Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010
Background. Oropharyngeal squamous cell carcinoma (OPSCC) is associated with the sexually transmitted human papillomavirus (HPV), smoking and alcohol. In Greenland, a high rate of HPV-induced cervical cancer and venereal diseases are found, which exposes the population for high risk of HPV infection...
Published in: | International Journal of Circumpolar Health |
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Taylor & Francis Group
2013
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ftdoajarticles:oai:doaj.org/article:32dbf4287efa4da895de27bcebf41477 2023-05-15T15:17:47+02:00 Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010 Magnus Balslev Avnstorp Ramon Gordon Jensen Emilie Garnæs Marianne Hamilton Therkildsen Bodil Norrild Lena Specht Christian von Buchwald Preben Homøe 2013-11-01T00:00:00Z https://doi.org/10.3402/ijch.v72i0.22386 https://doaj.org/article/32dbf4287efa4da895de27bcebf41477 EN eng Taylor & Francis Group www.circumpolarhealthjournal.net/index.php/ijch/article/download/22386/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.22386 2242-3982 https://doaj.org/article/32dbf4287efa4da895de27bcebf41477 International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-7 (2013) head and neck cancer HPV Inuit p16 immunohistochemistry PCR HPV vaccine immunization Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.3402/ijch.v72i0.22386 2022-12-31T01:52:30Z Background. Oropharyngeal squamous cell carcinoma (OPSCC) is associated with the sexually transmitted human papillomavirus (HPV), smoking and alcohol. In Greenland, a high rate of HPV-induced cervical cancer and venereal diseases are found, which exposes the population for high risk of HPV infection. In Greenland, only girls are included in the mandatory HPV vaccination program. Objective. To investigate the annual incidence of OPSCC and the proportion of HPV-associated OPSCC (HPV+ OPSCC) in Greenland in 1994–2010. Design. At Rigshospitalet, University of Copenhagen, we identified all Greenlandic patients diagnosed and treated for OPSCC from 1994 to 2010. Sections were cut from the patient's paraffin-embedded tissue blocks and investigated for p16 expression by immunohistochemistry. HPV analyses were performed with 2 sets of general HPV primers and 1 set of HPV16-specific primer. HPV+ OPSCC was defined as both >75% p16+ cells and PCR positive for HPV. Results. Of 26 Greenlandic patients diagnosed with OPSCC, 17 were males and 9 were females. The proportion of HPV+ OPSCC in the total study period was 22%, without significant changes in the population in Greenland. We found an increase in the proportion of HPV+ OPSCC from 14% in 1994–2001 to 25% in 2002–2010 (p=0.51). Among males from 20 to 27% (p=0.63) and in females from 0 to 20% (p=0.71). The annual OPSCC incidence increased from 2.3/100,000 (CI=1.2–4.2) in 1994–2001 to 3.8/100,000 (CI=2.4–6.2) in 2002–2010: among males from 2.4/100,000 (CI=1.0–5.7) to 5.0/100,000 (CI=2.9–8.9). Conclusion. Even though the population is at high risk of HPV infection, the proportion of 22% HPV+ OPSCC in the total study period is low compared to Europe and the United States. This might be explained by our small study size and/or by ethnic, geographical, sexual and cultural differences. Continuing observations of the OPSCC incidence and the proportion of HPV+ ... Article in Journal/Newspaper Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health inuit Directory of Open Access Journals: DOAJ Articles Arctic Greenland International Journal of Circumpolar Health 72 1 22386 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
head and neck cancer HPV Inuit p16 immunohistochemistry PCR HPV vaccine immunization Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
head and neck cancer HPV Inuit p16 immunohistochemistry PCR HPV vaccine immunization Arctic medicine. Tropical medicine RC955-962 Magnus Balslev Avnstorp Ramon Gordon Jensen Emilie Garnæs Marianne Hamilton Therkildsen Bodil Norrild Lena Specht Christian von Buchwald Preben Homøe Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010 |
topic_facet |
head and neck cancer HPV Inuit p16 immunohistochemistry PCR HPV vaccine immunization Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Oropharyngeal squamous cell carcinoma (OPSCC) is associated with the sexually transmitted human papillomavirus (HPV), smoking and alcohol. In Greenland, a high rate of HPV-induced cervical cancer and venereal diseases are found, which exposes the population for high risk of HPV infection. In Greenland, only girls are included in the mandatory HPV vaccination program. Objective. To investigate the annual incidence of OPSCC and the proportion of HPV-associated OPSCC (HPV+ OPSCC) in Greenland in 1994–2010. Design. At Rigshospitalet, University of Copenhagen, we identified all Greenlandic patients diagnosed and treated for OPSCC from 1994 to 2010. Sections were cut from the patient's paraffin-embedded tissue blocks and investigated for p16 expression by immunohistochemistry. HPV analyses were performed with 2 sets of general HPV primers and 1 set of HPV16-specific primer. HPV+ OPSCC was defined as both >75% p16+ cells and PCR positive for HPV. Results. Of 26 Greenlandic patients diagnosed with OPSCC, 17 were males and 9 were females. The proportion of HPV+ OPSCC in the total study period was 22%, without significant changes in the population in Greenland. We found an increase in the proportion of HPV+ OPSCC from 14% in 1994–2001 to 25% in 2002–2010 (p=0.51). Among males from 20 to 27% (p=0.63) and in females from 0 to 20% (p=0.71). The annual OPSCC incidence increased from 2.3/100,000 (CI=1.2–4.2) in 1994–2001 to 3.8/100,000 (CI=2.4–6.2) in 2002–2010: among males from 2.4/100,000 (CI=1.0–5.7) to 5.0/100,000 (CI=2.9–8.9). Conclusion. Even though the population is at high risk of HPV infection, the proportion of 22% HPV+ OPSCC in the total study period is low compared to Europe and the United States. This might be explained by our small study size and/or by ethnic, geographical, sexual and cultural differences. Continuing observations of the OPSCC incidence and the proportion of HPV+ ... |
format |
Article in Journal/Newspaper |
author |
Magnus Balslev Avnstorp Ramon Gordon Jensen Emilie Garnæs Marianne Hamilton Therkildsen Bodil Norrild Lena Specht Christian von Buchwald Preben Homøe |
author_facet |
Magnus Balslev Avnstorp Ramon Gordon Jensen Emilie Garnæs Marianne Hamilton Therkildsen Bodil Norrild Lena Specht Christian von Buchwald Preben Homøe |
author_sort |
Magnus Balslev Avnstorp |
title |
Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010 |
title_short |
Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010 |
title_full |
Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010 |
title_fullStr |
Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010 |
title_full_unstemmed |
Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010 |
title_sort |
human papillomavirus and oropharyngeal cancer in greenland in 1994–2010 |
publisher |
Taylor & Francis Group |
publishDate |
2013 |
url |
https://doi.org/10.3402/ijch.v72i0.22386 https://doaj.org/article/32dbf4287efa4da895de27bcebf41477 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health inuit |
op_source |
International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-7 (2013) |
op_relation |
www.circumpolarhealthjournal.net/index.php/ijch/article/download/22386/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.22386 2242-3982 https://doaj.org/article/32dbf4287efa4da895de27bcebf41477 |
op_doi |
https://doi.org/10.3402/ijch.v72i0.22386 |
container_title |
International Journal of Circumpolar Health |
container_volume |
72 |
container_issue |
1 |
container_start_page |
22386 |
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1766348015260401664 |