Harnessing case isolation and ring vaccination to control Ebola.
As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental natu...
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ftdoajarticles:oai:doaj.org/article:321a23f9ccc845838c1db743644166d3 2023-05-15T15:08:13+02:00 Harnessing case isolation and ring vaccination to control Ebola. Chad Wells Dan Yamin Martial L Ndeffo-Mbah Natasha Wenzel Stephen G Gaffney Jeffrey P Townsend Lauren Ancel Meyers Mosoka Fallah Tolbert G Nyenswah Frederick L Altice Katherine E Atkins Alison P Galvani 2015-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003794 https://doaj.org/article/321a23f9ccc845838c1db743644166d3 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4449200?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003794 https://doaj.org/article/321a23f9ccc845838c1db743644166d3 PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003794 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003794 2022-12-31T11:59:50Z As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine. To evaluate ring vaccination as a strategy for eliminating Ebola, we developed a pair approximation model of Ebola transmission, parameterized by confirmed incidence data from June 2014 to January 2015 in Liberia and Sierra Leone. Our results suggest that if a combined intervention of case isolation and ring vaccination had been initiated in the early fall of 2014, up to an additional 126 cases in Liberia and 560 cases in Sierra Leone could have been averted beyond case isolation alone. The marginal benefit of ring vaccination is predicted to be greatest in settings where there are more contacts per individual, greater clustering among individuals, when contact tracing has low efficacy or vaccination confers post-exposure protection. In such settings, ring vaccination can avert up to an additional 8% of Ebola cases. Accordingly, ring vaccination is predicted to offer a moderately beneficial supplement to ongoing non-pharmaceutical Ebola control efforts. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 5 e0003794 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Chad Wells Dan Yamin Martial L Ndeffo-Mbah Natasha Wenzel Stephen G Gaffney Jeffrey P Townsend Lauren Ancel Meyers Mosoka Fallah Tolbert G Nyenswah Frederick L Altice Katherine E Atkins Alison P Galvani Harnessing case isolation and ring vaccination to control Ebola. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine. To evaluate ring vaccination as a strategy for eliminating Ebola, we developed a pair approximation model of Ebola transmission, parameterized by confirmed incidence data from June 2014 to January 2015 in Liberia and Sierra Leone. Our results suggest that if a combined intervention of case isolation and ring vaccination had been initiated in the early fall of 2014, up to an additional 126 cases in Liberia and 560 cases in Sierra Leone could have been averted beyond case isolation alone. The marginal benefit of ring vaccination is predicted to be greatest in settings where there are more contacts per individual, greater clustering among individuals, when contact tracing has low efficacy or vaccination confers post-exposure protection. In such settings, ring vaccination can avert up to an additional 8% of Ebola cases. Accordingly, ring vaccination is predicted to offer a moderately beneficial supplement to ongoing non-pharmaceutical Ebola control efforts. |
format |
Article in Journal/Newspaper |
author |
Chad Wells Dan Yamin Martial L Ndeffo-Mbah Natasha Wenzel Stephen G Gaffney Jeffrey P Townsend Lauren Ancel Meyers Mosoka Fallah Tolbert G Nyenswah Frederick L Altice Katherine E Atkins Alison P Galvani |
author_facet |
Chad Wells Dan Yamin Martial L Ndeffo-Mbah Natasha Wenzel Stephen G Gaffney Jeffrey P Townsend Lauren Ancel Meyers Mosoka Fallah Tolbert G Nyenswah Frederick L Altice Katherine E Atkins Alison P Galvani |
author_sort |
Chad Wells |
title |
Harnessing case isolation and ring vaccination to control Ebola. |
title_short |
Harnessing case isolation and ring vaccination to control Ebola. |
title_full |
Harnessing case isolation and ring vaccination to control Ebola. |
title_fullStr |
Harnessing case isolation and ring vaccination to control Ebola. |
title_full_unstemmed |
Harnessing case isolation and ring vaccination to control Ebola. |
title_sort |
harnessing case isolation and ring vaccination to control ebola. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003794 https://doaj.org/article/321a23f9ccc845838c1db743644166d3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003794 (2015) |
op_relation |
http://europepmc.org/articles/PMC4449200?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003794 https://doaj.org/article/321a23f9ccc845838c1db743644166d3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003794 |
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PLOS Neglected Tropical Diseases |
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9 |
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5 |
container_start_page |
e0003794 |
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