Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients...
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ftdoajarticles:oai:doaj.org/article:312c17243af040878fa0dadf5f191797 2023-05-15T15:15:39+02:00 Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. Kantasit Wisanuvej Kochawan Boonyawat Chutchaiwat Savetamornkul Sirapong Virapongsiri Jatupon Krongvorakul Somnuek Sungkanuparph Angsana Phuphuakrat 2021-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009692 https://doaj.org/article/312c17243af040878fa0dadf5f191797 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009692 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009692 https://doaj.org/article/312c17243af040878fa0dadf5f191797 PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009692 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009692 2022-12-31T15:17:37Z Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients. Methodology and principal findings Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb ≥20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively. Conclusions Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 8 e0009692 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kantasit Wisanuvej Kochawan Boonyawat Chutchaiwat Savetamornkul Sirapong Virapongsiri Jatupon Krongvorakul Somnuek Sungkanuparph Angsana Phuphuakrat Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients. Methodology and principal findings Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb ≥20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively. Conclusions Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb ... |
format |
Article in Journal/Newspaper |
author |
Kantasit Wisanuvej Kochawan Boonyawat Chutchaiwat Savetamornkul Sirapong Virapongsiri Jatupon Krongvorakul Somnuek Sungkanuparph Angsana Phuphuakrat |
author_facet |
Kantasit Wisanuvej Kochawan Boonyawat Chutchaiwat Savetamornkul Sirapong Virapongsiri Jatupon Krongvorakul Somnuek Sungkanuparph Angsana Phuphuakrat |
author_sort |
Kantasit Wisanuvej |
title |
Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. |
title_short |
Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. |
title_full |
Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. |
title_fullStr |
Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. |
title_full_unstemmed |
Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. |
title_sort |
comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009692 https://doaj.org/article/312c17243af040878fa0dadf5f191797 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009692 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009692 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009692 https://doaj.org/article/312c17243af040878fa0dadf5f191797 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009692 |
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PLOS Neglected Tropical Diseases |
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15 |
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8 |
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e0009692 |
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1766346012730851328 |