Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study
Abstract High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strengt...
Published in: | Scientific Reports |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Portfolio
2021
|
Subjects: | |
Online Access: | https://doi.org/10.1038/s41598-021-01580-0 https://doaj.org/article/320363068d324bf1b1c979ccee8f634c |
id |
ftdoajarticles:oai:doaj.org/article:320363068d324bf1b1c979ccee8f634c |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:320363068d324bf1b1c979ccee8f634c 2023-05-15T15:08:46+02:00 Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study Simon Kornvig Maria Wielsøe Manhai Long Eva Cecilie Bonefeld-Jørgensen 2021-11-01T00:00:00Z https://doi.org/10.1038/s41598-021-01580-0 https://doaj.org/article/320363068d324bf1b1c979ccee8f634c EN eng Nature Portfolio https://doi.org/10.1038/s41598-021-01580-0 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-021-01580-0 2045-2322 https://doaj.org/article/320363068d324bf1b1c979ccee8f634c Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021) Medicine R Science Q article 2021 ftdoajarticles https://doi.org/10.1038/s41598-021-01580-0 2022-12-31T10:19:20Z Abstract High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3–5 years, parents answered an assisted questionnaire including children’s SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06, p = 0.010), β-hexachlorocyclohexane (β = 3.58, p = 0.004) and trans-nonachlor (β = 2.06, p = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3–5 year old children. Article in Journal/Newspaper Arctic greenlandic Directory of Open Access Journals: DOAJ Articles Arctic Scientific Reports 11 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Simon Kornvig Maria Wielsøe Manhai Long Eva Cecilie Bonefeld-Jørgensen Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study |
topic_facet |
Medicine R Science Q |
description |
Abstract High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3–5 years, parents answered an assisted questionnaire including children’s SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06, p = 0.010), β-hexachlorocyclohexane (β = 3.58, p = 0.004) and trans-nonachlor (β = 2.06, p = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3–5 year old children. |
format |
Article in Journal/Newspaper |
author |
Simon Kornvig Maria Wielsøe Manhai Long Eva Cecilie Bonefeld-Jørgensen |
author_facet |
Simon Kornvig Maria Wielsøe Manhai Long Eva Cecilie Bonefeld-Jørgensen |
author_sort |
Simon Kornvig |
title |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study |
title_short |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study |
title_full |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study |
title_fullStr |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study |
title_full_unstemmed |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study |
title_sort |
prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a greenlandic cohort study |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doi.org/10.1038/s41598-021-01580-0 https://doaj.org/article/320363068d324bf1b1c979ccee8f634c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic greenlandic |
genre_facet |
Arctic greenlandic |
op_source |
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021) |
op_relation |
https://doi.org/10.1038/s41598-021-01580-0 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-021-01580-0 2045-2322 https://doaj.org/article/320363068d324bf1b1c979ccee8f634c |
op_doi |
https://doi.org/10.1038/s41598-021-01580-0 |
container_title |
Scientific Reports |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766340073165422592 |