The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study
ABSTRACTIn Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The var...
Published in: | International Journal of Circumpolar Health |
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Taylor & Francis Group
2023
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Online Access: | https://doi.org/10.1080/22423982.2023.2178067 https://doaj.org/article/32a54b5072174977b2084fe1d15aac67 |
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ftdoajarticles:oai:doaj.org/article:32a54b5072174977b2084fe1d15aac67 2024-01-21T10:04:02+01:00 The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study Ninna Karsbæk Senftleber Kristine Skøtt Pedersen Cecilie Schnoor Jørgensen Hanne Pedersen Marie Mathilde Bjerg Christensen Emilie Kabel Madsen Kristine Andersen Emil Jørsboe Matthew Paul Gillum Michael Bom Frøst Torben Hansen Marit Eika Jørgensen 2023-12-01T00:00:00Z https://doi.org/10.1080/22423982.2023.2178067 https://doaj.org/article/32a54b5072174977b2084fe1d15aac67 EN eng Taylor & Francis Group https://www.tandfonline.com/doi/10.1080/22423982.2023.2178067 https://doaj.org/toc/2242-3982 doi:10.1080/22423982.2023.2178067 2242-3982 https://doaj.org/article/32a54b5072174977b2084fe1d15aac67 International Journal of Circumpolar Health, Vol 82, Iss 1 (2023) Congenital sucrase-isomaltase deficiency inuit diet food preferences dietary intervention metabolism microbiota Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1080/22423982.2023.2178067 2023-12-24T01:42:47Z ABSTRACTIn Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656. Article in Journal/Newspaper Arctic Circumpolar Health Greenland greenlander* greenlandic International Journal of Circumpolar Health inuit Directory of Open Access Journals: DOAJ Articles Arctic Greenland International Journal of Circumpolar Health 82 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Congenital sucrase-isomaltase deficiency inuit diet food preferences dietary intervention metabolism microbiota Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Congenital sucrase-isomaltase deficiency inuit diet food preferences dietary intervention metabolism microbiota Arctic medicine. Tropical medicine RC955-962 Ninna Karsbæk Senftleber Kristine Skøtt Pedersen Cecilie Schnoor Jørgensen Hanne Pedersen Marie Mathilde Bjerg Christensen Emilie Kabel Madsen Kristine Andersen Emil Jørsboe Matthew Paul Gillum Michael Bom Frøst Torben Hansen Marit Eika Jørgensen The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
topic_facet |
Congenital sucrase-isomaltase deficiency inuit diet food preferences dietary intervention metabolism microbiota Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACTIn Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656. |
format |
Article in Journal/Newspaper |
author |
Ninna Karsbæk Senftleber Kristine Skøtt Pedersen Cecilie Schnoor Jørgensen Hanne Pedersen Marie Mathilde Bjerg Christensen Emilie Kabel Madsen Kristine Andersen Emil Jørsboe Matthew Paul Gillum Michael Bom Frøst Torben Hansen Marit Eika Jørgensen |
author_facet |
Ninna Karsbæk Senftleber Kristine Skøtt Pedersen Cecilie Schnoor Jørgensen Hanne Pedersen Marie Mathilde Bjerg Christensen Emilie Kabel Madsen Kristine Andersen Emil Jørsboe Matthew Paul Gillum Michael Bom Frøst Torben Hansen Marit Eika Jørgensen |
author_sort |
Ninna Karsbæk Senftleber |
title |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_short |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_full |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_fullStr |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_full_unstemmed |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_sort |
effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
publisher |
Taylor & Francis Group |
publishDate |
2023 |
url |
https://doi.org/10.1080/22423982.2023.2178067 https://doaj.org/article/32a54b5072174977b2084fe1d15aac67 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Circumpolar Health Greenland greenlander* greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Arctic Circumpolar Health Greenland greenlander* greenlandic International Journal of Circumpolar Health inuit |
op_source |
International Journal of Circumpolar Health, Vol 82, Iss 1 (2023) |
op_relation |
https://www.tandfonline.com/doi/10.1080/22423982.2023.2178067 https://doaj.org/toc/2242-3982 doi:10.1080/22423982.2023.2178067 2242-3982 https://doaj.org/article/32a54b5072174977b2084fe1d15aac67 |
op_doi |
https://doi.org/10.1080/22423982.2023.2178067 |
container_title |
International Journal of Circumpolar Health |
container_volume |
82 |
container_issue |
1 |
_version_ |
1788694453156839424 |