Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study
Abstract Background Tuberculosis (TB) is a major public health concern in the developing countries. Moreover, the emergence of multidrug-resistant tuberculosis is challenging. However, there are no organized data on the trends of pulmonary tuberculosis and rifampicin-resistant Mycobacterium tubercul...
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ftdoajarticles:oai:doaj.org/article:32f922b213c04ee4b98bb428cb8d4a2e 2024-09-09T19:27:32+00:00 Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study Guesh Gebremariam Mulugeta Kiros Selemun Hagos Haftom Hadush Amaha Gebremichael Gebretsadkan Gebrekirstos Aregawi Tesfay Teumelsan Gebrewahid Tesfay Berihu Brhane Gebremariam 2024-07-01T00:00:00Z https://doi.org/10.1186/s40794-024-00224-1 https://doaj.org/article/32f922b213c04ee4b98bb428cb8d4a2e EN eng BMC https://doi.org/10.1186/s40794-024-00224-1 https://doaj.org/toc/2055-0936 doi:10.1186/s40794-024-00224-1 2055-0936 https://doaj.org/article/32f922b213c04ee4b98bb428cb8d4a2e Tropical Diseases, Travel Medicine and Vaccines, Vol 10, Iss 1, Pp 1-9 (2024) Trend Tuberculosis Retrospective X-pert MTB/Rif assay Central Tigray Arctic medicine. Tropical medicine RC955-962 article 2024 ftdoajarticles https://doi.org/10.1186/s40794-024-00224-1 2024-08-05T17:49:00Z Abstract Background Tuberculosis (TB) is a major public health concern in the developing countries. Moreover, the emergence of multidrug-resistant tuberculosis is challenging. However, there are no organized data on the trends of pulmonary tuberculosis and rifampicin-resistant Mycobacterium tuberculosis in the study area. Methods A retrospective cross-sectional study was conducted to fill the information gap in Central Tigray at St. Mary General Hospital between 2018 and 2023. Data were collected from the GeneXpert™ tuberculosis registration logbooks using standard checklists and analyzed using Statistical Package for Social Science version 22. After performing logistic regression, a p-value < 0.05 with a corresponding 95% confidence interval was considered statistically significant. Moreover, chi square test for trend was performed to assess the percentage of annual detection of pulmonary tuberculosis and rifampicin-resistant Mycobacterium tuberculosis during the study years. Result Presumptive pulmonary tuberculosis patients with complete data (n = 3696) were included in the study. The overall prevalence of pulmonary tuberculosis was 11.7%, of which 8.1% were resistant to rifampicin. The study revealed that the incidence of pulmonary tuberculosis has been increasing, mainly in the recent four years. Likewise, an increase in rifampicin-resistant Mycobacterium tuberculosis was observed with considerable fluctuations. Age, human immunodeficiency virus infection, and presumptive rifampicin-resistant Mycobacterium tuberculosis infection were significantly associated with the presence of pulmonary tuberculosis. Moreover, pulmonary tuberculosis was more prevalent among participants in the productive-age group. Conclusion Although there have been fluctuations, an increasing of pulmonary tuberculosis and rifampicin-resistant Mycobacterium tuberculosis has been observed in recent years. Hence, prevention and treatment strategies for tuberculosis should be strengthened to alleviate the burden of pulmonary tuberculosis ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Rif ENVELOPE(-16.172,-16.172,66.526,66.526) Tropical Diseases, Travel Medicine and Vaccines 10 1 |
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Trend Tuberculosis Retrospective X-pert MTB/Rif assay Central Tigray Arctic medicine. Tropical medicine RC955-962 |
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Trend Tuberculosis Retrospective X-pert MTB/Rif assay Central Tigray Arctic medicine. Tropical medicine RC955-962 Guesh Gebremariam Mulugeta Kiros Selemun Hagos Haftom Hadush Amaha Gebremichael Gebretsadkan Gebrekirstos Aregawi Tesfay Teumelsan Gebrewahid Tesfay Berihu Brhane Gebremariam Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study |
