Antiprotozoal action of synthetic cinnamic acid analogs

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Ana Paula de Azevedo dos Santos, Saara Nery Fialho, Daniel Sol Sol de Medeiros, Ana Fidelina Gómez Garay, Jorge Alfonso Ruiz Diaz, Maria Celeste Vega Gómez, Carolina Bioni Garcia Teles, Leonardo de Azevedo Calderon
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Bioactivity; Cinnamic acid; Leishmaniasis; Synthetic; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0499-2017; https://doaj.org/article/30aafd7459ad4cfb8286e1da09bdd4a1

Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. RESULTS Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. CONCLUSIONS Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.