Global fingerprint of humans on the distribution of Bartonella bacteria in mammals.
As humans move and alter habitats, they change the disease risk for themselves, their commensal animals and wildlife. Bartonella bacteria are prevalent in mammals and cause numerous human infections. Understanding how this genus has evolved and switched hosts in the past can reveal how current patte...
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ftdoajarticles:oai:doaj.org/article:307d2ffebd1646919ec0964e0274a61a 2023-05-15T15:04:18+02:00 Global fingerprint of humans on the distribution of Bartonella bacteria in mammals. Hannah K Frank Scott D Boyd Elizabeth A Hadly 2018-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006865 https://doaj.org/article/307d2ffebd1646919ec0964e0274a61a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6237287?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006865 https://doaj.org/article/307d2ffebd1646919ec0964e0274a61a PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006865 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006865 2022-12-31T14:52:30Z As humans move and alter habitats, they change the disease risk for themselves, their commensal animals and wildlife. Bartonella bacteria are prevalent in mammals and cause numerous human infections. Understanding how this genus has evolved and switched hosts in the past can reveal how current patterns were established and identify potential mechanisms for future cross-species transmission. We analyzed patterns of Bartonella transmission and likely sources of spillover using the largest collection of Bartonella gltA genotypes assembled, including 67 new genotypes. This pathogenic genus likely originated as an environmental bacterium and insect commensal before infecting mammals. Rodents and domestic animals serve as the reservoirs or at least key proximate host for most Bartonella genotypes in humans. We also find evidence of exchange of Bartonella between phylogenetically distant domestic animals and wildlife, likely due to increased contact. Care should be taken to avoid contact between humans, domestic animals and wildlife to protect the health of all. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 11 e0006865 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hannah K Frank Scott D Boyd Elizabeth A Hadly Global fingerprint of humans on the distribution of Bartonella bacteria in mammals. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
As humans move and alter habitats, they change the disease risk for themselves, their commensal animals and wildlife. Bartonella bacteria are prevalent in mammals and cause numerous human infections. Understanding how this genus has evolved and switched hosts in the past can reveal how current patterns were established and identify potential mechanisms for future cross-species transmission. We analyzed patterns of Bartonella transmission and likely sources of spillover using the largest collection of Bartonella gltA genotypes assembled, including 67 new genotypes. This pathogenic genus likely originated as an environmental bacterium and insect commensal before infecting mammals. Rodents and domestic animals serve as the reservoirs or at least key proximate host for most Bartonella genotypes in humans. We also find evidence of exchange of Bartonella between phylogenetically distant domestic animals and wildlife, likely due to increased contact. Care should be taken to avoid contact between humans, domestic animals and wildlife to protect the health of all. |
format |
Article in Journal/Newspaper |
author |
Hannah K Frank Scott D Boyd Elizabeth A Hadly |
author_facet |
Hannah K Frank Scott D Boyd Elizabeth A Hadly |
author_sort |
Hannah K Frank |
title |
Global fingerprint of humans on the distribution of Bartonella bacteria in mammals. |
title_short |
Global fingerprint of humans on the distribution of Bartonella bacteria in mammals. |
title_full |
Global fingerprint of humans on the distribution of Bartonella bacteria in mammals. |
title_fullStr |
Global fingerprint of humans on the distribution of Bartonella bacteria in mammals. |
title_full_unstemmed |
Global fingerprint of humans on the distribution of Bartonella bacteria in mammals. |
title_sort |
global fingerprint of humans on the distribution of bartonella bacteria in mammals. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006865 https://doaj.org/article/307d2ffebd1646919ec0964e0274a61a |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006865 (2018) |
op_relation |
http://europepmc.org/articles/PMC6237287?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006865 https://doaj.org/article/307d2ffebd1646919ec0964e0274a61a |
op_doi |
https://doi.org/10.1371/journal.pntd.0006865 |
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PLOS Neglected Tropical Diseases |
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12 |
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11 |
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e0006865 |
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1766336092064186368 |