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Trend Tuberculosis Retrospective X-pert MTB/Rif assay Central Tigray Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Tuberculosis (TB) is a major public health concern in the developing countries. Moreover, the emergence of multidrug-resistant tuberculosis is challenging. However, there are no organized data on the trends of pulmonary tuberculosis and rifampicin-resistant Mycobacterium tuberculosis in the study area. Methods A retrospective cross-sectional study was conducted to fill the information gap in Central Tigray at St. Mary General Hospital between 2018 and 2023. Data were collected from the GeneXpert™ tuberculosis registration logbooks using standard checklists and analyzed using Statistical Package for Social Science version 22. After performing logistic regression, a p-value < 0.05 with a corresponding 95% confidence interval was considered statistically significant. Moreover, chi square test for trend was performed to assess the percentage of annual detection of pulmonary tuberculosis and rifampicin-resistant Mycobacterium tuberculosis during the study years. Result Presumptive pulmonary tuberculosis patients with complete data (n = 3696) were included in the study. The overall prevalence of pulmonary tuberculosis was 11.7%, of which 8.1% were resistant to rifampicin. The study revealed that the incidence of pulmonary tuberculosis has been increasing, mainly in the recent four years. Likewise, an increase in rifampicin-resistant Mycobacterium tuberculosis was observed with considerable fluctuations. Age, human immunodeficiency virus infection, and presumptive rifampicin-resistant Mycobacterium tuberculosis infection were significantly associated with the presence of pulmonary tuberculosis. Moreover, pulmonary tuberculosis was more prevalent among participants in the productive-age group. Conclusion Although there have been fluctuations, an increasing of pulmonary tuberculosis and rifampicin-resistant Mycobacterium tuberculosis has been observed in recent years. Hence, prevention and treatment strategies for tuberculosis should be strengthened to alleviate the burden of pulmonary tuberculosis ... |
format |
Article in Journal/Newspaper |
author |
Guesh Gebremariam Mulugeta Kiros Selemun Hagos Haftom Hadush Amaha Gebremichael Gebretsadkan Gebrekirstos Aregawi Tesfay Teumelsan Gebrewahid Tesfay Berihu Brhane Gebremariam |
author_facet |
Guesh Gebremariam Mulugeta Kiros Selemun Hagos Haftom Hadush Amaha Gebremichael Gebretsadkan Gebrekirstos Aregawi Tesfay Teumelsan Gebrewahid Tesfay Berihu Brhane Gebremariam |
author_sort |
Guesh Gebremariam |
title |
Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study |
title_short |
Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study |
title_full |
Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study |
title_fullStr |
Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study |
title_full_unstemmed |
Trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in Central Tigray, Ethiopia; 2018 -2023: a six-year retrospective study |
title_sort |
trend of pulmonary tuberculosis and rifampicin-resistance among tuberculosis presumptive patients in central tigray, ethiopia; 2018 -2023: a six-year retrospective study |
publisher |
BMC |
publishDate |
2024 |
url |
https://doi.org/10.1186/s40794-024-00224-1 https://doaj.org/article/32f922b213c04ee4b98bb428cb8d4a2e |
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ENVELOPE(-16.172,-16.172,66.526,66.526) |
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Arctic Rif |
geographic_facet |
Arctic Rif |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Diseases, Travel Medicine and Vaccines, Vol 10, Iss 1, Pp 1-9 (2024) |
op_relation |
https://doi.org/10.1186/s40794-024-00224-1 https://doaj.org/toc/2055-0936 doi:10.1186/s40794-024-00224-1 2055-0936 https://doaj.org/article/32f922b213c04ee4b98bb428cb8d4a2e |
op_doi |
https://doi.org/10.1186/s40794-024-00224-1 |
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Tropical Diseases, Travel Medicine and Vaccines |
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10 |
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1 |
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1809896965587075072 |