Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings
IntroductionThe first peak of COVID-19 in Brazil was between April and May 2020, at a time of the year when outbreaks of other tropical diseases, such as dengue, would be expected. COVID-19 and dengue have similar pathogenesis. In general, both may lead to mild symptoms but may also cause severe and...
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ftdoajarticles:oai:doaj.org/article:31fba5ecca1840c5b3dcb0e7e73eff58 2023-11-12T04:13:57+01:00 Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings Joyce Carnevale Rodrigues Débora Familiar-Macedo Thalia Medeiros Fabiana Rabe Carvalho Jorge Reis Almeida Andrea Alice Silva Flávia Barreto dos Santos Luiz José de Souza Paulo Vieira Damasco Elzinandes Leal Azeredo Luzia Maria de-Oliveira-Pinto 2023-10-01T00:00:00Z https://doi.org/10.3389/fitd.2023.1249574 https://doaj.org/article/31fba5ecca1840c5b3dcb0e7e73eff58 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fitd.2023.1249574/full https://doaj.org/toc/2673-7515 2673-7515 doi:10.3389/fitd.2023.1249574 https://doaj.org/article/31fba5ecca1840c5b3dcb0e7e73eff58 Frontiers in Tropical Diseases, Vol 4 (2023) COVID-19 dengue coinfection diagnosis human Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.3389/fitd.2023.1249574 2023-10-22T00:39:20Z IntroductionThe first peak of COVID-19 in Brazil was between April and May 2020, at a time of the year when outbreaks of other tropical diseases, such as dengue, would be expected. COVID-19 and dengue have similar pathogenesis. In general, both may lead to mild symptoms but may also cause severe and even fatal symptoms, especially in patients with comorbidities and probably in cases of overlapping infections. The general objective of this study was to assess whether, during the 2020 pandemic, there were cases of concomitant infection between SARS-CoV-2 and DENV.MethodsFor this, we evaluated the specificity and sensitivity of commercial serological anti-SARS-CoV-2 kits using plasma samples from patients with dengue and healthy donors recruited before COVID-19. In the case of confirmed cases of COVID-19/dengue, we evaluated the clinical evolution of these coinfected patients, compared with mono-infected patients; and quantified chemokines CCL2 and CXCL8 by ELISA in COVID-19 patients in order to correlate them with COVID-19/dengue severity and cases.Results and DiscussionOur results showed that commercial IgA and IgG anti-SARS-CoV-2 kits presented high sensitivity and specificity. This allowed us to see a low rate of co-detection or coinfection between SARS-CoV-2 and DENV in Rio de Janeiro. Among the 57 COVID-19 patients, anti-DENV IgM was detected in five (8.8%). COVID-19/dengue coinfected patients showed no clinical worsening of COVID-19 and cases in which COVID-19 patients had previous exposure to DENV did not influence the clinical severity of COVID-19. Lastly, CCL2 and CXCL8 appeared to be good markers of COVID-19 severity and did not show increased levels in COVID-19/dengue cases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Frontiers in Tropical Diseases 4 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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COVID-19 dengue coinfection diagnosis human Arctic medicine. Tropical medicine RC955-962 |
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COVID-19 dengue coinfection diagnosis human Arctic medicine. Tropical medicine RC955-962 Joyce Carnevale Rodrigues Débora Familiar-Macedo Thalia Medeiros Fabiana Rabe Carvalho Jorge Reis Almeida Andrea Alice Silva Flávia Barreto dos Santos Luiz José de Souza Paulo Vieira Damasco Elzinandes Leal Azeredo Luzia Maria de-Oliveira-Pinto Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings |
topic_facet |
COVID-19 dengue coinfection diagnosis human Arctic medicine. Tropical medicine RC955-962 |
description |
IntroductionThe first peak of COVID-19 in Brazil was between April and May 2020, at a time of the year when outbreaks of other tropical diseases, such as dengue, would be expected. COVID-19 and dengue have similar pathogenesis. In general, both may lead to mild symptoms but may also cause severe and even fatal symptoms, especially in patients with comorbidities and probably in cases of overlapping infections. The general objective of this study was to assess whether, during the 2020 pandemic, there were cases of concomitant infection between SARS-CoV-2 and DENV.MethodsFor this, we evaluated the specificity and sensitivity of commercial serological anti-SARS-CoV-2 kits using plasma samples from patients with dengue and healthy donors recruited before COVID-19. In the case of confirmed cases of COVID-19/dengue, we evaluated the clinical evolution of these coinfected patients, compared with mono-infected patients; and quantified chemokines CCL2 and CXCL8 by ELISA in COVID-19 patients in order to correlate them with COVID-19/dengue severity and cases.Results and DiscussionOur results showed that commercial IgA and IgG anti-SARS-CoV-2 kits presented high sensitivity and specificity. This allowed us to see a low rate of co-detection or coinfection between SARS-CoV-2 and DENV in Rio de Janeiro. Among the 57 COVID-19 patients, anti-DENV IgM was detected in five (8.8%). COVID-19/dengue coinfected patients showed no clinical worsening of COVID-19 and cases in which COVID-19 patients had previous exposure to DENV did not influence the clinical severity of COVID-19. Lastly, CCL2 and CXCL8 appeared to be good markers of COVID-19 severity and did not show increased levels in COVID-19/dengue cases. |
format |
Article in Journal/Newspaper |
author |
Joyce Carnevale Rodrigues Débora Familiar-Macedo Thalia Medeiros Fabiana Rabe Carvalho Jorge Reis Almeida Andrea Alice Silva Flávia Barreto dos Santos Luiz José de Souza Paulo Vieira Damasco Elzinandes Leal Azeredo Luzia Maria de-Oliveira-Pinto |
author_facet |
Joyce Carnevale Rodrigues Débora Familiar-Macedo Thalia Medeiros Fabiana Rabe Carvalho Jorge Reis Almeida Andrea Alice Silva Flávia Barreto dos Santos Luiz José de Souza Paulo Vieira Damasco Elzinandes Leal Azeredo Luzia Maria de-Oliveira-Pinto |
author_sort |
Joyce Carnevale Rodrigues |
title |
Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings |
title_short |
Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings |
title_full |
Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings |
title_fullStr |
Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings |
title_full_unstemmed |
Assessment of threat of concurrent SARS-CoV-2 and DENV infection in the COVID-19 pandemic in Brazil in 2020: diagnostic and immunological findings |
title_sort |
assessment of threat of concurrent sars-cov-2 and denv infection in the covid-19 pandemic in brazil in 2020: diagnostic and immunological findings |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
https://doi.org/10.3389/fitd.2023.1249574 https://doaj.org/article/31fba5ecca1840c5b3dcb0e7e73eff58 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Frontiers in Tropical Diseases, Vol 4 (2023) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fitd.2023.1249574/full https://doaj.org/toc/2673-7515 2673-7515 doi:10.3389/fitd.2023.1249574 https://doaj.org/article/31fba5ecca1840c5b3dcb0e7e73eff58 |
op_doi |
https://doi.org/10.3389/fitd.2023.1249574 |
container_title |
Frontiers in Tropical Diseases |
container_volume |
4 |
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1782331725596065792 |