Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs.
The relationship between mosquito vectors and lymphatic filariasis (LF) parasites can result in a range of transmission outcomes. Anophelines are generally characterized as poor vectors due to an inability to support development at low densities. However, it is important to understand the potential...
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ftdoajarticles:oai:doaj.org/article:30df1b4f10a14892a5aa93a96c2d044a 2023-05-15T15:12:58+02:00 Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. Sara M Erickson Edward K Thomsen John B Keven Naomi Vincent Gussy Koimbu Peter M Siba Bruce M Christensen Lisa J Reimer 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002433 https://doaj.org/article/30df1b4f10a14892a5aa93a96c2d044a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3772046?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002433 https://doaj.org/article/30df1b4f10a14892a5aa93a96c2d044a PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2433 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002433 2022-12-31T00:08:13Z The relationship between mosquito vectors and lymphatic filariasis (LF) parasites can result in a range of transmission outcomes. Anophelines are generally characterized as poor vectors due to an inability to support development at low densities. However, it is important to understand the potential for transmission in natural vectors to maximize the success of elimination efforts. Primary vectors in Papua New Guinea (n = 1209) were dissected following exposure to microfilaremic blood (range 8-233 mf/20 µl). We examined density dependent and species-specific parasite prevalence, intensity and yield, barriers to parasite development as well as impacts on mosquito survival. We observed strikingly different parasite prevalence and yield among closely related species. Prevalence of infective stage larvae (L3s) ranged from 4.2% to 23.7% in An. punctulatus, 24.5% to 68.6% in An. farauti s.s. and 61.9% to 100% in An. hinesorum at low and high density exposures, respectively. Injection experiments revealed the greatest barrier to parasite development involved passage from the midgut into the hemocoel. The ratio of L3 to ingested mf at low densities was higher in An. hinesorum (yield = 1.0) and An. farauti s.s. (yield = 0.5) than has been reported in other anopheline vectors. There was a negative relationship between mosquito survival and bloodmeal mf density. In An. farauti s.s., increased parasite yield and survival at low densities suggest greater competence at low microfilaremias. In Papua New Guinea the likelihood of transmission will be strongly influenced by vector composition and changes in the mf reservoir as a result of elimination efforts. Global elimination efforts will be strengthened by the knowledge of transmission potential in the context of current control measures. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 9 e2433 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sara M Erickson Edward K Thomsen John B Keven Naomi Vincent Gussy Koimbu Peter M Siba Bruce M Christensen Lisa J Reimer Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The relationship between mosquito vectors and lymphatic filariasis (LF) parasites can result in a range of transmission outcomes. Anophelines are generally characterized as poor vectors due to an inability to support development at low densities. However, it is important to understand the potential for transmission in natural vectors to maximize the success of elimination efforts. Primary vectors in Papua New Guinea (n = 1209) were dissected following exposure to microfilaremic blood (range 8-233 mf/20 µl). We examined density dependent and species-specific parasite prevalence, intensity and yield, barriers to parasite development as well as impacts on mosquito survival. We observed strikingly different parasite prevalence and yield among closely related species. Prevalence of infective stage larvae (L3s) ranged from 4.2% to 23.7% in An. punctulatus, 24.5% to 68.6% in An. farauti s.s. and 61.9% to 100% in An. hinesorum at low and high density exposures, respectively. Injection experiments revealed the greatest barrier to parasite development involved passage from the midgut into the hemocoel. The ratio of L3 to ingested mf at low densities was higher in An. hinesorum (yield = 1.0) and An. farauti s.s. (yield = 0.5) than has been reported in other anopheline vectors. There was a negative relationship between mosquito survival and bloodmeal mf density. In An. farauti s.s., increased parasite yield and survival at low densities suggest greater competence at low microfilaremias. In Papua New Guinea the likelihood of transmission will be strongly influenced by vector composition and changes in the mf reservoir as a result of elimination efforts. Global elimination efforts will be strengthened by the knowledge of transmission potential in the context of current control measures. |
format |
Article in Journal/Newspaper |
author |
Sara M Erickson Edward K Thomsen John B Keven Naomi Vincent Gussy Koimbu Peter M Siba Bruce M Christensen Lisa J Reimer |
author_facet |
Sara M Erickson Edward K Thomsen John B Keven Naomi Vincent Gussy Koimbu Peter M Siba Bruce M Christensen Lisa J Reimer |
author_sort |
Sara M Erickson |
title |
Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. |
title_short |
Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. |
title_full |
Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. |
title_fullStr |
Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. |
title_full_unstemmed |
Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. |
title_sort |
mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002433 https://doaj.org/article/30df1b4f10a14892a5aa93a96c2d044a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2433 (2013) |
op_relation |
http://europepmc.org/articles/PMC3772046?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002433 https://doaj.org/article/30df1b4f10a14892a5aa93a96c2d044a |
op_doi |
https://doi.org/10.1371/journal.pntd.0002433 |
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PLoS Neglected Tropical Diseases |
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7 |
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9 |
container_start_page |
e2433 |
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