 https://doaj.org/article/33617141a3254c28a8b0046b267a2b0a Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) Malaria Adherence Drug intake Lumefantrine Amodiaquine Guinea Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2664-7 2022-12-31T12:48:05Z Abstract Background The World Health Organization recommends the use of artemisinin-based combination therapy (ACT) to treat uncomplicated malaria for the control of malaria across the world. There are several types of ACT used across malaria-endemic countries, yet there is little information about preferences and adherence practices regarding different types of ACT. The objective of this study was to evaluate levels of adherence to two types of ACT, artemether–lumefantrine (AL) and artesunate + amodiaquine (ASAQ), for the treatment of uncomplicated malaria among prescribers and patients in Guinea in 2016. Methods The study included a review of records of malaria patients and three health-facility, cross-sectional surveys. Patients diagnosed with uncomplicated malaria and prescribed ACT (n = 1830) were recruited and visited in their home after receiving the medication and administered a questionnaire regarding ACT adherence. Prescribers (n = 115) and drug dispensers (n = 43) were recruited at the same public health facilities and administered questionnaires regarding prescribing practices and opinions regarding the national treatment policies and protocols. Results According to the registry review, 35.8% of all-cause consultations were recorded as malaria. Of these, 26.6% were diagnosed clinically without documentation of laboratory confirmation. The diagnosis of uncomplicated malaria represented 64.1% of malaria cases among children under 5 years and 74.9% of those 5 years of age and older. An ACT was prescribed for 83.5% of cases of uncomplicated malaria. Among participants in the study, ACT adherence was 95.4% (95% CI 94.4, 96.3). Overall, about one in four patients (23.4%; 95% CI 21.5, 25.3) reported experiencing adverse events. While patients prescribed ASAQ were significantly more likely to report experiencing adverse effects than patients on AL (p < 0.001), given the overall high adherence, there was no evidence of a statistically significant difference in adherence between AL and ASAQ. Patients 5 ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Malaria Adherence Drug intake Lumefantrine Amodiaquine Guinea Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Adherence Drug intake Lumefantrine Amodiaquine Guinea Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Alioune Camara Leah F. Moriarty Timothée Guilavogui Papa Sambou Diakité Joseph Souba Zoumanigui Sidikiba Sidibé Ibrahima Bah Ibrahima Kaba Djebory Kourouma Koho Zoumanigui Mateusz Plucinski Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016 |
topic_facet |
Malaria Adherence Drug intake Lumefantrine Amodiaquine Guinea Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The World Health Organization recommends the use of artemisinin-based combination therapy (ACT) to treat uncomplicated malaria for the control of malaria across the world. There are several types of ACT used across malaria-endemic countries, yet there is little information about preferences and adherence practices regarding different types of ACT. The objective of this study was to evaluate levels of adherence to two types of ACT, artemether–lumefantrine (AL) and artesunate + amodiaquine (ASAQ), for the treatment of uncomplicated malaria among prescribers and patients in Guinea in 2016. Methods The study included a review of records of malaria patients and three health-facility, cross-sectional surveys. Patients diagnosed with uncomplicated malaria and prescribed ACT (n = 1830) were recruited and visited in their home after receiving the medication and administered a questionnaire regarding ACT adherence. Prescribers (n = 115) and drug dispensers (n = 43) were recruited at the same public health facilities and administered questionnaires regarding prescribing practices and opinions regarding the national treatment policies and protocols. Results According to the registry review, 35.8% of all-cause consultations were recorded as malaria. Of these, 26.6% were diagnosed clinically without documentation of laboratory confirmation. The diagnosis of uncomplicated malaria represented 64.1% of malaria cases among children under 5 years and 74.9% of those 5 years of age and older. An ACT was prescribed for 83.5% of cases of uncomplicated malaria. Among participants in the study, ACT adherence was 95.4% (95% CI 94.4, 96.3). Overall, about one in four patients (23.4%; 95% CI 21.5, 25.3) reported experiencing adverse events. While patients prescribed ASAQ were significantly more likely to report experiencing adverse effects than patients on AL (p < 0.001), given the overall high adherence, there was no evidence of a statistically significant difference in adherence between AL and ASAQ. Patients 5 ... |
format |
Article in Journal/Newspaper |
author |
Alioune Camara Leah F. Moriarty Timothée Guilavogui Papa Sambou Diakité Joseph Souba Zoumanigui Sidikiba Sidibé Ibrahima Bah Ibrahima Kaba Djebory Kourouma Koho Zoumanigui Mateusz Plucinski |
author_facet |
Alioune Camara Leah F. Moriarty Timothée Guilavogui Papa Sambou Diakité Joseph Souba Zoumanigui Sidikiba Sidibé Ibrahima Bah Ibrahima Kaba Djebory Kourouma Koho Zoumanigui Mateusz Plucinski |
author_sort |
Alioune Camara |
title |
Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016 |
title_short |
Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016 |
title_full |
Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016 |
title_fullStr |
Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016 |
title_full_unstemmed |
Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016 |
title_sort |
prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in guinea, 2016 |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2664-7 https://doaj.org/article/33617141a3254c28a8b0046b267a2b0a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2664-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2664-7 1475-2875 https://doaj.org/article/33617141a3254c28a8b0046b267a2b0a |
op_doi |
https://doi.org/10.1186/s12936-019-2664-7 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766345588409892864 |