Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study
Objective: To compare the genotype frequencies of HLA class- II DRB1 alleles in Giardia (G.) lamblia-infected children. Methods: A total of 490 Egyptian children aged 2-16 years were subjected to microscopic stool examination to detect G. lamblia infection, and to exclude other intestinal pathogens....
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ftdoajarticles:oai:doaj.org/article:31181ab8873348b0914271e5ad9d7080 2023-05-15T15:08:38+02:00 Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study Samar N El-Beshbishi Ayat A ElBlihy Raefa A Atia Ahmed Megahed Fatma A Auf 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.275413 https://doaj.org/article/31181ab8873348b0914271e5ad9d7080 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=2;spage=56;epage=61;aulast=El-Beshbishi https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.275413 https://doaj.org/article/31181ab8873348b0914271e5ad9d7080 Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 2, Pp 56-61 (2020) giardia lamblia giardiasis human leukocyte antigen hla class- ii drb1 alleles children Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.275413 2022-12-31T00:07:15Z Objective: To compare the genotype frequencies of HLA class- II DRB1 alleles in Giardia (G.) lamblia-infected children. Methods: A total of 490 Egyptian children aged 2-16 years were subjected to microscopic stool examination to detect G. lamblia infection, and to exclude other intestinal pathogens. On the basis of their microscopic findings, a group of 80 children were chosen as giardiasis cases, another 80 children were confirmed as Giardia free control group by immunochromatographic test, and the remaining children were excluded. Both giardiasis and control groups were then subjected to blood examination to identify their genetic type of HLA-DRB1 alleles. Results: HLA class-II DRB1*03:01 and DRB1*13:01 alleles were significantly associated with G. lamblia infection (P<0.001 for each variable). On the other hand, HLA class-II DRB1*04:02, DRB1*10:01, DRB1*14:01 and DRB1*15:01 alleles were significantly demonstrated in Giardia free children. However, other HLA-DRB1 alleles did not show any significant association with giardiasis. Conclusions: HLA class-II DRB1*03, DRB1*13, DRB1*04, DRB1*10, DRB1*14 and DRB1*15 alleles may be involved in the establishment of host immune response to G. lamblia infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 13 2 56 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
giardia lamblia giardiasis human leukocyte antigen hla class- ii drb1 alleles children Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
giardia lamblia giardiasis human leukocyte antigen hla class- ii drb1 alleles children Arctic medicine. Tropical medicine RC955-962 Samar N El-Beshbishi Ayat A ElBlihy Raefa A Atia Ahmed Megahed Fatma A Auf Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study |
topic_facet |
giardia lamblia giardiasis human leukocyte antigen hla class- ii drb1 alleles children Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To compare the genotype frequencies of HLA class- II DRB1 alleles in Giardia (G.) lamblia-infected children. Methods: A total of 490 Egyptian children aged 2-16 years were subjected to microscopic stool examination to detect G. lamblia infection, and to exclude other intestinal pathogens. On the basis of their microscopic findings, a group of 80 children were chosen as giardiasis cases, another 80 children were confirmed as Giardia free control group by immunochromatographic test, and the remaining children were excluded. Both giardiasis and control groups were then subjected to blood examination to identify their genetic type of HLA-DRB1 alleles. Results: HLA class-II DRB1*03:01 and DRB1*13:01 alleles were significantly associated with G. lamblia infection (P<0.001 for each variable). On the other hand, HLA class-II DRB1*04:02, DRB1*10:01, DRB1*14:01 and DRB1*15:01 alleles were significantly demonstrated in Giardia free children. However, other HLA-DRB1 alleles did not show any significant association with giardiasis. Conclusions: HLA class-II DRB1*03, DRB1*13, DRB1*04, DRB1*10, DRB1*14 and DRB1*15 alleles may be involved in the establishment of host immune response to G. lamblia infection. |
format |
Article in Journal/Newspaper |
author |
Samar N El-Beshbishi Ayat A ElBlihy Raefa A Atia Ahmed Megahed Fatma A Auf |
author_facet |
Samar N El-Beshbishi Ayat A ElBlihy Raefa A Atia Ahmed Megahed Fatma A Auf |
author_sort |
Samar N El-Beshbishi |
title |
Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study |
title_short |
Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study |
title_full |
Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study |
title_fullStr |
Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study |
title_full_unstemmed |
Human leukocyte antigen class-II DRB1 alleles and Giardia lamblia infection in children: A case-control study |
title_sort |
human leukocyte antigen class-ii drb1 alleles and giardia lamblia infection in children: a case-control study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.275413 https://doaj.org/article/31181ab8873348b0914271e5ad9d7080 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 2, Pp 56-61 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=2;spage=56;epage=61;aulast=El-Beshbishi https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.275413 https://doaj.org/article/31181ab8873348b0914271e5ad9d7080 |
op_doi |
https://doi.org/10.4103/1995-7645.275413 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
2 |
container_start_page |
56 |
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1766339957124759552 |