High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon ( Salmo salar ) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat ( Sprattus sprattus ) and herring (Clupea harengus) . The concentration of n − 3 p...
Published in: | Biomolecules |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2022
|
Subjects: | |
Online Access: | https://doi.org/10.3390/biom12040526 https://doaj.org/article/319a471ff91f402caa78c6d857741942 |
id |
ftdoajarticles:oai:doaj.org/article:319a471ff91f402caa78c6d857741942 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:319a471ff91f402caa78c6d857741942 2023-05-15T15:30:51+02:00 High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen 2022-03-01T00:00:00Z https://doi.org/10.3390/biom12040526 https://doaj.org/article/319a471ff91f402caa78c6d857741942 EN eng MDPI AG https://www.mdpi.com/2218-273X/12/4/526 https://doaj.org/toc/2218-273X doi:10.3390/biom12040526 2218-273X https://doaj.org/article/319a471ff91f402caa78c6d857741942 Biomolecules, Vol 12, Iss 526, p 526 (2022) Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde Microbiology QR1-502 article 2022 ftdoajarticles https://doi.org/10.3390/biom12040526 2022-12-30T23:34:47Z Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon ( Salmo salar ) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat ( Sprattus sprattus ) and herring (Clupea harengus) . The concentration of n − 3 polyunsaturated fatty acids ( n − 3 PUFAs) increased in salmon with dietary lipids and n − 3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n − 3 PUFA and docosahexaenoic acid (DHA, 22:6 n − 3 ) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with the increase in both body lipid and n − 3 PUFA or DHA concentration. The hepatic glucose 6-phosphate dehydrogenase activity was suppressed by high dietary lipids. In salmon muscle and in prey fish, the proportion of thiamine pyrophosphate increased, and that of free thiamine decreased, with increasing body lipid content or PUFAs, or merely DHA. The thiamine status of salmon was impaired mainly due to the peroxidation of n − 3 PUFAs, whereas lipids as a source of metabolic energy had less effect. Organochlorines or general oxidative stress did not affect the thiamine status. The amount of lipids, and, specifically, their long-chain n − 3 PUFAs, are thus responsible for generating thiamine deficiency, and not a prey fish species per se. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles Biomolecules 12 4 526 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde Microbiology QR1-502 |
spellingShingle |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde Microbiology QR1-502 Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices |
topic_facet |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde Microbiology QR1-502 |
description |
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon ( Salmo salar ) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat ( Sprattus sprattus ) and herring (Clupea harengus) . The concentration of n − 3 polyunsaturated fatty acids ( n − 3 PUFAs) increased in salmon with dietary lipids and n − 3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n − 3 PUFA and docosahexaenoic acid (DHA, 22:6 n − 3 ) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with the increase in both body lipid and n − 3 PUFA or DHA concentration. The hepatic glucose 6-phosphate dehydrogenase activity was suppressed by high dietary lipids. In salmon muscle and in prey fish, the proportion of thiamine pyrophosphate increased, and that of free thiamine decreased, with increasing body lipid content or PUFAs, or merely DHA. The thiamine status of salmon was impaired mainly due to the peroxidation of n − 3 PUFAs, whereas lipids as a source of metabolic energy had less effect. Organochlorines or general oxidative stress did not affect the thiamine status. The amount of lipids, and, specifically, their long-chain n − 3 PUFAs, are thus responsible for generating thiamine deficiency, and not a prey fish species per se. |
format |
Article in Journal/Newspaper |
author |
Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen |
author_facet |
Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen |
author_sort |
Marja Keinänen |
title |
High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices |
title_short |
High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices |
title_full |
High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices |
title_fullStr |
High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices |
title_full_unstemmed |
High Lipid Content of Prey Fish and n − 3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon ( Salmo salar ) and Is Reflected in Hepatic Biochemical Indices |
title_sort |
high lipid content of prey fish and n − 3 pufa peroxidation impair the thiamine status of feeding-migrating atlantic salmon ( salmo salar ) and is reflected in hepatic biochemical indices |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/biom12040526 https://doaj.org/article/319a471ff91f402caa78c6d857741942 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Biomolecules, Vol 12, Iss 526, p 526 (2022) |
op_relation |
https://www.mdpi.com/2218-273X/12/4/526 https://doaj.org/toc/2218-273X doi:10.3390/biom12040526 2218-273X https://doaj.org/article/319a471ff91f402caa78c6d857741942 |
op_doi |
https://doi.org/10.3390/biom12040526 |
container_title |
Biomolecules |
container_volume |
12 |
container_issue |
4 |
container_start_page |
526 |
_version_ |
1766361324609077248 |