Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance
Objective: To evaluate the effect of myricetin on ovalbumin (OVA)-induced allergic rhinitis in mice. Methods: Mice were sensitized and challenged using OVA (5%, 500 mL) intraperitoneally and intranasally, respectively, on an alternative day for 14 days, followed by administration of myricetin (50, 1...
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Wolters Kluwer Medknow Publications
2023
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Online Access: | https://doi.org/10.4103/2221-1691.380562 https://doaj.org/article/31777027a68749c0aec76d0c261603ba |
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ftdoajarticles:oai:doaj.org/article:31777027a68749c0aec76d0c261603ba 2023-11-12T04:13:19+01:00 Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance Ya-Nan Shi Jin-Zhu Su Juan Wang Jiang-Qiao Geng 2023-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.380562 https://doaj.org/article/31777027a68749c0aec76d0c261603ba EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=7;spage=306;epage=314;aulast=Shi https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.380562 https://doaj.org/article/31777027a68749c0aec76d0c261603ba Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 7, Pp 306-314 (2023) allergic rhinitis gata3 interleukins myricetin montelukast ovalbumin th1/th2 balance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2023 ftdoajarticles https://doi.org/10.4103/2221-1691.380562 2023-10-29T00:38:43Z Objective: To evaluate the effect of myricetin on ovalbumin (OVA)-induced allergic rhinitis in mice. Methods: Mice were sensitized and challenged using OVA (5%, 500 mL) intraperitoneally and intranasally, respectively, on an alternative day for 14 days, followed by administration of myricetin (50, 100, and 200 mg/kg) till day 21. Nasal symptoms, biochemical parameters, protein expressions, and histopathology were observed. Results: OVA-induced increased nasal symptoms including rubbing, sneezing, and discharge were significantly reduced by myricetin (100 and 200 mg/kg) (P<0.05). Myricetin also protected against histamine challenge and attenuated elevated serum immunoglobulin E (IgE; total and OVA-specific), total IgG1, and β-hexosaminidase levels, as well as leukotriene C4 and interleukins levels in nasal lavage fluid (P<0.05). Western blot analysis showed that myricetin significantly upregulated the protein expression of T-box expressed in T cells, while downregulating the protein expression of GATA binding protein 3, NF-κB, and 1κВ-α (P<0.05). Additionally, OVA-induced histopathological abberations in the nasal mucosa was markedly ameliorated by myricetin treatment (P<0.05). Conclusions: Myricetin exerts anti-allergic effects against OVA-induced allergic rhinitis via regulating Th1/Th2 balance. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Gata ENVELOPE(-19.702,-19.702,63.540,63.540) Asian Pacific Journal of Tropical Biomedicine 13 7 306 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
allergic rhinitis gata3 interleukins myricetin montelukast ovalbumin th1/th2 balance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
allergic rhinitis gata3 interleukins myricetin montelukast ovalbumin th1/th2 balance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Ya-Nan Shi Jin-Zhu Su Juan Wang Jiang-Qiao Geng Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance |
topic_facet |
allergic rhinitis gata3 interleukins myricetin montelukast ovalbumin th1/th2 balance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the effect of myricetin on ovalbumin (OVA)-induced allergic rhinitis in mice. Methods: Mice were sensitized and challenged using OVA (5%, 500 mL) intraperitoneally and intranasally, respectively, on an alternative day for 14 days, followed by administration of myricetin (50, 100, and 200 mg/kg) till day 21. Nasal symptoms, biochemical parameters, protein expressions, and histopathology were observed. Results: OVA-induced increased nasal symptoms including rubbing, sneezing, and discharge were significantly reduced by myricetin (100 and 200 mg/kg) (P<0.05). Myricetin also protected against histamine challenge and attenuated elevated serum immunoglobulin E (IgE; total and OVA-specific), total IgG1, and β-hexosaminidase levels, as well as leukotriene C4 and interleukins levels in nasal lavage fluid (P<0.05). Western blot analysis showed that myricetin significantly upregulated the protein expression of T-box expressed in T cells, while downregulating the protein expression of GATA binding protein 3, NF-κB, and 1κВ-α (P<0.05). Additionally, OVA-induced histopathological abberations in the nasal mucosa was markedly ameliorated by myricetin treatment (P<0.05). Conclusions: Myricetin exerts anti-allergic effects against OVA-induced allergic rhinitis via regulating Th1/Th2 balance. |
format |
Article in Journal/Newspaper |
author |
Ya-Nan Shi Jin-Zhu Su Juan Wang Jiang-Qiao Geng |
author_facet |
Ya-Nan Shi Jin-Zhu Su Juan Wang Jiang-Qiao Geng |
author_sort |
Ya-Nan Shi |
title |
Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance |
title_short |
Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance |
title_full |
Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance |
title_fullStr |
Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance |
title_full_unstemmed |
Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance |
title_sort |
myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating th1/th2 balance |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/2221-1691.380562 https://doaj.org/article/31777027a68749c0aec76d0c261603ba |
long_lat |
ENVELOPE(-19.702,-19.702,63.540,63.540) |
geographic |
Arctic Gata |
geographic_facet |
Arctic Gata |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 7, Pp 306-314 (2023) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=7;spage=306;epage=314;aulast=Shi https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.380562 https://doaj.org/article/31777027a68749c0aec76d0c261603ba |
op_doi |
https://doi.org/10.4103/2221-1691.380562 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
13 |
container_issue |
7 |
container_start_page |
306 |
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1782331378458689536 |