Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts.
Background Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody responses in naturally infected people from endemic settings. To address this question, we studied IgG respo...
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ftdoajarticles:oai:doaj.org/article:33595670dd624a9fb7671be1f3a6e68f 2023-05-15T15:16:49+02:00 Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. Jason Rosado Michael T White Rhea J Longley Marcus Lacerda Wuelton Monteiro Jessica Brewster Jetsumon Sattabongkot Mitchel Guzman-Guzman Alejandro Llanos-Cuentas Joseph M Vinetz Dionicia Gamboa Ivo Mueller 2021-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009165 https://doaj.org/article/33595670dd624a9fb7671be1f3a6e68f EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009165 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009165 https://doaj.org/article/33595670dd624a9fb7671be1f3a6e68f PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009165 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009165 2022-12-30T20:23:39Z Background Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody responses in naturally infected people from endemic settings. To address this question, we studied IgG responses to novel serological exposure markers (SEMs) of P. vivax in three settings with different transmission intensity. Methodology We validated a panel of 34 SEMs in a Peruvian cohort with up to three years' longitudinal follow-up using a multiplex platform and compared results to data from cohorts in Thailand and Brazil. Linear regression models were used to characterize the association between antibody responses and age, the number of detected blood-stage infections during follow-up, and time since previous infection. Receiver Operating Characteristic (ROC) analysis was used to test the performance of SEMs to identify P. vivax infections in the previous 9 months. Principal findings Antibody titers were associated with age, the number of blood-stage infections, and time since previous P. vivax infection in all three study sites. The association between antibody titers and time since previous P. vivax infection was stronger in the low transmission settings of Thailand and Brazil compared to the higher transmission setting in Peru. Of the SEMs tested, antibody responses to RBP2b had the highest performance for classifying recent exposure in all sites, with area under the ROC curve (AUC) = 0.83 in Thailand, AUC = 0.79 in Brazil, and AUC = 0.68 in Peru. Conclusions In low transmission settings, P. vivax SEMs can accurately identify individuals with recent blood-stage infections. In higher transmission settings, the accuracy of this approach diminishes substantially. We recommend using P. vivax SEMs in low transmission settings pursuing malaria elimination, but they are likely to be less effective in high transmission settings focused on malaria control. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 2 e0009165 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jason Rosado Michael T White Rhea J Longley Marcus Lacerda Wuelton Monteiro Jessica Brewster Jetsumon Sattabongkot Mitchel Guzman-Guzman Alejandro Llanos-Cuentas Joseph M Vinetz Dionicia Gamboa Ivo Mueller Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody responses in naturally infected people from endemic settings. To address this question, we studied IgG responses to novel serological exposure markers (SEMs) of P. vivax in three settings with different transmission intensity. Methodology We validated a panel of 34 SEMs in a Peruvian cohort with up to three years' longitudinal follow-up using a multiplex platform and compared results to data from cohorts in Thailand and Brazil. Linear regression models were used to characterize the association between antibody responses and age, the number of detected blood-stage infections during follow-up, and time since previous infection. Receiver Operating Characteristic (ROC) analysis was used to test the performance of SEMs to identify P. vivax infections in the previous 9 months. Principal findings Antibody titers were associated with age, the number of blood-stage infections, and time since previous P. vivax infection in all three study sites. The association between antibody titers and time since previous P. vivax infection was stronger in the low transmission settings of Thailand and Brazil compared to the higher transmission setting in Peru. Of the SEMs tested, antibody responses to RBP2b had the highest performance for classifying recent exposure in all sites, with area under the ROC curve (AUC) = 0.83 in Thailand, AUC = 0.79 in Brazil, and AUC = 0.68 in Peru. Conclusions In low transmission settings, P. vivax SEMs can accurately identify individuals with recent blood-stage infections. In higher transmission settings, the accuracy of this approach diminishes substantially. We recommend using P. vivax SEMs in low transmission settings pursuing malaria elimination, but they are likely to be less effective in high transmission settings focused on malaria control. |
format |
Article in Journal/Newspaper |
author |
Jason Rosado Michael T White Rhea J Longley Marcus Lacerda Wuelton Monteiro Jessica Brewster Jetsumon Sattabongkot Mitchel Guzman-Guzman Alejandro Llanos-Cuentas Joseph M Vinetz Dionicia Gamboa Ivo Mueller |
author_facet |
Jason Rosado Michael T White Rhea J Longley Marcus Lacerda Wuelton Monteiro Jessica Brewster Jetsumon Sattabongkot Mitchel Guzman-Guzman Alejandro Llanos-Cuentas Joseph M Vinetz Dionicia Gamboa Ivo Mueller |
author_sort |
Jason Rosado |
title |
Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. |
title_short |
Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. |
title_full |
Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. |
title_fullStr |
Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. |
title_full_unstemmed |
Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. |
title_sort |
heterogeneity in response to serological exposure markers of recent plasmodium vivax infections in contrasting epidemiological contexts. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009165 https://doaj.org/article/33595670dd624a9fb7671be1f3a6e68f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009165 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009165 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009165 https://doaj.org/article/33595670dd624a9fb7671be1f3a6e68f |
op_doi |
https://doi.org/10.1371/journal.pntd.0009165 |
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PLOS Neglected Tropical Diseases |
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15 |
container_issue |
2 |
container_start_page |
e0009165 |
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